Aquaporins in Salivary Glands: From Basic Research to Clinical Applications

Salivary glands are involved in saliva secretion that ensures proper oral health. Aquaporins are expressed in salivary glands and play a major role in saliva secretion. This review will provide an overview of the salivary gland morphology and physiology of saliva secretion, and focus on the expression, subcellular localization and role of aquaporins under physiological and pathophysiological conditions, as well as clinical applications involving aquaporins. This review is highlighting expression and localization of aquaporins in human, rat and mouse, the most studied species and is pointing out possible difference between major salivary glands, i.e., parotid, submandibular and sublingual glands.

• Publication year

  2016

• Venue

  International Journal of Molecular Sciences

• Publication date

  2016-01-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/ijms17020166PMID 26828482PMCID 4783900
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Abnormal distribution of AQP5 in labial salivary glands is associated with poor saliva secretion in patients with Sjögren's syndrome including neuromyelitis optica complicated patients

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  2015cited by this paper
• Effect of Antimuscarinic Autoantibodies in Primary Sjögren’s Syndrome

  2015cited by this paper
• Physiological role of aquaporin 5 in salivary glands

  2015cited by this paper
• Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sjögren's syndrome.

  2015cited by this paper
• Salivary Glands

  2015cited by this paper
• Crosstalk between purinergic receptors and canonical signaling pathways in the mouse salivary gland.

  2015cited by this paper
• IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome

  2015cited by this paper
• Meta‐Analysis of Salivary Flow Rates in Young and Older Adults

  2015cited by this paper
• Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter

  2015cited by this paper
• Activation of muscarinic receptors in rat parotid acinar cells induces AQP5 trafficking to nuclei and apical plasma membrane.

  2015cited by this paper
• Aquaporins in salivary glands and pancreas.

  2014cited by this paper
• Immunolocalization of AQP 5 in resting and stimulated normal labial glands and in Sj € ogren ’ s syndrome

  2014cited by this paper
• Ca²⁺ signaling and regulation of fluid secretion in salivary gland acinar cells.

  2014cited by this paper
• Establishment and Characterization of Mesenchymal Stem Cell-Like Clonal Stem Cells from Mouse Salivary Glands

  2014cited by this paper
• Calcium signaling and cell volume regulation are altered in Sjögren's Syndrome

  2014cited by this paper
• A comprehensive review of autoantibodies in primary Sjögren's syndrome: clinical phenotypes and regulatory mechanisms.

  2014cited by this paper
• Multiscale modelling of saliva secretion.

  2014cited by this paper
• The role of mammalian superaquaporins inside the cell.

  2014cited by this paper
• The secretion, components, and properties of saliva.

  2013influential reference
• What Do Aquaporin Knockout Studies Tell Us about Fluid Transport in Epithelia?

  2013cited by this paper
• Sjögren's syndrome and the epithelial target: a comprehensive review.

  2013cited by this paper
• Aquaporins in the adult mouse submandibular and sublingual salivary glands

  2013influential reference
• Concise Review: Adult Salivary Gland Stem Cells and a Potential Therapy for Xerostomia

  2013cited by this paper
• Autoantibodies against Muscarinic Type 3 Receptor in Sjögren's Syndrome Inhibit Aquaporin 5 Trafficking

  2013cited by this paper
• Involvement of AQP6 in the Mercury-Sensitive Osmotic Lysis of Rat Parotid Secretory Granules

  2013cited by this paper
• An immunohistochemistry-based study on aquaporin (AQP)-1, 3, 4, 5 and 8 in the parotid glands, submandibular glands and sublingual glands of Sjögren's syndrome mouse models chronically administered cevimeline.

  2013cited by this paper
• Pathophysiological cytokine network in primary Sjögren's syndrome.

  2012cited by this paper
• Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction

  2012cited by this paper
• Link between inflammation and aquaporin-5 distribution in submandibular gland in Sjögren's syndrome?

  2012cited by this paper
• Anatomy and Histology of Rodent and Human Major Salivary Glands

  2012cited by this paper
• Relationship between aquaporin-5 expression and saliva flow in streptozotocin-induced diabetic mice?

  2012cited by this paper
• DNA Demethylating Agent Decitabine Increases AQP5 Expression and Restores Salivary Function

  2012cited by this paper
• Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.

  2012influential reference
• E2f1-deficient NOD/SCID mice have dry mouth due to a change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland

  2012cited by this paper
• Efficiency of Primary Saliva Secretion: An Analysis of Parameter Dependence in Dynamic Single-Cell and Acinus Models, with Application to Aquaporin Knockout Studies

  2012cited by this paper
• TNF-α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation

  2012cited by this paper
• Cell surface markers CD44 and CD166 localized specific populations of salivary acinar cells.

  2012cited by this paper
• Primary Sjögren’s syndrome: current pathophysiological, diagnostic and therapeutic advances

  2011cited by this paper
• Localization of AQP5 during development of the mouse submandibular salivary gland

  2011cited by this paper
• Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice.

  2011cited by this paper
• Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats.

