Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

Neutrophils are essential effector cells in the host defense against invading pathogens. Recently, novel neutrophil functions have emerged in addition to their classical anti-microbial role. One of these functions is the suppression of T cell responses. In this respect, neutrophils share similarities with granulocytic myeloid-derived suppressor cells (G-MDSCs). In this review, we will discuss the similarities and differences between neutrophils and G-MDSCs. Various types of G-MDSCs have been described, ranging from immature to mature cells shaping the immune response by different immune suppressive mechanisms. However, all types of G-MDSCs share distinct features of neutrophils, such as surface markers and morphology. We propose that G-MDSCs are heterogeneous and represent novel phenotypes of neutrophils, capable of suppressing the immune response. In this review, we will attempt to clarify the differences and similarities between neutrophils and G-MDSCs and attempt to facilitate further research.

• Publication year

  2013

• Venue

  Cellular and Molecular Life Sciences

• Publication date

  2013-02-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00018-013-1286-4PMID 23423530PMCID 3781313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Supplementary Figure S1

  2019cited by this paper
• Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells.

  2013cited by this paper
• Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

  2012cited by this paper
• Characterization of the nature of granulocytic myeloid‐derived suppressor cells in tumor‐bearing mice

  2012cited by this paper
• On the armament and appearances of human myeloid-derived suppressor cells.

  2012cited by this paper
• Acquisition of Antigen-Presenting Functions by Neutrophils Isolated from Mice with Chronic Colitis

  2012cited by this paper
• Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release

  2012influential reference
• Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin

  2012cited by this paper
• Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.

  2012cited by this paper
• Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth

  2012cited by this paper
• NK Cell Response to Vaccinia Virus Is Regulated by Myeloid-Derived Suppressor Cells

  2012cited by this paper
• Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes.

  2012cited by this paper
• Exercise Increases the Frequency of Circulating Hematopoietic Progenitor Cells, But Reduces Hematopoietic Colony-Forming Capacity

  2012cited by this paper
• Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology

  2012influential reference
• CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer.

  2012cited by this paper
• Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking.

  2012cited by this paper
• A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.

  2012influential reference
• The historical milestones in the understanding of leukocyte biology initiated by Elie Metchnikoff

  2011cited by this paper
• Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

  2011cited by this paper
• Junctional adhesion molecule-C (JAM-C) regulates polarized neutrophil transendothelial cell migration in vivo

  2011cited by this paper
• Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish

  2011cited by this paper
• Myeloid‐derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties

  2011cited by this paper
• Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

  2011cited by this paper
• Failure to detect production of IL-10 by activated human neutrophils

  2011cited by this paper
• Neutrophils, Not Monocyte/Macrophages, are the Major Splenic Source of Postburn IL-10

  2011cited by this paper
• Exocytosis of azurophil and arginase 1‐containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation

  2011cited by this paper
• Identification of Myeloid Derived Suppressor Cells in Dogs with Naturally Occurring Cancer

  2011cited by this paper
• Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation.

  2011cited by this paper
• In vivo suppressive function of myeloid‐derived suppressor cells is limited to the inflammatory site

  2011cited by this paper
• B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen

  2011cited by this paper
• Deuterium and neutrophil kinetics.

  2011cited by this paper
• Measuring whole‐body neutrophil redistribution using a dedicated whole‐body counter and ultra‐low doses of 111Indium

  2011cited by this paper
• IL‐1β regulates a novel myeloid‐derived suppressor cell subset that impairs NK cell development and function

  2010cited by this paper
• Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants

  2010cited by this paper
• Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.

  2010influential reference
• Arginine: Master and Commander in Innate Immune Responses

  2010cited by this paper
• SnapShot: Reactive Oxygen Intermediates (ROI).

  2010cited by this paper
• Two Sides of the Same Coin

  2010cited by this paper
• Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

  2010cited by this paper
• Myeloid-derived suppressor cell heterogeneity and subset definition.

  2010cited by this paper
• In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days.

  2010cited by this paper
• Human eosinophil granulocytes do not express the enzyme arginase

  2010cited by this paper
• Nature of myeloid cells expressing arginase 1 in peripheral blood after trauma.

  2009cited by this paper
• Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.

  2009cited by this paper
• Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism

  2009cited by this paper
• IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer Patients1

  2009cited by this paper
• Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14−/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer

  2009cited by this paper
• Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death.

  2009cited by this paper
• Myeloid-derived suppressor cells as regulators of the immune system

  2009cited by this paper
• Cutting Edge: Contribution of Lung-Resident T Cell Proliferation to the Overall Magnitude of the Antigen-Specific CD8 T Cell Response in the Lungs following Murine Influenza Virus Infection1

  2009cited by this paper
• [Effects of extracts of cheezheng pain relieving plaster on nitric oxide and iNOS expression in macrophages induced by lipopolysaccharides].

  2009cited by this paper
• A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

  2009cited by this paper
• Myeloid‐derived suppressor cell activation by combined LPS and IFN‐γ treatment impairs DC development

  2009cited by this paper
• Measurement of Neutrophil Pulmonary Transit Time in Humans.

