Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Biology of the Cell

• Publication date

  2006-11-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E06-04-0283PMID 17093061PMCID PMC1751311
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

  2006cited by this paper
• Essential roles for the FE65 amyloid precursor protein‐interacting proteins in brain development

  2006cited by this paper
• Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

  2005cited by this paper
• Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.

  2005cited by this paper
• The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.

  2005cited by this paper
• Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain

  2005cited by this paper
• Presenilin-Dependent Transcriptional Control of the A -Degrading Enzyme Neprilysin by Intracellular Domains of APP and APLP

  2005cited by this paper
• β-Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid β: A Feedforward Mechanism for Alzheimer's Disease

  2005cited by this paper
• Stg1 is a novel SM22/transgelin‐like actin‐modulating protein in fission yeast

  2005cited by this paper
• Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

  2005cited by this paper
• Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

  2005influential reference
• The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

  2004cited by this paper
• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation*

  2004cited by this paper
• Pathways towards and away from Alzheimer's disease

  2004cited by this paper
• A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment.

  2004cited by this paper
• Apoptosis by Par-4 in cancer and neurodegenerative diseases.

  2003cited by this paper
• The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton.

  2003cited by this paper
• C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

  2003cited by this paper
• Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.

  2003cited by this paper
• The Amyloid Precursor Protein and Its Regulatory Protein, FE65, in Growth Cones and Synapses In Vitro and In Vivo

  2003cited by this paper
• gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.

  2003cited by this paper
• Proteasome‐mediated degradation of the C‐terminus of the Alzheimer's disease β‐amyloid protein precursor: Effect of C‐terminal truncation on production of β‐amyloid protein

  2003cited by this paper
• C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression

  2003influential reference
• Neuregulin–1 and ErbB4 Immunoreactivity Is Associated with Neuritic Plaques in Alzheimer Disease Brain and in a Transgenic Model of Alzheimer Disease

  2003cited by this paper
• Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

  2003cited by this paper
• A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

  2002cited by this paper
• The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.

  2002cited by this paper
• A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

  2002cited by this paper
• Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

  2002cited by this paper
• MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.

  2002cited by this paper
• Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease

  2002cited by this paper
• Changes in Expression of Amyloid Precursor Protein and Interleukin-1β after Experimental Traumatic Brain Injury in Rats

  2002cited by this paper
• Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)*

  2002cited by this paper
• Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

  2002cited by this paper
• A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase.

  2001cited by this paper
• Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch.

  2001cited by this paper
• A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

  2001cited by this paper
• Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ

  2001cited by this paper
• The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

  2001cited by this paper
• The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

  2001cited by this paper
• The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner*

  2001cited by this paper
• A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

  2001cited by this paper
• Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

  2001cited by this paper
• Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model.

  2000cited by this paper
• Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.

  2000cited by this paper
• The Role of Presenilin-1 in the γ-Secretase Cleavage of the Amyloid Precursor Protein of Alzheimer's Disease*

  2000cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

  1999cited by this paper
• The Fe65 Adaptor Protein Interacts through Its PID1 Domain with the Transcription Factor CP2/LSF/LBP1*

  1998cited by this paper
• The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of DrosophilaEnabled*

  1997cited by this paper
• The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system.

  1996cited by this paper
• Normal and abnormal biology of the beta-amyloid precursor protein.

  1994cited by this paper
• Appearance of localized immunoreactivity for the alpha 4 integrin subunit and for fibronectin in brains from Alzheimer's, Lewy body dementia patients and aged controls.

  1994cited by this paper
• Appearance of localized immunoreactivity for the α4 integrin subunit and for fibronectin in brains from Alzheimer's, Lewy body dementia patients and aged controls

  1994cited by this paper
• Hirano Bodies Accumulate C-Terminal Sequences of ß-Amyloid Precursor Protein (ß-APP) Epitopes

  1993cited by this paper
• Early and rapid de novo synthesis of Alzheimer βA4‐Amyloid precursor protein (APP) in activated microglia

  1993cited by this paper
• Hirano bodies accumulate C-terminal sequences of beta-amyloid precursor protein (beta-APP) epitopes.

  1993cited by this paper
• The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

  1991cited by this paper
• Immunochemical demonstration of tropomyosin in the neurofibrillary pathology of Alzheimer's disease.

  1990cited by this paper

• Graph Attention Based Prioritization of Disease Responsible Genes from Multimodal Alzheimer's Network

  2026cites this paper
• Network-based analysis of Alzheimer's Disease genes using multi-omics network integration with graph diffusion

  2025cites this paper
• Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65

  2025cites this paper
• Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes

  2024cites this paper
• The AICD interactome: implications in neurodevelopment and neurodegeneration

  2024cites this paper
• The study of Alzheimer's disease risk diagnosis based on natural killer cell marker genes in the multi-omics data

  2024cites this paper
• Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.

