Immunosenescence and the 3Rs: Restoration, Replacement and Reprogramming

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-3-0346-0219-8_9
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• References Subscriptions Permissions Email Alerts Immune Enhancing Effect of a Growth Hormone Secretagogue

  2013cited by this paper
• Zinc and ageing.

  2011cited by this paper
• Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

  2010cited by this paper
• Epigenetic Reprogramming by Somatic Cell Nuclear Transfer in Primates

  2009cited by this paper
• Inhibitions of vascular endothelial growth factor expression and foam cell formation by EGb 761, a special extract of Ginkgo biloba, in oxidatively modified low-density lipoprotein-induced human THP-1 monocytes cells.

  2009cited by this paper
• The prevention and treatment of cytomegalovirus infection in haematopoietic stem cell transplantation

  2009cited by this paper
• The immune system and the impact of zinc during aging

  2009cited by this paper
• Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells.

  2009influential reference
• Balancing out the ends during iPSC nuclear reprogramming.

  2009cited by this paper
• Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade

  2008cited by this paper
• Immunity, ageing and cancer

  2008cited by this paper
• The effect of bilirubin on the fc receptor expression and phagocytic activity of mouse peritoneal macrophages

  2008cited by this paper
• Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

  2008cited by this paper
• Guidelines and techniques for the generation of induced pluripotent stem cells.

  2008cited by this paper
• Strategies and new developments in the generation of patient-specific pluripotent stem cells.

  2007cited by this paper
• Altered Innate Immune Functioning of Dendritic Cells in Elderly Humans: A Role of Phosphoinositide 3-Kinase-Signaling Pathway1

  2007cited by this paper
• Expression of nerve growth factor is upregulated in the rat thymic epithelial cells during thymus regeneration following acute thymic involution.

  2007cited by this paper
• Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

  2007cited by this paper
• T-cell potential and development in vitro: the OP9-DL1 approach.

  2007cited by this paper
• Enhanced Immune Reconstitution by Sex Steroid Ablation following Allogeneic Hemopoietic Stem Cell Transplantation1

  2007cited by this paper
• The molecular basis of ageing in stem cells.

  2007cited by this paper
• Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: the ZENITH Study.

  2007cited by this paper
• Growth hormone supplementation in the elderly.

  2007cited by this paper
• In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

  2007cited by this paper
• Producing primate embryonic stem cells by somatic cell nuclear transfer

  2007cited by this paper
• Old Rhesus Macaques Treated with Interleukin-7 Show Increased TREC Levels And Respond Well to Influenza Vaccination

  2007cited by this paper
• Telomere lengthening early in development

  2007cited by this paper
• Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

  2007cited by this paper
• T cell therapies following hematopoietic stem cell transplantation: surely there must be a better way than DLI?

  2007cited by this paper
• Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts

  2007cited by this paper
• Up-regulation of VEGF expression by NGF that enhances reparative angiogenesis during thymic regeneration in adult rat.

  2007cited by this paper
• Zinc-binding proteins (metallothionein and alpha-2 macroglobulin) and immunosenescence.

  2006cited by this paper
• Cutting Edge: Three-Dimensional Architecture of the Thymus Is Required to Maintain Delta-Like Expression Necessary for Inducing T Cell Development1

  2006cited by this paper
• IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells

  2006cited by this paper
• Nuclear reprogramming and pluripotency

  2006cited by this paper
• Zinc and ageing (ZINCAGE Project)

  2006cited by this paper
• Reassessing the role of growth hormone and sex steroids in thymic involution.

  2006cited by this paper
• IL-7 in allogeneic transplant: Clinical promise and potential pitfalls

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• A Novel Approach to Thymic Rejuvenation in the Aged

  2006cited by this paper
• Insights into thymic aging and regeneration

  2005cited by this paper
• Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool.

  2005cited by this paper
• An IL-7 Fusion Protein That Shows Increased Thymopoietic Ability1

  2005cited by this paper
• Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers

  2005cited by this paper
• Human skin cells support thymus-independent T cell development.

  2005cited by this paper
• Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells

  2005cited by this paper
• Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade

  2005cited by this paper
• Development of growth hormone secretagogues.

  2005cited by this paper
• Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior

  2005cited by this paper
• Effects of Castration on Thymocyte Development in Two Different Models of Thymic Involution1

  2005cited by this paper
• Effects of aging on early B‐ and T‐cell development

  2005cited by this paper
• T-cell reconstitution and expansion after hematopoietic stem cell transplantation: ‘T’ it up!