  2009cited by this paper
• Lung cancer patients’ CD4+ T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells

  2008cited by this paper
• Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.

  2008cited by this paper
• Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions.

  2008cited by this paper
• H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

  2008cited by this paper
• Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines

  2008cited by this paper
• Dynamics of neutrophil migration in lymph nodes during infection.

  2008cited by this paper
• The actin cytoskeleton in T cell activation.

  2008cited by this paper
• Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues

  2008cited by this paper
• Neutrophils Clear Bacteria Associated with Parasitic Nematodes Augmenting the Development of an Effective Th2-Type Response1

  2008cited by this paper
• Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

  2008cited by this paper
• Use of Ly6G‐specific monoclonal antibody to deplete neutrophils in mice

  2008influential reference
• Proliferative Expansion and Acquisition of Effector Activity by Memory CD4+ T Cells in the Lungs following Pulmonary Virus Infection1

  2008cited by this paper
• Cellular Responses in Sea Fan Corals: Granular Amoebocytes React to Pathogen and Climate Stressors

  2008cited by this paper
• Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes1

  2008cited by this paper
• CD8+ T Cell Responses in Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells of Infants with Severe Primary Respiratory Syncytial Virus Infections1

  2007cited by this paper
• The terminology issue for myeloid-derived suppressor cells.

  2007cited by this paper
• L-arginine availability regulates T-lymphocyte cell-cycle progression.

  2007cited by this paper
• Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.

  2007cited by this paper
• Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation.

  2007cited by this paper
• Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.

  2007cited by this paper
• MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis

  2007cited by this paper
• Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma

  2007cited by this paper
• Presence of neutrophil-bearing antigen in lymphoid organs of immune mice.

  2006cited by this paper
• Neutrophils and immunity: challenges and opportunities

  2006influential reference
• Identification of a phenotypically and functionally distinct population of long‐lived neutrophils in a model of reverse endothelial migration

  2006cited by this paper
• A study of CD33 (SIGLEC‐3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing

  2006cited by this paper
• Migratory monocytes and granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node

  2006cited by this paper
• Persistence and responsiveness of immunologic memory in the absence of secondary lymphoid organs.

  2006cited by this paper
• T cell surface redox levels determine T cell reactivity and arthritis susceptibility

  2006cited by this paper
• CD11b+/Gr-1+ Myeloid Suppressor Cells Cause T Cell Dysfunction after Traumatic Stress1

  2006cited by this paper
• L-arginine improves wound healing after trauma-hemorrhage by increasing collagen synthesis.

  2005cited by this paper
• Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.

  2005cited by this paper
• Frequency, Specificity, and Sites of Expansion of CD8+ T Cells during Primary Pulmonary Influenza Virus Infection1

  2005cited by this paper
• Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.

  2005cited by this paper
• Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

  2005cited by this paper
• Mouse bone marrow contains large numbers of functionally competent neutrophils

  2004cited by this paper
• Regulation of T cell receptor CD3zeta chain expression by L-arginine.

  2002cited by this paper
• Regulation of Constitutive TCR Internalization by the ζ-Chain

  2002cited by this paper
• Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1(+))CD11b(+ )immature myeloid suppressor cells.

  2002influential reference
• Regulation of constitutive TCR internalization by the zeta-chain.

  2002cited by this paper
• Surface antigen changes during normal neutrophilic development: a critical review.

  2002cited by this paper
• Regulation of T Cell Receptor CD3ζ Chain Expression byl-Arginine*

  2002cited by this paper
• Regulation of human neutrophil granule protein expression.

  2001cited by this paper
• Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

  2001influential reference
• Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells1

  2001cited by this paper
• Inhibition of Activated/Memory (CD45RO+) T Cells by Oxidative Stress Associated with Block of NF-κB Activation1

  2001cited by this paper

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  2026cites this paper
• High-dimensional single-cell analyses reveal neutrophil heterogeneity in guttate psoriasis.

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• Tissue damage, myocardial injury and recruitment of mature and banded neutrophils after high-intensity endurance exercise.

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• Neutrophil Spatiotemporal Regulatory Networks: Dual Roles in Tumor Growth Regulation and Metastasis

  2025cites this paper
• T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.

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• Different In Vitro Models of Chronic Myeloid Leukemia Show Different Characteristics: Biological Replicates Are Not Biologically Equivalent

  2025cites this paper
• Helminth infection favors reprogramming and proliferation of lung neutrophils

  2025cites this paper
• Subtypes of tumor-associated neutrophils and their roles in cancer immunotherapy.

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• IL‐13 From Murine Epidermal γδ T Cells Promotes Wound Healing by Inducing Arginase‐1‐Positive Hypodermal Macrophages in the Early Inflammatory Phase

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• Metabolic phenotype of bovine blood-derived neutrophils is altered in milk

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• Mitochondrial Oxidative Stress in Circulating Leukocytes as a Prognostic Marker in Hepatocellular Carcinoma

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• Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity.

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• Complement regulators as novel targets for anti-cancer therapy: A comprehensive review.

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