Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of Clinical Investigation

• Publication date

  1997-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1172/JCI119255PMID 9062348PMCID PMC507898
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
• [Biology of mast cells ad basophils].

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  1996cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994influential reference
• Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule.

  1994cited by this paper
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  1993cited by this paper
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  1993influential reference
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  1993cited by this paper
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  1992cited by this paper
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  1991influential reference
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  1991cited by this paper
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  1991cited by this paper
• Control of in vivo IgE production in the mouse by interleukin 4.

  1989cited by this paper
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  1989influential reference
• Pulmonary responses to bronchoconstrictor agonists in the mouse.

  1988cited by this paper
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  1987cited by this paper
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  1987cited by this paper
• Immune response potential of mast cell-deficient W/Wv mice.

  1986cited by this paper
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  1984cited by this paper
• Immunoglobulin class switching.

  1984influential reference
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  1982cited by this paper
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  1980influential reference
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  1978cited by this paper
• Antigen and antibody detection by in vivo methods; a reevaluation of passive cutaneous anaphylactic reactions.

  1977cited by this paper
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  1970cited by this paper
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  1963cited by this paper

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