Mechanisms of gene silencing by double-stranded RNA

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature

• Publication date

  2004-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature02873PMID 15372041
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

  2004cited by this paper
• Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

  2004cited by this paper
• RISC assembly defects in the Drosophila RNAi mutant armitage.

  2004cited by this paper
• Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.

  2004cited by this paper
• The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification.

  2004cited by this paper
• The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

  2004cited by this paper
• Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

  2004cited by this paper
• Intensified Cloning Efforts Have Revealed Numer

  2004cited by this paper
• RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

  2004cited by this paper
• A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila.

  2004cited by this paper
• Argonaute2 Is the Catalytic Engine of Mammalian RNAi

  2004cited by this paper
• Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

  2004cited by this paper
• A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans

  2004cited by this paper
• Nuclear Export of MicroRNA Precursors

  2004cited by this paper
• Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways.

  2004cited by this paper
• Genetic and Functional Diversification of Small RNA Pathways in Plants

  2004cited by this paper
• RNA Silencing Genes Control de Novo DNA Methylation

  2004cited by this paper
• Identification of Virus-Encoded MicroRNAs

  2004cited by this paper
• RISC is a 5' phosphomonoester-producing RNA endonuclease.

  2004cited by this paper
• Spatially restricted microRNA directs leaf polarity through ARGONAUTE1

  2004cited by this paper
• Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

  2004cited by this paper
• RNA interference in protozoan parasites

  2004cited by this paper
• Nucleic acid 3′-end recognition by the Argonaute2 PAZ domain

  2004cited by this paper
• The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing.

  2004cited by this paper
• The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation.

  2004cited by this paper
• Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs.

  2004cited by this paper
• Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila.

  2003cited by this paper
• Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs.

  2003cited by this paper
• Functional siRNAs and miRNAs exhibit strand bias.

  2003cited by this paper
• A micrococcal nuclease homologue in RNAi effector complexes

  2003cited by this paper
• Recognition of small interfering RNA by a viral suppressor of RNA silencing

  2003cited by this paper
• The nuclear RNase III Drosha initiates microRNA processing

  2003cited by this paper
• Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation

  2003cited by this paper
• Reduced accumulation of specific microRNAs in colorectal neoplasia.

  2003cited by this paper
• Asymmetry in the Assembly of the RNAi Enzyme Complex

  2003cited by this paper
• ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

  2003cited by this paper
• The Arabidopsis heterochronic gene ZIPPY is an ARGONAUTE family member.

  2003cited by this paper
• Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

  2003cited by this paper
• Size selective recognition of siRNA by an RNA silencing suppressor.

  2003cited by this paper
• Human let-7 stem-loop precursors harbor features of RNase III cleavage products.

  2003cited by this paper
• siRNAs can function as miRNAs

  2003cited by this paper
• Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance.

  2003cited by this paper
• A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis.

  2003cited by this paper
• RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase.

  2003cited by this paper
• Nucleic Acid-Based Immune System: the Antiviral Potential of Mammalian RNA Silencing

  2003cited by this paper
• Identification of eight members of the Argonaute family in the human genome.

  2003cited by this paper
• R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

  2003cited by this paper
• Mutations in RNAi Rescue Aberrant Chemotaxis of ADAR Mutants

  2003cited by this paper
• siRNAs can function as miRNAs.

  2003cited by this paper
• Asymmetry in the assembly of the RNAi enzyme complex.

  2003cited by this paper
• Fragile X-related protein and VIG associate with the RNA interference machinery.

  2002cited by this paper
• Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

  2002cited by this paper
• The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.

  2002cited by this paper
• PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans.

  2002cited by this paper
• Induction and Suppression of RNA Silencing by an Animal Virus

  2002cited by this paper
• Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.

  2002cited by this paper
• MicroRNA maturation: stepwise processing and subcellular localization

  2002cited by this paper
• The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.

  2002cited by this paper
• RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs

  2002cited by this paper
• Ribonuclease activity and RNA binding of recombinant human Dicer

  2002cited by this paper
• ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

  2002cited by this paper
• Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1

  2002cited by this paper
• The genetics of RNA silencing.

  2002cited by this paper
• Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

  2002cited by this paper
• RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila.

  2002cited by this paper
• The role of RNA editing by ADARs in RNAi.

  2002cited by this paper
• miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.

  2002cited by this paper
• Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

  2002cited by this paper
• RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.

  2002cited by this paper
• A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.

  2002cited by this paper
• Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation.

  2002cited by this paper
• Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

  2002cited by this paper
• RNA silencing as a plant immune system against viruses.

