CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Nature Medicine

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/15233PMID 10545994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fibronectin interaction with alpha4beta1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax.

  1999cited by this paper
• Fibronectin interaction with α4β1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax

  1999cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999cited by this paper
• Dissociation of Phagocyte Recognition of Cells Undergoing Apoptosis from Other Features of the Apoptotic Program*

  1998cited by this paper
• Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia.

  1998cited by this paper
• PML induces a novel caspase-independent death process

  1998cited by this paper
• Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

  1998cited by this paper
• Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.

  1998cited by this paper
• Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes.

  1998cited by this paper
• E4orf4, a Novel Adenovirus Death Factor That Induces p53-independent Apoptosis by a Pathway That Is Not Inhibited by zVAD-fmk

  1998cited by this paper
• Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy.

  1998cited by this paper
• Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells.

  1998cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia.

  1998cited by this paper
• Dismantling in Cell Death: Molecular Mechanisms and Relationship to Caspase Activation

  1998cited by this paper
• Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells.

  1998cited by this paper
• Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

  1998cited by this paper
• Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia.

  1998cited by this paper
• Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

  1998cited by this paper
• Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.

  1998cited by this paper
• Recognizing death: the phagocytosis of apoptotic cells.

  1998cited by this paper
• Apoptosis of malignant human B cells by ligation of CD20 with monoclonal antibodies.

  1998cited by this paper
• Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2*

  1998cited by this paper
• Apoptosis-associated gene expression in the corpus luteum of the rat.

  1998cited by this paper
• Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells.

  1998cited by this paper
• Chlorambucil in Indolent Chronic Lymphocytic Leukemia

  1998influential reference
• Apoptosis: Phagocytic docking without shocking

  1998cited by this paper
• Chronic Lymphocytic Leukemic B Cells But Not Normal B Cells Are Rescued From Apoptosis by Contact With Normal Bone Marrow Stromal Cells

  1998cited by this paper
• Chronic Lymphocytic Leukemia B Cells Are Resistant to the Apoptotic Effects of Transforming Growth Factor-β

  1997cited by this paper
• CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.

  1997cited by this paper
• Role of the CD40 and CD95 (APO‐1/Fas) antigens in the apoptosis of human B‐cell malignancies

  1997cited by this paper
• HLA class II-mediated death is induced via Fas/Fas ligand interactions in human splenic B lymphocytes.

  1997cited by this paper
• Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells.

  1997cited by this paper
• Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells.

  1997cited by this paper
• Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes.

  1997cited by this paper
• Recognition and phagocytosis of cells undergoing apoptosis.

  1997cited by this paper
• Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

  1997cited by this paper
• Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

  1997cited by this paper
• Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta.

  1997cited by this paper
• Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia.

  1996cited by this paper
• Molecular thanatopsis: a discourse on the BCL2 family and cell death.

  1996cited by this paper
• National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment.

  1996cited by this paper
• Revised guidelines for diagnosis and treatment of CLL

  1996cited by this paper
• Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

  1996cited by this paper
• Adenovirus vector infection of chronic lymphocytic leukemia B cells.

  1996cited by this paper
• Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.

  1996cited by this paper
• BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases.

  1996cited by this paper
• Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX.

  1996cited by this paper
• Integrin-associated Protein Is a Receptor for the C-terminal Domain of Thrombospondin (*)

  1996cited by this paper
• B cell antigen receptor-mediated apoptosis. Importance of accessory molecules CD19 and CD22, and of surface IgM cross-linking.

  1995cited by this paper
• The two CD23 isoforms display differential regulation in chronic lymphocytic leukaemia

  1995cited by this paper
• Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis.

  1994cited by this paper
• Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine.

  1993cited by this paper
• Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding

  1993cited by this paper
• bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

  1993cited by this paper
• Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-β-D-arabinosyl-2-fluoroadenine

  1993cited by this paper
• bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia.

  1993cited by this paper
• Interleukin‐4 inhibits apoptotic cell death and loss of the bcl‐2 protein in B‐chronic lymphocytic leukaemia cells in vitro

  1993cited by this paper
• Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst

  1993cited by this paper
• Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

  1992cited by this paper
• Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression

  1992cited by this paper
• CD23 antigen regulation and signaling in chronic lymphocytic leukemia.

  1992cited by this paper

• CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies

  2026cites this paper
• Novel immunotherapy for gastric cancer: targeting the CD47–SIRPα axis

  2025cites this paper
• Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4+ T cells during blood-stage Plasmodium infection

  2025cites this paper
• Engineering TME-activated CD47-specific CAR macrophage via Arg1 promoter for safe and effective solid tumor immunotherapy

  2025cites this paper
• CD47 blockade enhances cisplatin sensitivity by inhibiting DNA repair gene expression.

