The FDG lumped constant in normal human brain.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Nuclear Medicine

• Publication date

  2002-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 12215553
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Kinetic characterization of hexokinase isoenzymes from glioma cells: implications for FDG imaging of human brain tumors.

  2001cited by this paper
• The 18F-fluorodeoxyglucose Lumped Constant Determined in Human Brain from Extraction Fractions of 18F-fluorodeoxyglucose and Glucose

  2001cited by this paper
• Myocardial glucose uptake measured with fluorodeoxyglucose: a proposed method to account for variable lumped constants.

  1999cited by this paper
• Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-11]glucose and FDG: analysis of the FDG lumped constant.

  1998cited by this paper
• Calculation of the FDG Lumped Constant by Simultaneous Measurements of Global Glucose and FDG Metabolism in Humans

  1998cited by this paper
• Physiologic smoothing of blood time-activity curves for PET data analysis.

  1997cited by this paper
• Investigation of the performance of the General Electric Advance positron emission tomograph in 3D mode

  1995cited by this paper
• Investigation of the count rate performance of the General Electric Advance positron emission tomograph

  1994cited by this paper
• Performance characteristics of a whole-body PET scanner.

  1994cited by this paper
• Regional cerebral oxidative and total glucose consumption during rest and activation studied with positron emission tomography.

  1994cited by this paper
• MRI‐PET Registration with Automated Algorithm

  1993influential reference
• Improved synthesis of 1-[11C]D-glucose.

  1993cited by this paper
• High-speed automated discrete blood sampling for positron emission tomography.

  1993cited by this paper
• Estimation of Local Cerebral Glucose Utilization by Positron Emission Tomography: Comparison of [18F]2-Fluoro-2-Deoxy-D-Glucose and [18F]2-Fluoro-2-Deoxy-D-Mannose in Patients with Focal Brain Lesions

  1991cited by this paper
• Diminished Glucose Transport in Alzheimer's Disease: Dynamic PET Studies

  1991cited by this paper
• Positron Emission Tomographic Measurements of Cerebral Glucose Utilization Using [1-11C]D-Glucose

  1990cited by this paper
• Michaelis-Menten Constraints Improved Cerebral Glucose Metabolism and Regional Lumped Constant Measurements with [18F]Fluorodeoxyglucose

  1990cited by this paper
• Glycolysis-Induced Discordance between Glucose Metabolic Rates Measured with Radiolabeled Fluorodeoxyglucose and Glucose

  1989cited by this paper
• The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases.

  1988cited by this paper
• Measurement of Glucose Utilisation with [18F]2-Fluoro-2-Deoxy-D-Glucose: A Comparison of Different Analytical Methods

  1987cited by this paper
• Cerebral Glucose Utilization: Comparison of [14C]Deoxyglucose and [6‐14C]Glucose Quantitative Autoradiography

  1987cited by this paper
• Human Cerebral Glucose Metabolism Determined by Positron Emission Tomography: A Revisit

  1987cited by this paper
• Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.

  1986cited by this paper
• Tomographic Mapping of Kinetic Rate Constants in the Fluorodeoxyglucose Model Using Dynamic Positron Emission Tomography

  1986cited by this paper
• Effect of Vascular Activity in the Determination of Rate Constants for the Uptake of 18F-Labeled 2-Fluoro-2-Deoxy-D-Glucose: Error Analysis and Normal Values in Older Subjects

  1986cited by this paper
• Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]Deoxyglucose

  1985cited by this paper
• Comparative Regional Analysis of 2-Fluorodeoxyglucose and Methylglucose Uptake in Brain of Four Stroke Patients. With Special Reference to the Regional Estimation of the Lumped Constant

  1985cited by this paper
• Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [18F]-2-Fluoro-2-Deoxy-D-Glucose

  1984cited by this paper
• Kinetics of Transport and Phosphorylation of 2‐Fluoro‐2‐Deoxy‐d‐Glucose in Rat Brain

  1983cited by this paper
• Quantitation of regional cerebral glucose metabolism.

  1983influential reference
• Autoradiographic Determination of Regional Brain Glucose Content

  1983cited by this paper
• Noninvasive determination of local cerebral metabolic rate of glucose in man.

  1980cited by this paper
• Brain hexokinase, the prototype ambiquitous enzyme.

  1980cited by this paper
• Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids

  1980cited by this paper
• Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method

  1979cited by this paper
• THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

  1977influential reference

• Brain aerobic glycolysis is stable during adulthood: Direct evidence from cross-brain blood sampling in 239 healthy adults

  2026cites this paper
• Metformin-regulated glucose flux from the circulation to the intestinal lumen

  2025cites this paper
• Determination of unscaled blood input for human dynamic FDG brain PET

  2025cites this paper
• Non-invasive arterial input function estimation using an MRA atlas and machine learning

  2025cites this paper
• Optimal filtering strategies for task-specific functional PET imaging

  2024cites this paper
• Mapping 18F-FDG Kinetics Together with Patient-Specific Bootstrap Assessment of Uncertainties: An Illustration with Data from a PET/CT Scanner with a Long Axial Field of View

  2024cites this paper
• Automated extraction of the arterial input function from brain images for parametric PET studies

  2024cites this paper
• A short 18F-FDG imaging window triple injection neuroimaging protocol for parametric mapping in PET

  2024cites this paper
• Peripheral insulin resistance attenuates cerebral glucose metabolism and impairs working memory in healthy adults

  2024cites this paper
• A unified approach for identifying PET-based neuronal activation and molecular connectivity with the functional PET toolbox

  2024cites this paper
• SNMMI Procedure Standard/EANM Practice Guideline for Brain [18F]FDG PET Imaging, Version 2.0.

