Mechanisms of absorption and elimination of drugs administered by inhalation.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Therapeutic delivery

• Publication date

  2013-08-07

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.4155/tde.13.67PMID 23919477
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nanoparticle geometry and surface orientation influence mode of cellular uptake.

  2013cited by this paper
• Pulmonary surfactants and their role in pathophysiology of lung disorders.

  2013cited by this paper
• In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice.

  2013cited by this paper
• Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: a study in ex vivo lung models using chemical inhibition and genetic knockout.

  2013cited by this paper
• Nanoparticle diffusion in respiratory mucus from humans without lung disease.

  2013cited by this paper
• Inhaled biopharmaceutical drug development: nonclinical considerations and case studies

  2013cited by this paper
• Comparison of two in vitro systems to assess cellular effects of nanoparticles-containing aerosols

  2013cited by this paper
• Microencapsulated chitosan nanoparticles for pulmonary protein delivery: in vivo evaluation of insulin-loaded formulations.

  2012cited by this paper
• Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis.

  2012cited by this paper
• Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer.

  2012cited by this paper
• Organic cation transporters in the blood-air barrier: expression and implications for pulmonary drug delivery.

  2012cited by this paper
• Building and maintaining the epithelium of the lung.

  2012cited by this paper
• Evaluation of Differentiated Human Bronchial Epithelial Cell Culture Systems for Asthma Research

  2012cited by this paper
• OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

  2012cited by this paper
• Claudins and alveolar epithelial barrier function in the lung

  2012cited by this paper
• Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study.

  2012cited by this paper
• The Effects of Excipients and Particle Engineering on the Biophysical Stability and Aerosol Performance of Parathyroid Hormone (1-34) Prepared as a Dry Powder for Inhalation

  2011cited by this paper
• Pulmonary Drug Metabolism, Clearance, and Absorption

  2011cited by this paper
• Drug Class Review: Controller Medications for Asthma

  2011cited by this paper
• Doxorubicin-conjugated quantum dots to target alveolar macrophages and inflammation.

  2011cited by this paper
• Xenobiotic metabolism and disposition in human lung: transcript profiling in non-tumoral and tumoral tissues.

  2011cited by this paper
• Spatial expression and functionality of drug transporters in the intact lung: objectives for further research.

  2011cited by this paper
• Pulmonary delivery of therapeutic compounds for treating CNS disorders.

  2011cited by this paper
• The Effect of Liposome Encapsulation on the Pharmacokinetics of Recombinant Secretory Leukocyte Protease Inhibitor (rSLPI) Therapy after Local Delivery to a Guinea Pig Asthma Model

  2011cited by this paper
• Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances.

  2011cited by this paper
• Challenges in inhaled product development and opportunities for open innovation.

  2011cited by this paper
• Toward managing chronic rejection after lung transplant: the fate and effects of inhaled cyclosporine in a complex environment.

  2011cited by this paper
• The Particle has Landed—Characterizing the Fate of Inhaled Pharmaceuticals

  2010cited by this paper
• Pulmonary Formulations: What Remains to be Done?

  2010cited by this paper
• Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs?

  2010cited by this paper
• Aerosol Gemcitabine: Preclinical Safety and In Vivo Antitumor Activity in Osteosarcoma-Bearing Dogs

  2010cited by this paper
• Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.

  2010cited by this paper
• Drug Delivery to the Lung: Permeability and Physicochemical Characteristics of Drugs as the Basis for a Pulmonary Biopharmaceutical ClassificationSystem (pBCS)

  2010cited by this paper
• Inhaled Voriconazole for Prevention of Invasive Pulmonary Aspergillosis

  2009cited by this paper
• Aerosol Delivery of Liposomal Formulated Paclitaxel and Vitamin E Analog Reduces Murine Mammary Tumor Burden and Metastases

  2009cited by this paper
• Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs

  2009cited by this paper
• RT‐PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models

  2009cited by this paper
• RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models.

  2009cited by this paper
• Vesicle Formation and Endocytosis: Function, Machinery, Mechanisms, and Modeling

  2009cited by this paper
• Inhaled therapeutics for prevention and treatment of pneumonia

  2009cited by this paper
• Tight junctions, but not too tight: fine control of lung permeability by claudins.