  2001cited by this paper
• Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.

  2001cited by this paper
• RNA interference is mediated by 21- and 22-nucleotide RNAs.

  2001cited by this paper
• ATP requirements and small interfering RNA structure in the RNA interference pathway.

  2001cited by this paper
• Viral suppressors of RNA silencing.

  2001cited by this paper
• Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

  2001cited by this paper
• Role for a bidentate ribonuclease in the initiation step of RNA interference

  2001cited by this paper
• On the role of RNA amplification in dsRNA-triggered gene silencing.

  2001cited by this paper
• A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

  2001cited by this paper
• Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

  2001cited by this paper
• Gene silencing as an adaptive defence against viruses

  2001cited by this paper
• SDE3 encodes an RNA helicase required for post‐transcriptional gene silencing in Arabidopsis

  2001cited by this paper
• Role of short RNAs in gene silencing.

  2001cited by this paper
• EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.

  2000cited by this paper
• Erratum: EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans (Current Biology (2000) 10 (169-178))

  2000cited by this paper
• Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance.

  2000cited by this paper
• Variation in the reversibility of evolution

  2000cited by this paper
• AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.

  2000cited by this paper
• A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans.

  2000cited by this paper
• An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

  2000cited by this paper
• Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase

  1999cited by this paper
• The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation.

  1999cited by this paper
• Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

  1999cited by this paper
• Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase.

  1999cited by this paper
• AGO1 defines a novel locus of Arabidopsis controlling leaf development

  1998cited by this paper
• A model for RNA-mediated gene silencing in higher plants

  1998cited by this paper
• Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

  1998cited by this paper
• Structure and expression of hcr, a locus rearranged with c-myc in a woodchuck hepatocellular carcinoma.

  1989cited by this paper

• RIMap-RISC: a transcriptome-wide database of structurally modeled human microRNA interactions.

  2026cites this paper
• Spray-Applied RNA Interference Biopesticides: Mechanisms, Technological Advances, and Challenges Toward Sustainable Pest Management

  2026cites this paper
• Uncovering miRNA-Disease Associations Through Graph Based Neural Network Representations.

  2026cites this paper
• RNAi-Based Molecular Biopesticide: Inspired by Nature, Precision by Science, and Harmony to the Ecosystem.

  2026cites this paper
• Technology for Nucleic Acid Delivery in the treatment of Hematological malignancies.

  2026cites this paper
• Coding Transcript-Derived Small Interfering RNAs: Their Biogenesis and Molecular Function in Arabidopsis.

  2026cites this paper
• Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease.

  2026cites this paper
• Distinct Serum MicroRNA Signatures and mRNA Decay Pathway Dysregulation in NSAID-Exacerbated Chronic Urticaria

  2026cites this paper
• Antagonism in Orthotospoviruses Is Reflected in Plant Small RNA Profile

  2025cites this paper
• New Therapeutic Modalities in Prion Diseases.

  2025cites this paper
• RNA interference as a tool for functional genomics in parasitic helminths.

  2025cites this paper
• Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications

  2025cites this paper
• Unveiling the translational and therapeutic potential of small interfering RNA molecules in combating SARS-CoV-2: A review.

  2025cites this paper
• HARNESSING RNA-MEDIATED RESISTANCE TO COMBAT YELLOW VEIN MOSAIC VIRUS IN OKRA

  2025cites this paper
• miRNA expression based modulation: A new paradigm for the treatment of chronic myeloid leukemia.

  2025cites this paper
• Nanotechnological approaches in topical RNAi therapy for skin diseases

  2025cites this paper
• DNA Demethylase ROS1 Interferes with DNA Methylation and Activates Stress Response Genes in Plants Infected with Beet Severe Curly Top Virus

  2025cites this paper
• Insect Pest Control from Chemical to Biotechnological Approach: Constrains and Challenges

  2025cites this paper
• MicroRNA regulation in neural tube defects: Insights into pathogenesis and potential therapeutic targets.

  2025cites this paper
• Unveiling the behavior of cubic and reverse hexagonal liquid crystalline nanoparticles in cellular and skin delivery of glucocorticoid and small interfering RNA

  2025cites this paper
• Silencing of a chemosensory membrane protein gene, the odorant receptor co-receptor (Orco), induces a significant disruption in olfactory-driven behaviors of the pumpkin fruit fly, Bactrocera tau (Walker) (Diptera: Tephritidae).