  2024cites this paper
• High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response

  2023influential citation
• Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research

  2023cites this paper
• Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study

  2023cites this paper
• Non-invasive assessment of stimulation-specific changes in cerebral glucose metabolism with functional PET

  2023influential citation
• A convolutional neural network-based system to estimate the arterial plasma radioactivity curve in 18F-FDG dynamic brain PET study

  2023cites this paper
• Comparison of cardiac image-derived input functions for quantitative whole body [18F]FDG imaging with arterial blood sampling

  2023cites this paper
• Principles of Tracer Kinetic Analysis in Oncology, Part I: Principles and Overview of Methodology

  2022cites this paper
• Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells

  2022cites this paper
• Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice.

  2022cites this paper
• Patient-adaptive Population-based Modeling of Arterial Input Functions

  2022cites this paper
• Task-evoked metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks

  2022cites this paper
• Lower brain glucose metabolism in normal ageing is predominantly frontal and temporal: A systematic review and pooled effect size and activation likelihood estimates meta‐analyses

  2022cites this paper
• Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI

  2022cites this paper
• Normal values for 18F-FDG uptake in organs and tissues measured by dynamic whole body multiparametric FDG PET in 126 patients

  2022cites this paper
• First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long axial FOV PET scanner in oncological patients

  2022cites this paper
• Communication consumes 35 times more energy than computation in the human cortex, but both costs are needed to predict synapse number

  2021cites this paper
• EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3

  2021cites this paper
• Neuro-Oncology Practice Clinical Debate: FDG PET to differentiate glioblastoma recurrence from treatment-related changes.

  2021cites this paper
• Cerebral cortical communication overshadows computational energy-use, but these combine to predict synapse number

  2021cites this paper
• Computation in the human cerebral cortex uses less than 0.2 watts yet this great expense is optimal when considering communication costs

  2020cites this paper
• FDG PET/CT of the non-malignant liver in an increasingly obese world population.

  2020cites this paper
• Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer’s disease

  2020cites this paper
• Data modeling and simulation

  2020cites this paper
• The role of endoplasmic reticulum in in vivo cancer FDG kinetics

  2019cites this paper
• Brain Glucose Metabolism: Integration of Energetics with Function.

  2019cites this paper
• Obligatory role of endoplasmic reticulum in brain FDG uptake

  2019cites this paper
• Relationship between regional hepatic glucose metabolism and regional distribution of hepatic fat

  2019cites this paper
• G6Pase location in the endoplasmic reticulum: Implications on compartmental analysis of FDG uptake in cancer cells

  2019cites this paper
• EANM / EANO / RANO practice guidelines / SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [ F-18 ] FDG

  2019cites this paper
• Intrahepatic fluorine-18-fluorodeoxyglucose kinetics measured by least squares nonlinear computer modelling and Gjedde–Patlak–Rutland graphical analysis

  2019cites this paper
• Diagnostic Efficacy of 18F-FDG PET/MRI in Peripheral Nerve Injury Models

  2019cites this paper
• Comparison of different quantification methods for 18F-fluorodeoxyglucose-positron emission tomography studies in rat brains

  2019cites this paper
• Analysis of continuous infusion functional PET (fPET) in the human brain

  2019cites this paper
• Does 2-FDG PET Accurately Reflect Quantitative In Vivo Glucose Utilization?

  2019cites this paper
• FDG uptake tracks the oxidative damage in diabetic skeletal muscle: An experimental study

  2019cites this paper
• Brain Blood Flow and Metabolism: Variable Relationships in Altered Metabolic States

  2019cites this paper
• Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood

  2018cites this paper
• In vivo simultaneous imaging with 99mTc and 18F using a Compton camera

  2018cites this paper
• Effect of starvation on brain glucose metabolism and 18F-2-fluoro-2-deoxyglucose uptake: an experimental in-vivo and ex-vivo study

  2018cites this paper
• Hepato-splenic axis: hepatic and splenic metabolic activities are linked.

  2018cites this paper
• Interindividual and regional relationship between cerebral blood flow and glucose metabolism in the resting brain.

  2018influential citation
• A nonhuman primate model of early Alzheimer’s disease pathologic change: Implications for disease pathogenesis

  2018cites this paper
• Joint EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0

  2018cites this paper
• Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain

  2018cites this paper
• Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial

  2018cites this paper
• Overview of Positron-Emission Tomography Tracers for Metabolic Imaging

  2018cites this paper
• Loss of Brain Aerobic Glycolysis in Normal Human Aging.