  2024cites this paper
• The Drosophila homolog of APP promotes Dscam expression to drive axon terminal growth, revealing interaction between Down syndrome genes

  2023cites this paper
• A role for APP in the development of astrocyte morphological complexity

  2023cites this paper
• A proteomic atlas of kidney amyloidosis provides insights into disease pathogenesis.

  2023cites this paper
• Knockdown of Amyloid Precursor Protein: Biological Consequences and Clinical Opportunities

  2022cites this paper
• Is Nucleoredoxin a Master Regulator of Cellular Redox Homeostasis? Its Implication in Different Pathologies

  2022cites this paper
• Amyloid precursor protein intra-cellular domain (AICD), Aβ and their confounding synergistic effects differentially regulate the degradome of cellular models of Alzheimer's disease

  2021cites this paper
• An Amyloid Agnostic Reformulation of the Alzheimer’s Disease: The Long Gene Vulnerability Hypothesis

  2021cites this paper
• Fe65: A Scaffolding Protein of Actin Regulators

  2021cites this paper
• An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

  2020cites this paper
• Interaction of Sp1 and APP promoter elucidates a mechanism for Pb2+ caused neurodegeneration.

  2020cites this paper
• A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites

  2019cites this paper
• Designing and preparation of new BACE1 inhibitors for Alzheimer's disease treatment

  2019cites this paper
• Dystonin/BPAG1 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis

  2019cites this paper
• The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons

  2018cites this paper
• The MICALs are a Family of F-actin Dismantling Oxidoreductases Conserved from Drosophila to Humans

  2018cites this paper
• Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity

  2017cites this paper
• Mutational burden of giant synaptic genes may be the cause of Alzheimer’s disease

  2017cites this paper
• Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer's disease

  2017cites this paper
• Molecular Mechanisms of Synaptic Plasticity and Memory and Their Dysfunction in Alzheimer's Disease

  2017cites this paper
• Alzheimer's Disease and Histone Code Alterations.

  2017cites this paper
• Defining the function of Amyloid Precursor Protein dimerisation in neuritogenesis

  2017cites this paper
• Alzheimer's disease: the large gene instability hypothesis

  2017cites this paper
• Nitric Oxide: Exploring the Contextual Link with Alzheimer's Disease

  2016cites this paper
• Actin filaments—A target for redox regulation

  2016cites this paper
• Role of Drosophila Amyloid Precursor Protein in Memory Formation

  2016cites this paper
• Tip60 HAT Action Mediates Environmental Enrichment Induced Cognitive Restoration

  2016cites this paper
• The Amyloid β Precursor Protein and Cognitive Function in Alzheimer’s Disease

  2016cites this paper
• Studying the Interactions Between Tau, Amyloid, and α-Synuclein in Alzheimer’s Disease Animal and Human Cell Models

  2016cites this paper
• Endogenous Regulators of Gamma-Secretase and Amyloid-Beta Production, and Engineering of Alzheimer"s Disease Therapeutic Tools

  2016cites this paper
• Extensive nuclear sphere generation in the human Alzheimer's brain.

  2016cites this paper
• Nuclear spheres modulate the expression of BEST1 and GADD45G.

  2016cites this paper
• The keystone of Alzheimer pathogenesis might be sought in Aβ physiology.

  2015influential citation
• Expediting the Discovery and Potential Translation of Theranostic Agents for Alzheimer's Disease

  2015cites this paper
• The amyloid precursor protein shows a pH-dependent conformational switch in its E1 domain.

  2015cites this paper
• Expression of human amyloid precursor protein in Drosophila melanogaster nerve cells causes a decrease in presynaptic gene mRNA levels.

  2015cites this paper
• APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression

  2015cites this paper
• Transcriptomic Analysis of Drosophila Mushroom Body Neurons Lacking Amyloid-β Precursor-Like Protein Activity

  2015cites this paper
• Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles*

  2015cites this paper
• Tip off the HAT– Epigenetic control of learning and memory by Drosophila Tip60

  2015cites this paper
• Mutants of metal binding site M1 in APP E2 show metal specific differences in binding of heparin but not of sorLA.

  2015cites this paper
• RanBP9 Modulates AICD Localization and Transcriptional Activity via Direct Interaction with Tip60

  2014cites this paper
• The structural biology of the amyloid precursor protein APP – a complex puzzle reveals its multi-domain architecture

  2014cites this paper
• Pharmacological targeting of the β-amyloid precursor protein intracellular domain

  2014cites this paper
• Expression of cytoskeletal and molt-related genes is temporally scheduled in the hypodermis of the crayfish Procambarus clarkii during premolt

  2014cites this paper
• Pharmacological targeting of the b-amyloid precursor protein intracellular

  2014cites this paper
• TDP-43 interaction with the intracellular domain of amyloid precursor protein induces p53-associated apoptosis.