  2009cited by this paper
• Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery.

  2009cited by this paper
• Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit*

  2008cited by this paper
• Administration of antibiotics via the respiratory tract as monotherapy for pneumonia

  2008cited by this paper
• Acute passive cigarette smoke exposure and inhaled human insulin (Exubera) pharmacokinetics.

  2008cited by this paper
• In vitro cell culture models for the assessment of pulmonary drug disposition.

  2008cited by this paper
• The role of inhaled insulin in the treatment of type 2 diabetes.

  2008cited by this paper
• In vitro cell culture models for the assessment of pulmonary drug disposition

  2008cited by this paper
• Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: a prospective study.

  2008cited by this paper
• Solid lipid nanoparticles for pulmonary delivery of insulin.

  2008cited by this paper
• Feasibility and Safety of Targeted Cisplatin Delivery to a Select Lung Lobe in Dogs via the AeroProbe® Intracorporeal Nebulization Catheter

  2008cited by this paper
• Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells

  2008cited by this paper
• Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia.

  2008cited by this paper
• A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma.

  2008cited by this paper
• Cospray dried antibiotics for dry powder lung delivery.

  2008cited by this paper
• Role of Cilia, Mucus, and Airway Surface Liquid in Mucociliary Dysfunction: Lessons from Mouse Models

  2008cited by this paper
• Efflux Transporter Expression and Acetaminophen Metabolite Excretion Are Altered in Rodent Models of Nonalcoholic Fatty Liver Disease

  2007cited by this paper
• A Comparison of the Expression and Metabolizing Activities of Phase I and II Enzymes in Freshly Isolated Human Lung Parenchymal Cells and Cryopreserved Human Hepatocytes

  2007cited by this paper
• Salvage treatment of pneumonia and initial treatment of tracheobronchitis caused by multidrug-resistant Gram-negative bacilli with inhaled polymyxin B.

  2007cited by this paper
• Mucociliary clearance – a critical upper airway host defense mechanism and methods of assessment

  2007cited by this paper
• Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway.

  2007cited by this paper
• P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers

  2007cited by this paper
• Inhalable microparticles containing large payload of anti-tuberculosis drugs.

  2007cited by this paper
• Aerosolized Ceftazidime Prophylaxis against Ventilator-Associated Pneumonia in High-Risk Trauma Patients: Results of A Double-Blind Randomized Study

  2007cited by this paper
• Inhaled Large Porous Particles of Capreomycin for Treatment of Tuberculosis in a Guinea Pig Model

  2007cited by this paper
• Strategies for aerosol therapy ofα1-antitrypsin deficiency by the aerosol route

  2007cited by this paper
• Inhaling medicines: delivering drugs to the body through the lungs

  2007cited by this paper
• Expression of Xenobiotic Metabolizing Enzymes in Different Lung Compartments of Smokers and Nonsmokers

  2006cited by this paper
• Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers.

  2006cited by this paper
• In vitro study of the pulmonary translocation of nanoparticles: a preliminary study.

  2006cited by this paper
• Pharmacokinetics of 5-fluorouracil in the hamster following inhalation delivery of lipid-coated nanoparticles.

  2006cited by this paper
• Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig.

  2006cited by this paper
• Ciliary Function and the Role of Cilia in Clearance

  2006cited by this paper
• In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery.

  2006cited by this paper
• A three-dimensional cellular model of the human respiratory tract to study the interaction with particles.

  2005cited by this paper
• Correlation of in vitro cytotoxicity with paracellular permeability in Caco-2 cells.

  2005cited by this paper
• Human respiratory epithelial cell culture for drug delivery applications.

  2005cited by this paper
• Cell Culture Models of the Respiratory Tract Relevant to Pulmonary Drug Delivery

  2005cited by this paper
• Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosis

  2005cited by this paper
• Effect of Aerosolized Colistin on Multidrug-Resistant Pseudomonas aeruginosa in Bronchial Secretions of Patients without Cystic Fibrosis

  2005cited by this paper
• Serum biomarkers in Acute Respiratory Distress Syndrome an ailing prognosticator

  2005cited by this paper
• Pulmonary delivery of TH9507, a growth hormone releasing factor analogue, in the dog.