  2025cites this paper
• Application of Biomimetic SPIONs in Targeted Lung Cancer Therapy: Cell-Membrane Camouflage Technology and Lung Retention Enhancement Strategies

  2025cites this paper
• The anti‐CD47 antibody magrolimab with obinutuzumab and venetoclax in relapsed or refractory indolent B‐cell lymphomas

  2025cites this paper
• A novel anti-CD47 antibody with therapeutic potential for NK/T-cell lymphoma

  2024cites this paper
• The potential of bacterial anti-phagocytic proteins in suppressing the clearance of extracellular vesicles mediated by host phagocytosis

  2024cites this paper
• Tumor Cell Survival Factors and Angiogenesis in Chronic Lymphocytic Leukemia: How Hot Is the Link?

  2024cites this paper
• A Novel Anti-CD47 Nanobody Tetramer for Cancer Therapy

  2024cites this paper
• Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity

  2024cites this paper
• Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells

  2024cites this paper
• Role of glutaminyl-peptide cyclo-transferase-like protein (QPCTL) in cancer: From molecular mechanisms to immunotherapy.

  2024cites this paper
• The application of antibody-based agents in cancer therapy based on their mechanisms of action

  2024cites this paper
• CD47: The Next Frontier in Immune Checkpoint Blockade for Non-Small Cell Lung Cancer

  2023cites this paper
• Deciphering the role of CD47 in cancer immunotherapy

  2023cites this paper
• G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy

  2023influential citation
• Emerging phagocytosis checkpoints in cancer immunotherapy

  2023influential citation
• MiR-133a/CD47 axis is a novel prognostic biomarker to promote triple negative breast cancer progression.

  2023cites this paper
• The Role of the Microenvironment and Cell Adhesion Molecules in Chronic Lymphocytic Leukemia

  2023cites this paper
• Potentiating antibody-dependent killing of cancers with CAR T cells secreting CD47-SIRPα checkpoint blocker.

  2023cites this paper
• Role of the tumor microenvironment in CLL pathogenesis.

  2023cites this paper
• Targeting CD47-SIRPα axis for Hodgkin and non-Hodgkin lymphoma immunotherapy

  2023cites this paper
• LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

  2023cites this paper
• Blocking CD47-SIRPα Signal Axis as Promising Immunotherapy in Ovarian Cancer

  2023cites this paper
• Functions of glutaminyl cyclase and its isoform in diseases

  2023cites this paper
• The Anticancer Effect of Phytochemicals and Potential of Breynia cernua: An overview

  2022cites this paper
• Targeting CD47 as a Novel Immunotherapy for Breast Cancer

  2022cites this paper
• Recent Advances of Tumor Therapy Based on the CD47-SIRPα Axis.

  2022cites this paper
• GPR183 mediates the capacity of the novel CD47-CD19 bispecific antibody TG-1801 to heighten ublituximab-umbralisib (U2) anti-lymphoma activity

  2022influential citation
• CD47 as a promising therapeutic target in oncology

  2022cites this paper
• αvβ3 Integrin Expression and Mitogenic Effects by Thyroid Hormones in Chronic Lymphocytic Leukemia

  2021cites this paper
• Prospects of antibodies targeting CD47 or CD24 in the treatment of glioblastoma

  2021cites this paper
• CD47 (Cluster of Differentiation 47).

  2021cites this paper
• An antitumor peptide RS17‐targeted CD47, design, synthesis, and antitumor activity

  2021cites this paper
• CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

  2021cites this paper
• Regulation and function of angiogenic factors in chronic lymphocytic leukemia

  2021cites this paper
• Nuclear αvβ3 integrin expression, post translational modifications and regulation in hematological malignancies

  2021cites this paper
• Targeting CD47 Inhibits Tumor Development and Increases Phagocytosis in Oral Squamous Cell Carcinoma.

  2020cites this paper
• Preclinical and Clinical Development of Therapeutic Antibodies Targeting Functions of CD47 in the Tumor Microenvironment.

  2020cites this paper
• The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a

  2020cites this paper
• CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions

  2020influential citation
• Thrombospondin in Tumor Microenvironment.

  2020cites this paper
• CD47: the next checkpoint target for cancer immunotherapy.

  2020cites this paper
• Tumor Microenvironment: Extracellular Matrix Components – Part B

  2020cites this paper
• Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

  2020cites this paper
• Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

  2020cites this paper
• CD47-SIRPα Axis as a Biomarker and Therapeutic Target in Cancer: Current Perspectives and Future Challenges in Nonsmall Cell Lung Cancer

  2020cites this paper
• Peptide analogues PKHB1 and 4N1K induce cell death through CD47‐independent mechanisms

  2020cites this paper
• Role of Non-Coding RNAs in the Development of Targeted Therapy and Immunotherapy Approaches for Chronic Lymphocytic Leukemia

  2020cites this paper
• Functions of Immune Checkpoint Molecules Beyond Immune Evasion.