  2011cited by this paper
• Managing the patient presenting with xerostomia: a review

  2010cited by this paper
• Apoptosis and Expression of AQP5 and TGF-β in the Irradiated Rat Submandibular Gland

  2010cited by this paper
• Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos.

  2010cited by this paper
• The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.

  2010cited by this paper
• Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG

  2009cited by this paper
• Purinergic P2X7 Receptors Mediate ATP-induced Saliva Secretion by the Mouse Submandibular Gland*

  2009cited by this paper
• SALIVATION TRIGGERED BY PILOCARPINE INVOLVES AQUAPORIN‐5 IN NORMAL RATS BUT NOT IN IRRADIATED RATS

  2009cited by this paper
• Apoptosis and expression of AQP5 and TGF-beta in the irradiated rat submandibular gland.

  2009cited by this paper
• A current view of the mammalian aquaglyceroporins.

  2008cited by this paper
• A Review of Scientific Papers About Head and Neck Cancers

  2008cited by this paper
• Primary Sjogren's syndrome: current and prospective therapies.

  2008cited by this paper
• Emerging biological therapies in primary Sjogren's syndrome.

  2007cited by this paper
• Regulation of salivary gland function by autonomic nerves.

  2007cited by this paper
• Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy.

  2007cited by this paper
• Functional domains of aquaporin-1: keys to physiology, and targets for drug discovery.

  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Changes of aquaporin 5-distribution during release and reaccumulation of secretory granules in isoproterenol-treated mouse parotid gland.

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• AQP and the Control of Fluid Transport in a Salivary Gland

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  2006cited by this paper
• Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.

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• A New Approach to Epithelial Isotonic Fluid Transport: An Osmosensor Feedback Model

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• Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

  2005influential reference
• Phenotype analysis of aquaporin-8 null mice.

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• Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome

  2004cited by this paper
• Aquaporin water channels (Nobel Lecture).

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  2001influential reference
• Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways.

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  2000cited by this paper
• Opening the Flood Gates

  2000cited by this paper
• Opening the flood gates: interferon-alpha treatment for Sjögren's syndrome.

  2000cited by this paper
• Expression of aquaporin 1 (AQP1) water channels in human labial salivary glands.

  1999cited by this paper
• Morphological features of the minor salivary glands.

  1999cited by this paper
• Aquaporin-5 (AQP5), a water channel protein, in the rat salivary and lacrimal glands: immunolocalization and effect of secretory stimulation

  1999cited by this paper
• Interferon-alpha Upregulates Gene Expression of Aquaporin-5 in Human Parotid Glands

  1999cited by this paper
• Defective Secretion of Saliva in Transgenic Mice Lacking Aquaporin-5 Water Channels*

  1999influential reference
• Treatment of Primary Sjogren's Syndrome with Low-Dose Natural Human Interferon-alpha Administered by the Oral Mucosal Route: A Phase II Clinical Trial

  1999cited by this paper

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• Molecular Architects of Dental Caries: Genes, Proteins, and Cellular Pathway Perspectives: A Systematic Review

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• Study on the mechanism of radioactive salivary gland injury: a relatively comprehensive statement.

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• Akuaporinlerin Gözdeki Değeri

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• AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein

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• Evaluation of AQP5 in Hypomineralized Teeth in Comparison to Normal Teeth: A Cross-sectional Study

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• Aquaporins in bovine male reproductive tract: From calves to reproductive bulls.

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• Morphology, glicohistochemistry and immunolocalization of Aquaporin 5 in the mandibular gland of the giant anteater (Myrmecophaga tridactyla).

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• ARL13B controls male reproductive tract physiology through primary and Motile Cilia

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• Improvement effect of gemigliptin on salivary gland dysfunction in exogenous methylglyoxal-injected rats

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• Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

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• Plant Molecular Farming-derived Epidermal Growth Factor Revolutionizes Hydrogels for Improving Glandular Epithelial Organoid Biofabrication.

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  2023cites this paper
• Developmental function of Piezo1 in mouse submandibular gland morphogenesis

  2023cites this paper
• Involvement of aquaporin 5 in Sjögren's syndrome.

  2023cites this paper
• Apigenin, a Single Active Component of Herbal Extract, Alleviates Xerostomia via ERα-Mediated Upregulation of AQP5 Activation

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• A novel association of osmotic demyelination in Sjögren's syndrome prompts revisiting role of aquaporins in CNS demyelinating diseases: A literature review.

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• Molecular Mechanisms Linking Inflammation to Autoimmunity in Sjögren’s Syndrome: Identification of New Targets

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• In Vivo Transfection of Rat Salivary Glands With Fluorescently Tagged Aquaporin-5 Channel DNA

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• Peptide: N-glycanase 1 and its relationship with con- genital disorder of deglycosylation

  2022cites this paper
• [Effects of acid stimulation on saliva flow rate and compositions of human parotid and submandibular glands].

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• Aquaporins; systemic, functional and therapeutic correlations in health and disease.

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• FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland

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• Human dental pulp stem cells attenuate streptozotocin-induced parotid gland injury in rats

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  2020cites this paper
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• Reduced myofilament component in primary Sjögren’s syndrome salivary gland myoepithelial cells

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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