Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Neuron

• Publication date

  1993-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0896-6273(93)90163-LPMID 8476611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The regulation of prodynorphin gene expression in cultured spinal cord cells: involvement of second messengers.

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  1997cites this paper
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  1996cites this paper
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