Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neurobiology of Disease

• Publication date

  2010-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.nbd.2010.07.018PMID 20691786PMCID PMC3031166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?

  2009cited by this paper
• Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

  2009cited by this paper
• Neuronal Transporters Regulate Glutamate Clearance, NMDA Receptor Activation, and Synaptic Plasticity in the Hippocampus

  2009cited by this paper
• Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

  2009influential reference
• Uniquely Hominid Features of Adult Human Astrocytes

  2009cited by this paper
• Astrocytes in the epileptic brain.

  2008cited by this paper
• Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

  2008cited by this paper
• Developmental profile and properties of sulforhodamine 101--Labeled glial cells in acute brain slices of rat hippocampus.

  2008cited by this paper
• Loss of Astrocytic Domain Organization in the Epileptic Brain

  2008cited by this paper
• Glutamate transporters: confining runaway excitation by shaping synaptic transmission

  2007influential reference
• Astrocyte membrane responses and potassium accumulation during neuronal activity

  2007cited by this paper
• Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro.

  2007cited by this paper
• Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex.

  2007cited by this paper
• Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injury.

  2007cited by this paper
• Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation

  2007cited by this paper
• Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses

  2006cited by this paper
• The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus

  2006cited by this paper
• Long-Term Potentiation of Neuron-Glia Synapses Mediated by Ca2+-Permeable AMPA Receptors

  2006cited by this paper
• Shapes of astrocyte networks in the juvenile brain.

  2006cited by this paper
• A Spontaneous Mutation Involving Kcnq2 (Kv7.2) Reduces M-Current Density and Spike Frequency Adaptation in Mouse CA1 Neurons

  2006cited by this paper
• Development of gap junctions in hippocampal astrocytes: evidence that whole cell electrophysiological phenotype is an intrinsic property of the individual cell.

  2006cited by this paper
• Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex

  2006cited by this paper
• Effect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons.

  2006cited by this paper
• Astrocyte dysfunction in neurological disorders: a molecular perspective

  2006cited by this paper
• Functional changes in astroglial cells in epilepsy

  2006cited by this paper
• Faculty Opinions recommendation of Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors.

  2006cited by this paper
• Deriving the Glutamate Clearance Time Course from Transporter Currents in CA1 Hippocampal Astrocytes: Transmitter Uptake Gets Faster during Development

  2005influential reference
• Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity

  2005cited by this paper
• Emerging complexities in identity and function of glial connexins.

  2005cited by this paper
• Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo

  2004cited by this paper
• Synaptosomal glutamate and GABA transport in patients with temporal lobe epilepsy

  2004cited by this paper
• Kir4.1 expression by astrocytes and oligodendrocytes in CNS white matter: a developmental study in the rat optic nerve

  2004cited by this paper
• Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis.

  2004influential reference
• Distinct types of astroglial cells in the hippocampus differ in gap junction coupling

  2004cited by this paper
• Potassium buffering in the central nervous system.

  2004influential reference
• Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility.

  2004cited by this paper
• Connexin43 is not expressed in principal cells of mouse cortex and hippocampus

  2003cited by this paper
• Segregated Expression of AMPA-Type Glutamate Receptors and Glutamate Transporters Defines Distinct Astrocyte Populations in the Mouse Hippocampus

  2003cited by this paper
• The Role of Glial Glutamate Transporters in Maintaining the Independent Operation of Juvenile Mouse Cerebellar Parallel Fibre Synapses

  2003cited by this paper
• Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine.

  2002cited by this paper
• Distribution of glutamate transporters in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy.

  2002cited by this paper
• Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy.

  2002cited by this paper
• Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains

  2002cited by this paper
• Increased Expression of the Neuronal Glutamate Transporter (EAAT3/EAAC1) in Hippocampal and Neocortical Epilepsy

  2002cited by this paper
• An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain.

  2001cited by this paper
• Electrophysiological characteristics of reactive astrocytes in experimental cortical dysplasia.

  2001cited by this paper
• Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery.

  2000cited by this paper
• Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS.

  2000cited by this paper
• Glial heterogeneity in expression of the inwardly rectifying K+ channel, Kir4.1, in adult rat CNS

  2000cited by this paper
• Effects of barium on stimulus‐induced rises of [K+]o in human epileptic non‐sclerotic and sclerotic hippocampal area CA1

  2000cited by this paper
• Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation.

  2000influential reference
• Kainate, a double agent that generates seizures: two decades of progress.