  2014cites this paper
• PATHOGENIC ROLE OF MICROGLIA-DERIVED MICROVESICLES IN NEURODEGENERATION

  2014cites this paper
• The Aβ‐clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain

  2014cites this paper
• Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action

  2014cites this paper
• Differential expression of ARID3B in normal adult tissue and carcinomas.

  2014cites this paper
• Effect of human APP gene overexpression on Drosophila melanogaster cholinergic and dopaminergic brain neurons

  2014cites this paper
• ACE Inhibition with Captopril Retards the Development of Signs of Neurodegeneration in an Animal Model of Alzheimer’s Disease

  2013influential citation
• FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres – potential relevance to Alzheimer’s disease

  2013cites this paper
• Dropping the BACE: beta secretase (BACE1) as an Alzheimer’s disease intervention target

  2013cites this paper
• Redox proteomics gives insights into the role of oxidative stress in alkaptonuria

  2013cites this paper
• Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease

  2013cites this paper
• Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities

  2013cites this paper
• From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein

  2013cites this paper
• A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1.

  2013cites this paper
• UNIVERSITÀ DEGLI STUDI DI MILANO " Pathogenic role of microglia-derived microvesicles in Neurodegeneration " BIO / 14

  2013cites this paper
• The interaction between the neural cell adhesion molecule L1 and β-amyloid peptide : potential relevance in Alzheimer’s disease

  2013cites this paper
• The effects of piezoelectric polymers on neuronal differentiation

  2013cites this paper
• Amyloid Beta A4 Precursor Protein-binding Family B Member 1 (FE65) Interactomics Revealed Synaptic Vesicle Glycoprotein 2A (SV2A) and Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 (SERCA2) as New Binding Proteins in the Human Brain*

  2013cites this paper
• Physiological functions of APP family proteins.

  2012cites this paper
• Two memory associated genes regulated by amyloid precursor protein intracellular domain

  2012cites this paper
• The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis.

  2012cites this paper
• AβPP Intracellular C-Terminal Domain Function is Related to its Degradation Processes

  2012cites this paper
• The Amyloid Precursor Protein (APP) Family Members are Key Players in S-adenosyl-methionine Formation by MAT2A and Modify BACE1 and PSEN1 Gene Expression-Relevance for Alzheimer’s Disease*

  2012cites this paper
• Analysis of amyloid precursor protein function in Drosophilamelanogaster

  2012cites this paper
• Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model

  2012cites this paper
• All in the Family: How the APPs Regulate Neurogenesis

  2012cites this paper
• ACIN1-apoptotic chromatin condensation inducer in the nucleus AD-Alzheimer’s disease AICD-amyloid precursor protein intracellular domain APLP1-amyloid precursor-like protein 1 APLP2-amyloid precursor-like protein 2 APP-amyloid precursor protein ASA-amino acid analysis

  2012cites this paper
• MODEL HIRANO BODIES DIFFERENTIALLY MODULATE CELL DEATH INDUCED BY TAU AND THE AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN by WILLIAM EUGENE SPEARS

  2012cites this paper
• Human APP gene expression in nerve cells of Drosophila melanogaster causes alteration of synaptoptagmin 1 mRNA level

  2012cites this paper
• Characterization of amyloid-β precursor protein intracellular domain-associated transcriptional complexes in SH-SY5Y neurocytes

  2012cites this paper
• Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth

  2012cites this paper
• AICD nuclear signaling and its possible contribution to Alzheimer's disease.

  2012cites this paper
• The physiology of the β‐amyloid precursor protein intracellular domain AICD

  2012cites this paper
• The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

  2012cites this paper
• Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

  2012cites this paper
• Nuclear signalling by membrane protein intracellular domains: the AICD enigma.

  2012cites this paper
• The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth.

  2012cites this paper
• Novel aspects of the apolipoprotein-E receptor family: regulation and functional role of their proteolytic processing

  2012cites this paper
• The Amyloid Precursor Protein (APP) Family Members are Key Players in S-adenosylmethionine Formation by MAT2A and Modify BACE1 and PSEN1 Gene Expression-Relevance for Alzheimer's Disease*

  2012cites this paper
• Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity.

  2012cites this paper
• Role of the 39-kDa receptor-associated protein (RAP) in Alzheimer's disease

  2012cites this paper
• Dysregulation of Ca 2 signaling in astrocytes from mice lacking amyloid precursor protein

  2011cites this paper
• Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform

  2011cites this paper
• Use of proteomic differential displays to assess functional discrepancies and adjustments of human bone marrow- and Wharton jelly-derived mesenchymal stem cells.

  2011cites this paper
• Alzheimer’s disease: ageing-related or age-related? New hypotheses from an old debate

  2011cites this paper
• Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity.

  2011cites this paper
• The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.

  2011cites this paper
• Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.

  2011cites this paper