  2005cited by this paper
• Developments in ghrelin biology and potential clinical relevance.

  2005cited by this paper
• Memory T-cell homeostasis and senescence during aging.

  2005cited by this paper
• Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro.

  2005cited by this paper
• Intrinsic versus environmental influences on T‐cell responses in aging

  2005cited by this paper
• An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.

  2005cited by this paper
• Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants.

  2004cited by this paper
• NK and NKT cell functions in immunosenescence

  2004cited by this paper
• Genetic Manipulation of Telomerase in HIV-Specific CD8+ T Cells: Enhanced Antiviral Functions Accompany the Increased Proliferative Potential and Telomere Length Stabilization1

  2004cited by this paper
• Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection1

  2004cited by this paper
• Innate immunity in aging: impact on macrophage function

  2004cited by this paper
• IL-7 Gene Therapy in Aging Restores Early Thymopoiesis without Reversing Involution

  2004cited by this paper
• Human Telomerase Reverse Transcriptase-Transduced Human Cytotoxic T Cells Suppress the Growth of Human Melanoma in Immunodeficient Mice

  2004cited by this paper
• The Effects of MK‐0677, an Oral Growth Hormone Secretagogue, in Patients with Hip Fracture

  2004cited by this paper
• Aging and innate immune cells

  2004cited by this paper
• Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro

  2004cited by this paper
• Reprogramming of the immune system during zinc deficiency.

  2004cited by this paper
• Aging, immunity and cancer.

  2004cited by this paper
• Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells

  2003cited by this paper
• Effects of Ginkgo biloba extract (EGb 761) on hydroxyl radical-induced thymocyte apoptosis and on age-related thymic atrophy and peripheral immune dysfunctions in mice.

  2003cited by this paper
• IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation.

  2003cited by this paper
• Dyskeratosis congenita: its link to telomerase and aplastic anaemia.

  2003cited by this paper
• Differential Requirement for Mesenchyme in the Proliferation and Maturation of Thymic Epithelial Progenitors

  2003cited by this paper
• Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence.

  2003cited by this paper
• Involvement of growth factors in thymic involution

  2003cited by this paper
• Neurotrophins and the immune system

  2003cited by this paper
• Interleukin-7: from bench to clinic.

  2002cited by this paper
• Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments.

  2002cited by this paper
• Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation.

  2002cited by this paper
• Current concepts of thymic aging

  2002cited by this paper
• Interleukin 7 worsens graft-versus-host disease.

  2002cited by this paper
• T cells and aging, January 2002 update.

  2002cited by this paper
• Telomerase in the human organism

  2002cited by this paper
• Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study.

  2002cited by this paper
• Upregulation of TrkA neurotrophin receptor expression in the thymic subcapsular, paraseptal, perivascular, and cortical epithelial cells during thymus regeneration

  2002cited by this paper
• Molecular quantitation of thymic output in mice and the effect of IL‐7

  2002cited by this paper
• Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin‐1β

  2002cited by this paper
• Age-associated thymic atrophy is linked to a decline in IL-7 production.

  2002cited by this paper
• IL-7 and Not Stem Cell Factor Reverses Both the Increase in Apoptosis and the Decline in Thymopoiesis Seen in Aged Mice1

  2001cited by this paper
• Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study.

  2001cited by this paper
• Rejuvenation of degenerative thymus by oral melatonin administration and the antagonistic action of melatonin against hydroxyl radical‐induced apoptosis of cultured thymocytes in mice

  2001cited by this paper
• Immunosenescence: a review.

  2001cited by this paper
• Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential.

  2001cited by this paper
• IFN-γ-dependent transcription of MHC class II IA is impaired in macrophages from aged mice

  2001cited by this paper
• Presence and possible functional role of nerve growth factor in the thymus.

  2001cited by this paper
• Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease.

  2001cited by this paper
• Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.

  2001cited by this paper
• Efficient generation of human T cells from a tissue-engineered thymic organoid

  2000cited by this paper
• Changes in the expression of the nerve growth factor receptors TrkA and p75LNGR in the rat thymus with ageing and increased nerve growth factor plasma levels

  2000cited by this paper

• When wrinkles appear on the immune system can it be reversed?

  2020cites this paper