  2000cited by this paper
• Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances

  2000cited by this paper
• Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy

  1999cited by this paper
• Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity.

  1999cited by this paper
• Impaired K+ Homeostasis and Altered Electrophysiological Properties of Post-Traumatic Hippocampal Glia

  1999cited by this paper
• Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes

  1999cited by this paper
• Functional Specialization and Topographic Segregation of Hippocampal Astrocytes

  1998cited by this paper
• Glutamate release monitored with astrocyte transporter currents during LTP.

  1998cited by this paper
• Monitoring glutamate release during LTP with glial transporter currents.

  1998cited by this paper
• Extracellular space structure revealed by diffusion analysis.

  1998cited by this paper
• Properties of human glial cells associated with epileptic seizure foci.

  1998cited by this paper
• Effects of barium on stimulus-induced changes in [K+]o and field potentials in dentate gyrus and area CA1 of human epileptic hippocampus.

  1998cited by this paper
• Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy.

  1998cited by this paper
• DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.

  1998cited by this paper
• Diverse functions of vertebrate gap junctions.

  1998cited by this paper
• Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats.

  1998cited by this paper
• Heterogeneity of Astrocyte Resting Membrane Potentials and Intercellular Coupling Revealed by Whole-Cell and Gramicidin-Perforated Patch Recordings from Cultured Neocortical and Hippocampal Slice Astrocytes

  1997cited by this paper
• Reduction of K+ Uptake in Glia Prevents Long-Term Depression Maintenance and Causes Epileptiform Activity

  1997cited by this paper
• Alterations in Glutamate Transporter Protein Levels in Kindling‐Induced Epilepsy

  1997cited by this paper
• Metabolic trafficking through astrocytic gap junctions

  1997cited by this paper
• Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale

  1997cited by this paper
• Qualitative analysis of membrane currents in glial cells from normal and gliotic tissue in situ: down-regulation of Na+ current and lack of P2 purinergic responses.

  1997cited by this paper
• Synaptic activation of glutamate transporters in hippocampal astrocytes.

  1997influential reference
• Clinical evidence for the progressive nature of epilepsy.

  1996cited by this paper
• Astrocytic gap junction removal, connexin43 redistribution, and epitope masking at excitatory amino acid lesion sites in rat brain

  1995cited by this paper
• Human epileptic astrocytes exhibit increased gap junction coupling

  1995cited by this paper
• Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

  1995cited by this paper
• Biophysical and pharmacological characterization of inwardly rectifying K+ currents in rat spinal cord astrocytes.

  1995influential reference
• Properties of voltage-activated Na+ and K+ currents in mouse hippocampal glial cells in situ and after acute isolation from tissue slices

  1994cited by this paper
• Astrocytic dye coupling in rat hippocampus: Topography, developmental onset, and modulation by protein kinase C

  1994cited by this paper
• Localization of neuronal and glial glutamate transporters.

  1994cited by this paper
• Voltage‐dependent ion channels in glial cells

  1994cited by this paper
• Cloning and expression of a novel human brain inward rectifier potassium channel.

  1994cited by this paper
• Inward-rectifying potassium channels in retinal glial (Muller) cells

  1993influential reference
• Astrocytic and synaptic response to kindling in hippocampal subfield CA1. II. Synaptogenesis and astrocytic process increases to in vivo kindling.

  1993cited by this paper
• Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER.

  1993cited by this paper
• Gap junction gene expression in human seizure disorder.

  1991cited by this paper
• The neurobiology of disease

  1990cited by this paper
• Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice.

  1988cited by this paper
• Neuron/glia relationships observed over intervals of several months in living mice

  1988cited by this paper
• Ion activities and potassium uptake mechanisms of glial cells in guinea‐pig olfactory cortex slices.

  1987cited by this paper
• Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea‐pig heart.

  1984influential reference
• Dye coupling and possible electrotonic coupling in the guinea pig neocortical slice.

  1981cited by this paper
• Modification of seizure activity by electrical stimulation. II. Motor seizure.

  1972cited by this paper
• Modification of seizure activity by electrical stimulation. 3. Mechanisms.

  1972cited by this paper
• Silent cells during interictal discharges and seizures in hippocampal penicillin foci. Evidence for the role of extracellular K+ in the transition from the interictal state to seizures.

  1972cited by this paper
• Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.