  2004cited by this paper
• Absorption enhancers in pulmonary protein delivery.

  2004cited by this paper
• The lungs as a portal of entry for systemic drug delivery.

  2004cited by this paper
• The tight junction: a multifunctional complex.

  2004cited by this paper
• Caveolin, Caveolae, and Endothelial Cell Function

  2003cited by this paper
• Pharmacokinetics of inhaled drugs.

  2003cited by this paper
• Alveolar macrophages: wielding the double-edged sword of inflammation.

  2003cited by this paper
• Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3.

  2003cited by this paper
• Direct lung delivery of para-aminosalicylic acid by aerosol particles.

  2003cited by this paper
• Targeting caveolae for vesicular drug transport.

  2003cited by this paper
• Poly (DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis.

  2003cited by this paper
• Impact of Drug Transporter Studies on Drug Discovery and Development

  2003cited by this paper
• 16HBE14o- Human Bronchial Epithelial Cell Layers Express P-Glycoprotein, Lung Resistance-Related Protein, and Caveolin-1

  2003cited by this paper
• Drug Absorption from the Isolated Perfused Rat Lung–Correlations with Drug Physicochemical Properties and Epithelial Permeability

  2003cited by this paper
• Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure-absorption relationships and physicochemical profiling of inhaled drugs.

  2003cited by this paper
• Nebulized amphotericin B concentration and distribution in the respiratory tract of lungtransplanted patients

  2003cited by this paper
• Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications.

  2003cited by this paper
• Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).

  2003cited by this paper
• Protein transport across the lung epithelial barrier.

  2003cited by this paper

• Impact of Hydrophobic, Hydrophilic, and Mucus-Binding Motifs on the Therapeutic Potential of Ceftazidime Analogs for Pulmonary Administration

  2025cites this paper
• Pharmacokinetic Analysis of Compounds Instilled into the Mouse Lung: Study with In Vivo Electron Spin Resonance Spectroscopy and Nitroxyl Spin Probes as Model Drugs.

  2025cites this paper
• Inflammatory lung diseases: a clinical and scientific review of the latest advances and challenges

  2025cites this paper
• Barriers that Inhaled Particles Encounter

  2024cites this paper
• Nanocrystal Agglomerates of Curcumin Prepared by Electrospray Drying as an Excipient-Free Dry Powder for Inhalation

  2024cites this paper
• Herbal Nanoformulations for Diabetes: Mechanisms, Formulations, and Clinical Impact.

  2024cites this paper
• Tunable rigidity of PLGA shell-lipid core nanoparticles for enhanced pulmonary siRNA delivery in 2D and 3D lung cancer cell models.

  2024cites this paper
• A 3D Model of the Human Lung Airway for Evaluating Permeability of Inhaled Drugs.

  2024cites this paper
• Impact of protein aggregation on the immunogenicity of a human monoclonal antibody following pulmonary administration in mice.

  2024cites this paper
• Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

  2023cites this paper
• Development of a new inhaled swellable microsphere system for the dual delivery of naringenin-loaded solid lipid nanoparticles and doxofylline for the treatment of asthma.

  2023cites this paper
• Preparation and evaluation of preventive effects of inhalational and intraperitoneal injection of Myrtenol loaded nano-niosomes on lung ischemia-reperfusion injury in rats.

  2023cites this paper
• Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis

  2023cites this paper
• Recent Advances in the Polish Research on Polysaccharide-Based Nanoparticles in the Context of Various Administration Routes

  2023cites this paper
• A Systematic Review of Clinical Pharmacokinetics of Inhaled Antiviral

  2023cites this paper
• Protein Aggregates in Inhaled Biologics: Challenges and Considerations

  2023cites this paper
• Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

  2022cites this paper
• Affinity of Compounds for Phosphatydylcholine-Based Immobilized Artificial Membrane—A Measure of Their Bioconcentration in Aquatic Organisms

  2022cites this paper
• Alternative Methods for Pulmonary-Administered Drugs Metabolism: a Breath of Change.