  2020cites this paper
• Irradiation or temozolomide chemotherapy enhances anti-CD47 treatment of glioblastoma

  2019cites this paper
• Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells.

  2019cites this paper
• Effet de l'inhibition par ARN interférence de la thrombospondine-1 sur la potentialisation de la réponse immune dans un contexte tumoral

  2019cites this paper
• PKHB1 Tumor Cell Lysate Induces Antitumor Immune System Stimulation and Tumor Regression in Syngeneic Mice with Tumoral T Lymphoblasts

  2019cites this paper
• Study of the immunogenicity of the cell death induced by the activation of CD47 in tumor cells

  2019cites this paper
• Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding

  2019cites this paper
• Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations.

  2019cites this paper
• Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1-derived peptides overcomes drug resistance.

  2019cites this paper
• CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

  2018cites this paper
• Targeting the CD47-SIRPα signaling axis: current studies on B-cell lymphoma immunotherapy

  2018cites this paper
• CD47 agonist peptide PKHB1 induces immunogenic cell death in T‐cell acute lymphoblastic leukemia cells

  2018cites this paper
• SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy.

  2018cites this paper
• CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis

  2018cites this paper
• Blocking "don't eat me" signal of CD47-SIRPα in hematological malignancies, an in-depth review.

  2018cites this paper
• Design Of Anti-CD47 Molecules Using In Silico Approaches

  2018cites this paper
• A novel fully human anti-CD47 antibody as a potential therapy for human neoplasms with good safety.

  2018cites this paper
• CD47-ligation induced cell death in T-acute lymphoblastic leukemia

  2018cites this paper
• CD47, a multi-facetted target for cancer immunotherapy

  2017influential citation
• The CD47‐SIRPα signaling axis as an innate immune checkpoint in cancer

  2017cites this paper
• Cancer immunotherapy targeting the CD47/SIRPα axis.

  2017cites this paper
• Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis

  2017cites this paper
• Tumor cell-associated immune checkpoint molecules - Drivers of malignancy and stemness.

  2017cites this paper
• Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

  2017cites this paper
• Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts.

  2016cites this paper
• Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

  2016cites this paper
• Targeting the Cancer Biomarker CD47: A Review on the Diverse Mechanisms of the CD47 Pathway in Cancer Treatment.

  2016cites this paper
• A fully human anti-CD47 blocking antibody with therapeutic potential for cancer

  2016cites this paper
• Expresión de TSP-1 en carcinoma de mama

  2016cites this paper
• CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans

  2015cites this paper
• CD47-retargeted oncolytic adenovirus armed with melanoma differentiation-associated gene-7/interleukin-24 suppresses in vivo leukemia cell growth

  2015cites this paper
• CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer

  2015cites this paper
• Thrombospondin-1 induces differential response in human corneal and conjunctival epithelial cells lines under in vitro inflammatory and apoptotic conditions.

  2015cites this paper
• Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential

  2015cites this paper
• Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms

  2015cites this paper
• Blockade of CD47‐mediated cathepsin S/protease‐activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma

  2014cites this paper
• CD 47 : A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease

  2014cites this paper
• Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells

  2014cites this paper
• Ligation of CD47 Induces G1 Arrest in EBV-transformed B Cells Through ROS Generation, p38 MAPK/JNK Activation, and Tap73 Upregulation

  2014cites this paper
• Thrombospondin-1 Signaling Mechanisms Regulating Pigment Epithelium-Derived Factor Expression and Lipolytic Activity in Prostate Cancer

  2014cites this paper
• Establishment of a Therapeutic Anti-Pan HLA-Class II Monoclonal Antibody That Directly Induces Lymphoma Cell Death via Large Pore Formation

  2014cites this paper
• Domain-Bearing Protein Tyrosine through Binding of CD47 to Src Homology 2 Tethering of Apoptotic Cells to Phagocytes

  2013cites this paper
• CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease

  2013cites this paper
• The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes.

  2013cites this paper
• Thrombospondin Reduce Inflammation Interactions between CD47 and

  2013cites this paper
• mechanism involving the generation of reactive oxygen species lymphoproliferative disorders is mediated in vitro by a caspase-independent Complement-mediated cell death induced by rituximab in B-cell

  2013cites this paper
• Procédé et composition pharmaceutique pour l'utilisation dans le traitement du cancer

  2013cites this paper
• Mécanismes de progression des carcinomes de la prostate et recherche de nouveaux facteurs pronostiques

  2013cites this paper
• Regulación de apoptosis por fas y factor de transcripción yin-yang - 1 (yy-1) en células mononucleares de sangre periférica y su correlación con desarrollo de disfunción orgánica múltiple en niños con sepsis

  2012cites this paper