  1966cited by this paper

• Cytoprotective and Immunomodulatory Properties of Mesenchymal Stem Cell Secretome and Its Effect on Organotypic Hippocampal Cultures in Mouse Model of Temporal Lobe Epilepsy

  2025cites this paper
• Comparative analysis of hippocampal extracellular space uncovers widely altered peptidome upon epileptic seizure in urethane-anaesthetized rats

  2024cites this paper
• Role of Impaired Astrocyte Gap Junction Coupling in Epileptogenesis

  2023cites this paper
• Astrocyte-neuron circuits in epilepsy

  2023cites this paper
• Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior

  2023cites this paper
• GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.

  2023cites this paper
• Epileptic activity triggers rapid ROCK1‐dependent astrocyte morphology changes

  2023cites this paper
• Assessment of bidirectional relationships between multiple sclerosis and epilepsy: A two-sample Mendelian randomization study.

  2023cites this paper
• Microglial TRPV1 in epilepsy: Is it druggable for new antiepileptic treatment?

  2023cites this paper
• Interactions between astrocytes and extracellular matrix structures contribute to neuroinflammation-associated epilepsy pathology

  2023cites this paper
• Chapter 41 Epilepsy *

  2022cites this paper
• Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus

  2022cites this paper
• Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats

  2022cites this paper
• Overview Article Astrocytes as Initiators of Epilepsy

  2022cites this paper
• The Gelatinase Inhibitor ACT-03 Reduces Gliosis in the Rapid Kindling Rat Model of Epilepsy, and Attenuates Inflammation and Loss of Barrier Integrity In Vitro

  2022cites this paper
• Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats

  2022cites this paper
• Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted Medicine

  2022cites this paper
• Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody‐associated disease

  2022cites this paper
• Differential effects of inhibitors of PTZ‐induced kindling on glutamate transporters and enzyme expression

  2021cites this paper
• Oops!...Glutamate Did it Again

  2021cites this paper
• SGK1.1 limits brain damage after status epilepticus through M current-dependent and independent mechanisms.

  2021cites this paper
• Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

  2021cites this paper
• An Astrocyte Structural Organization Analysis Based on Fluorescent Microscopy with 2D and 3D Quantitative Approaches

  2021cites this paper
• Neurobiology, Functions, and Relevance of Excitatory Amino Acid Transporters (EAATs) to Treatment of Refractory Epilepsy

  2020cites this paper
• Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

  2020cites this paper
• Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy.

  2020cites this paper
• Epileptiform Neuronal Discharges Impair Astrocyte Syncytial Isopotentiality in Acute Hippocampal Slices

  2020influential citation
• Astrocytes Keep It Under Wraps: Reconstructing Synapses in the Latent Phase of Epileptogenesis

  2020cites this paper
• Possible interplay between the theories of pharmacoresistant epilepsy

  2020cites this paper
• Astrocyte Glutamate Uptake and Water Homeostasis Are Dysregulated in the Hippocampus of Multiple Sclerosis Patients With Seizures

  2020cites this paper
• Astroglial connexins in epileptogenesis.

  2020cites this paper
• Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment

  2020cites this paper
• Glutamate Transporters (EAAT-1–3) as a Factor in the Pathogenesis and a Potential Therapeutic Target in Epilepsy

  2020cites this paper
• CDDO-Me Distinctly Regulates Regional Specific Astroglial Responses to Status Epilepticus via ERK1/2-Nrf2, PTEN-PI3K-AKT and NFκB Signaling Pathways

  2020cites this paper
• The Current Approach of the Epilepsy Therapy Screening Program Contract Site for Identifying Improved Therapies for the Treatment of Pharmacoresistant Seizures in Epilepsy.

  2019cites this paper
• Role of Astrocytes in Post-traumatic Epilepsy

  2019cites this paper
• Implication des connexines gliales dans les atteintes de la Neuromyélite Optique : un rôle dans la démyélinisation et les altérations neuronales

  2019cites this paper
• Astrocyte Receptor Rebirth

  2019cites this paper
• Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity.

  2019cites this paper
• Astroglial Cx30 sustains neuronal population bursts independently of gap‐junction mediated biochemical coupling

  2019cites this paper
• Human astrocytes in the diseased brain

  2018cites this paper
• Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy

  2018cites this paper
• Astroglial role in the pathophysiology of status epilepticus: an overview

  2018cites this paper
• Chapter 2 Astrocyte – Neuron Communications

  2018cites this paper
• Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake

  2018influential citation
• Connexins and pannexins: At the junction of neuro‐glial homeostasis & disease

  2018cites this paper
• Complex role of connexin 43 in astrocytic tumors and possible promotion of glioma‑associated epileptic discharge (Review).