  2025cites this paper
• Recent Advances and Emerging Applications of Small RNA Technologies in Plant Disease Resistance: A Narrative Review

  2025cites this paper
• Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration

  2025cites this paper
• C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer’s Disease

  2025cites this paper
• RNAi-mediated gene knockdown and anti-Vibrio parahaemolyticus effects in Penaeus vannamei using mPEG-PEI-c-SWNTs siRNA system

  2025cites this paper
• Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies

  2025cites this paper
• MicroRNA-Mediated Regulation of Vascular Endothelium: From Pro-Inflammation to Atherosclerosis

  2025cites this paper
• Chemical Modifications in Nucleic Acid Therapeutics.

  2025cites this paper
• Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations

  2025cites this paper
• Efficient Gene Knockdown in Adult Zebrafish Retina by Intravitreal Injection

  2025cites this paper
• Double-stranded RNA delivery through soaking stimulates antiviral responses in shrimp

  2025cites this paper
• Optimizing dsRNA sequences for RNAi in pest control and research with the dsRIP web platform

  2025cites this paper
• Nanotechnology-driven gene silencing: advancements in SIGS–dsRNA technology for sustainable disease management

  2025cites this paper
• AutoFE-Pointer: Auto-weighted feature extractor based on pointer network for DNA methylation prediction.

  2025cites this paper
• Predicting microRNAs and their Target Genes Involved in Sepsis Pathogenesis by using Bioinformatics Methods.

  2025cites this paper
• GalNac-siRNA conjugate delivery technology promotes the treatment of typical chronic liver diseases

  2025cites this paper
• Streamlining Bacterial Gene Regulation via Nucleic Acid Delivery with Gold Nanoclusters.

  2025cites this paper
• Building public trust and acceptance towards spray-on RNAi biopesticides: lessons from current ethical, legal and social discourses

  2025cites this paper
• Non-Viral RNA Therapies for Non-Small Cell Lung Cancer and Their Corresponding Clinical Trials.

  2025cites this paper
• Effect of protein binding on the twist-stretch coupling of double-stranded RNA.

  2025cites this paper
• FGFR3 signaling is essential for gastric cancer cell triggering the transition of BM-MSCs into tumor-associated MSCs.

  2025cites this paper
• Genetic Basis for Biotic Stress Resistance in Plants from Solanaceae Family: A Review

  2025cites this paper
• Graph Convolutional Network with Neural Collaborative Filtering for Predicting miRNA-Disease Association

  2025cites this paper
• Control of Fusarium graminearum Infection in Wheat by dsRNA-Based Spray-Induced Gene Silencing.

  2025cites this paper
• Evaluating the potential of RNA interference for control of striped cucumber beetle, Acalymma vittatum (Fabricius) (Coleoptera: Chrysomelidae).

  2025cites this paper
• An overview of strategies and challenges adopted to silence BCR-ABL gene by small interfering RNA.

  2025cites this paper
• DeepWalk-Based Graph Embeddings for miRNA–Disease Association Prediction Using Deep Neural Network

  2025cites this paper
• Non-transgenic RNAi strategies for sustainable plant viral disease control: a review

  2025cites this paper
• miR-92a-3p regulates egg fertilization through ribogenesis in the invasive fall armyworm Spodoptera frugiperda.

  2025cites this paper
• Optimizing siRNA Therapeutics Targeting HIF-1α: Computational Design, Screening, and Molecular Dynamics Simulation Studies.

  2025cites this paper
• Integrated Transcriptomics and Targeted Metabolomics Delineate the Mechanisms of MYMIV Resistance in Soybean Via Regulation of Isoflavonoid Biosynthesis, Hormone Signalling, and RNA Silencing Pathways

  2025cites this paper
• Doubling down on groundnut bud necrosis virus: combined dsRNAs targeting non-structural (NSs) and nucleocapsid (NP) genes confer superior resistance

  2025cites this paper
• Trans-Kingdom sRNA Silencing in Sclerotinia sclerotiorum for Crop Fungal Disease Management

  2025cites this paper
• The roles of subcellular Argonaute 2 in cardiovascular diseases

  2025cites this paper
• Microvesicle-Shuttled microRNA-130b Activates the Hepatic Inflammation by Inhibiting Glucocorticoid-Receptor-Mediated Immunosuppression in High-Fat Diet-Induced Obese Mice

  2024cites this paper
• Specific modulation of CRISPR transcriptional activators through RNA-sensing guide RNAs in mammalian cells and zebrafish embryos

  2024cites this paper
• Unveiling the challenges of short non-coding RNAs and their prospects in cancer therapy

  2024cites this paper
• Extracellular vesicles in malaria: Pathogenesis, diagnosis and therapy.