  2017cites this paper
• Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study

  2017influential citation
• Estimation of an image derived input function with MR-defined carotid arteries in FDG-PET human studies using a novel partial volume correction method

  2017cites this paper
• Comparison of analytical methods of brain [18F]FDG-PET after severe traumatic brain injury.

  2017cites this paper
• Simultaneous EEG–PET–fMRI measurements in disorders of consciousness: an exploratory study on diagnosis and prognosis

  2017cites this paper
• Spatial distribution of resting‐state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging

  2017cites this paper
• A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study

  2017influential citation
• Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG

  2016cites this paper
• Whole-body dynamic imaging with continuous bed motion PET/CT

  2016cites this paper
• Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: do cognitively-normal older adults have a particular metabolic phenotype?

  2016cites this paper
• Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET

  2015cites this paper
• Calf muscle activation strategies in healthy and injured achilles tendon conditions

  2015cites this paper
• Quantitative characterisation of solid tumours by 18F-FDG PET. What's in a number?

  2015cites this paper
• Influence of P-Glycoprotein Inhibition or Deficiency at the Blood–Brain Barrier on 18F-2-Fluoro-2-Deoxy-d-glucose (18F-FDG) Brain Kinetics

  2015cites this paper
• Jenni Kulmala Calf Muscle Activation Strategies in Healthy and Injured Achilles Tendon Conditions 222 STUDIES IN SPORT , PHYSICAL EDUCATION AND HEALTH

  2015cites this paper
• Lower Brain 18F-Fluorodeoxyglucose Uptake But Normal 11C-Acetoacetate Metabolism in Mild Alzheimer's Disease Dementia

  2014cites this paper
• Brain glucose and acetoacetate metabolism: a comparison of young and older adults.

  2014cites this paper
• An Analysis of Whole Body Tracer Kinetics in Dynamic PET Studies With Application to Image-Based Blood Input Function Extraction

  2014cites this paper
• VOXEL-LEVEL MAPPING OF TRACER KINETICS IN PET STUDIES: A STATISTICAL APPROACH EMPHASIZING TISSUE LIFE TABLES.

  2014cites this paper
• Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults.

  2014cites this paper
• Dynamic functional imaging of brain glucose utilization using fPET-FDG

  2014influential citation
• Estimation de la fonction d’entrée en tomographie par émission de positons dynamique : application au fluorodesoxyglucose

  2013cites this paper
• Regional, kinetic [(18)F]FDG PET imaging of a unilateral Parkinsonian animal model.

  2013cites this paper
• Quantificatie van dynamische FDG PET bij patiënten met refractaire temporaalkwab epilepsie

  2013cites this paper
• On Glucose Metabolism in Patients with the m.3243A>G Mutation

  2013cites this paper
• Investigation of the Effects of Image Signal-to-Noise Ratio on TSPO PET Quantification of Neuroinflammation

  2013cites this paper
• Influence of the partial volume correction method on 18F-fluorodeoxyglucose brain kinetic modelling from dynamic PET images reconstructed with resolution model based OSEM

  2013cites this paper
• Brain metabolism in patients with hepatic encephalopathy studied by PET and MR.

  2013cites this paper
• Back to the future: the absolute quantification of cerebral metabolic rate of glucose

  2013cites this paper
• The Coupling of Cerebral Metabolic Rate of Glucose and Cerebral Blood Flow In Vivo

  2012cites this paper
• Dorsal Striatum and Its Limbic Connectivity Mediate Abnormal Anticipatory Reward Processing in Obesity

  2012cites this paper
• On the use of image derived input function for quantitative PET imaging with a simultaneous measuring MR-BrainPET

  2012influential citation
• Quantification in dynamic and small-animal positron emission tomography

  2011cites this paper
• A robust state-space kinetics-guided framework for dynamic PET image reconstruction

  2011cites this paper
• Brain fuel metabolism, aging, and Alzheimer's disease.

  2011cites this paper
• Quantitative Techniques in PET-CT Imaging

  2011cites this paper
• Kinetic Quantitation of Cerebral PET-FDG Studies Without Concurrent Blood Sampling: Statistical Recovery of the Arterial Input Function

  2010cites this paper
• Tracer Kinetic Modeling: Methodology and Applications

  2010cites this paper
• Volume-Normalized Uptake Rates with Robust Transportability from PET Dual-time and Patlak Analyses

  2010cites this paper
• F-FDG kinetics of brain structures: In vivo feasibility and preliminary results

  2009cites this paper
• EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2

  2009cites this paper
• Feasibility study of the non-invasive estimation of the b+ arterial input function for human PET imaging

  2009cites this paper
• Increased Cerebral Uptake of [18F]Fluoro-Deoxyglucose but not [1-14C]Glucose Early following Traumatic Brain Injury in Rats

  2009cites this paper