  2017cites this paper
• Mathematical investigation of IP3-dependent calcium dynamics in astrocytes

  2017cites this paper
• Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss.

  2017cites this paper
• Elsevier Editorial System(tm) for Journal of Behavioral Brain Research

  2017cites this paper
• Systemic Administration of Connexin43 Mimetic Peptide Improves Functional Recovery after Traumatic Spinal Cord Injury in Adult Rats

  2017cites this paper
• Chronic demyelination-induced seizures.

  2017cites this paper
• Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

  2017cites this paper
• Chapter 7 – Potassium Channels

  2016cites this paper
• Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models

  2016cites this paper
• Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.

  2016cites this paper
• Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust.

  2016cites this paper
• Chapter 11 – Gap Junctions

  2016cites this paper
• Crucial role of astrocytes in temporal lobe epilepsy.

  2016cites this paper
• "Targeting astrocytes in CNS injury and disease: A translational research approach".

  2016cites this paper
• Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

  2015cites this paper
• Altered structure and function of astrocytes following status epilepticus.

  2015cites this paper
• Analysis of connexin expression during seizures induced by 4-aminopyridine in the rat hippocampus

  2015cites this paper
• Role of astrocytes in epilepsy.

  2015influential citation
• Glutamatergic Mechanisms Associated with Seizures and Epilepsy.

  2015influential citation
• Astrocytic Cx 43 and Cx 40 in the mouse hippocampus during and after pilocarpine-induced status epilepticus

  2015cites this paper
• Crucial Role for Astrocytes in Epilepsy

  2015cites this paper
• White Matter, and Cognitive Performance in Early Multiple Sclerosis Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting

  2015cites this paper
• Novel Viral asnd Astrocytic Contributors to Epilepsy

  2015cites this paper
• Ultrastructural changes to rat hippocampus in pentylenetetrazol- and kainic acid-induced status epilepticus: A study using electron microscopy.

  2015cites this paper
• Astrocytic Targets Provide New Avenues for the Therapeutic Treatment of Epilepsy

  2014cites this paper
• Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy.

  2014cites this paper
• The dual face of connexin-based astroglial Ca(2+) communication: a key player in brain physiology and a prime target in pathology.

  2014cites this paper
• Roles of gap junctions, connexins, and pannexins in epilepsy

  2014cites this paper
• Evidence for Aberrant Astrocyte Hemichannel Activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)

  2014cites this paper
• Novel astrocyte targets

  2014cites this paper
• Does brain inflammation mediate pathological outcomes in epilepsy?

  2014cites this paper
• Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion

  2014cites this paper
• Altered Kir and gap junction channels in temporal lobe epilepsy.

  2013cites this paper
• Lactation Reduces Glial Activation Induced by Excitotoxicity in the Rat Hippocampus

  2013cites this paper
• pH modulation of glial glutamate transporters regulates synaptic transmission in the nucleus of the solitary tract.

  2013cites this paper
• Emerging role for astroglial networks in information processing: from synapse to behavior.

  2013cites this paper
• Neuron-astrocyte signaling and epilepsy.

  2013influential citation
• Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation.

  2013influential citation
• Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury.

  2013cites this paper
• Astrocyte–Neuron Communications

  2013cites this paper
• Gap junction channels and hemichannels in the CNS: regulation by signaling molecules.

  2013cites this paper
• The use of connexin-based therapeutic approaches to target inflammatory diseases.

  2013cites this paper
• The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.

  2013cites this paper
• Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy?

  2013influential citation
• N w‐Propyl‐l‐arginine (L‐NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses

  2012cites this paper
• CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy.

  2012cites this paper
• Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

  2012influential citation
• Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex

  2012cites this paper
• Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis.

  2012cites this paper
• Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: A review

  2012cites this paper
• A cellular network of dye-coupled glia associated with the embryonic central complex in the grasshopper Schistocerca gregaria

  2012cites this paper
• Neuroinflammation alters voltage-dependent conductance in striatal astrocytes.

  2012cites this paper
• CARACTERIZACIÓN NEUROHISTOLÓGICA DEL HIPOCAMPO DE RATAS, INYECTADAS CON LA FRACCIÓN 3 DEL EXTRACTO ETANÓLICO DE BUNODOSOMA GRANULIFERA.

  2012cites this paper
• Mechanisms underlying blood–brain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia

  2012cites this paper