  2022cites this paper
• Progress in the Application of Nano- and Micro-based Drug Delivery Systems in Pulmonary Drug Delivery

  2021cites this paper
• Aerosol-based Pulmonary Delivery of Therapeutic Molecules from Food Sources: Delivery Mechanism, Research Trends, and the Way Forward

  2021cites this paper
• Advanced Nanoparticle-Based Drug Delivery Systems and Their Cellular Evaluation for Non-Small Cell Lung Cancer Treatment

  2021cites this paper
• Building three-dimensional lung models for studying pharmacokinetics of inhaled drugs.

  2020cites this paper
• LPS-induced inflammation delays the transportation of ASP+ due to down-regulation of OCTN1/2 in alveolar epithelial cells

  2020cites this paper
• Strategies for pulmonary delivery of drugs

  2020cites this paper
• Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosis

  2020cites this paper
• Effects of a novel roflumilast and formoterol fumarate dry powder inhaler formulation in experimental allergic asthma.

  2020cites this paper
• Non-invasive strategies for protein drug delivery: Oral, transdermal, and pulmonary

  2020cites this paper
• Pulmonary drug delivery-Determining attributes

  2020cites this paper
• Advances in Pulmonary Nanomedicine for Therapeutic Management of Respiratory Diseases

  2020cites this paper
• Drug Elimination

  2019cites this paper
• Bismuth Oxide Nanoparticles in Drug Delivery Systems

  2019cites this paper
• Computational intelligence for prediction of biological effects of drugs absorption in lungs

  2019cites this paper
• Enhancing Stability of Exenatide-Containing Pressurized Metered-Dose Inhaler Via Reverse Microemulsion System

  2018cites this paper
• Pharmacokinetics and pharmacodynamics of high doses of inhaled dry powder drugs

  2018cites this paper
• In vitro/in vivo investigation on the potential of Pluronic® mixed micelles for pulmonary drug delivery

  2018cites this paper
• SHetA2 Dry Powder Aerosols for Tuberculosis: Formulation, Design, and Optimization Using Quality by Design.

  2018cites this paper
• Formulation and evaluation of carrier-free dry powder inhaler containing sildenafil

  2018cites this paper
• Polymeric drug delivery micelle-like nanocarriers for pulmonary administration of beclomethasone dipropionate.

  2017cites this paper
• Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs.

  2017cites this paper
• Development of fine solid-crystal suspension with enhanced solubility, stability, and aerosolization performance for dry powder inhalation.

  2017cites this paper
• PRESENTAZIONI ORALI A bald mutant of Streptomyces coelicolor overproducing undecylprodigiosin and streptorubin B

  2017cites this paper
• Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

  2017cites this paper
• Cell-based in vitro models for pulmonary permeability studies

  2016cites this paper
• Sustained Pulmonary Delivery of a Water-Soluble Antibiotic Without Encapsulating Carriers

  2016cites this paper
• Enhanced pulmonary delivery of fluticasone propionate in rodents by mucus-penetrating nanoparticles.

  2016cites this paper
• Generation of tailored aerosols for inhalative drug delivery employing recent vibrating-mesh nebulizer systems.

  2015cites this paper
• Inhalation drug delivery devices: technology update

  2015cites this paper
• Lung Anatomy and Physiology and Their Implications for Pulmonary Drug Delivery

  2015cites this paper
• Pharmacokinetics of Inhaled Rifampicin Porous Particles for Tuberculosis Treatment: Insight into Rifampicin Absorption from the Lungs of Guinea Pigs.

  2015cites this paper
• Alternate Routes of Administration of Antidepressant and Antipsychotic Medications

  2015cites this paper
• Drug-targeting methodologies with applications: A review.

  2014cites this paper
• Pulmonary multifunctional nano-oncological modules for lung cancer treatment and prevention.

  2014cites this paper
• Pulmonary Drugs and Genes Delivery Systems for Lung Disease Treatment

  2014cites this paper
• Pulmonary drug delivery.

  2013cites this paper