  2024cites this paper
• Opportunities for Riboswitch Inhibition by Targeting Co-Transcriptional RNA Folding Events

  2024cites this paper
• Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases.

  2024cites this paper
• Delivery of virus-specific dsRNA using a composite nanomaterial improves the protection of shrimp (Litopenaeus vannamei) against yellow head virus challenge

  2024cites this paper
• Beyond RNAi: How the Dicer protein modulates the antiviral innate immune response in mammalian cells

  2024cites this paper
• ML-Based RNA Secondary Structure Prediction Methods: A Survey

  2024cites this paper
• Structural stability-aware deep learning: advancing RNA secondary structure prediction

  2024cites this paper
• Deep dive into RNA: a systematic literature review on RNA structure prediction using machine learning methods

  2024cites this paper
• CRISPR-Cas13-mediated RNA editing in the silkworm Bombyx mori

  2024cites this paper
• Novel insights on the positive correlation between sense and antisense pairs on gene expression

  2024cites this paper
• HTFSMMA: Higher-Order Topological Guided Small Molecule–MicroRNA Associations Prediction

  2024cites this paper
• Tuning Ultrasensitivity in Genetic Logic Gates Using Antisense RNA Feedback

  2024cites this paper
• Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model

  2024cites this paper
• Insect immunity in the Anthropocene

  2024influential citation
• Predicting miRNA-drug interactions via dual-channel network based on TCN and BiLSTM

  2024cites this paper
• The Role of MicroRNAs in the Pathophysiology of Osteoarthritis

  2024cites this paper
• Temporal control of RNAi reveals both robust and labile feedback loops in the segmentation clock of the red flour beetle

  2024cites this paper
• Biochemical and nanotechnological approaches to combat phytoparasitic nematodes

  2024cites this paper
• Interferon-Regulated Expression of Cellular Splicing Factors Modulates Multiple Levels of HIV-1 Gene Expression and Replication

  2024cites this paper
• The crosstalk between miRNAs and signaling pathways in human cancers: Potential therapeutic implications.

  2024cites this paper
• Challenges of Robust RNAi-Mediated Gene Silencing in Aedes Mosquitoes

  2024cites this paper
• Assembling the RNA therapeutics toolbox

  2024cites this paper
• Therapeutic siRNA Loaded to RISC as Single and Double Strands Requires an Appropriate Quantitative Assay for RISC PK Assessment

  2024cites this paper
• Cre-Lox miRNA-delivery technology optimized for inducible microRNA and gene-silencing studies in zebrafish

  2024cites this paper
• Knockdown of orthotospovirus-derived silencing suppressor gene by plant-mediated RNAi approach induces viral resistance in tomato

  2024cites this paper
• Hairpin-RNA Spray Confers Resistance to Mungbean Yellow Mosaic India Virus in Mungbean

  2024cites this paper
• Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes

  2024cites this paper
• miR-144 affects the immune response and activation of inflammatory responses in Cynoglossus semilaevis by regulating the expression of CsMAPK6.

  2024cites this paper
• Structural insights into double-stranded RNA recognition and transport by SID-1

  2024cites this paper
• An overview of genetic manipulation tools in the studies of ciliates, with emphasis on gene knockout, knockdown, and overexpression

  2024cites this paper
• Lipid-Based Nanocarriers for Targeted Gene Delivery in Lung Cancer Therapy: Exploring a Novel Therapeutic Paradigm.

  2024cites this paper
• RNA-based therapies in hepatocellular carcinoma: state of the art and clinical perspectives

  2024cites this paper
• Cost-effective strategies to knock down genes of interest in the retinas of adult zebrafish

  2024cites this paper
• Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

  2024cites this paper
• Superior target genes and pathways for RNAi‐mediated pest control revealed by genome‐wide analysis in the beetle Tribolium castaneum

  2024cites this paper
• Engineering lentivirus envelope VSV-G for liver targeted delivery of IDOL-shRNA to ameliorate hypercholesterolemia and atherosclerosis

  2024cites this paper
• “BioClay™”: One Step toward the Sustainable and Novel Plant Protection Method

  2024cites this paper
• G-Quadruplexes in the Regulation of Viral Gene Expressions and Their Impacts on Controlling Infection

  2024cites this paper
• The helicase domain of human Dicer prevents RNAi-independent activation of antiviral and inflammatory pathways

  2024cites this paper
• A putative endonuclease reduces the efficiency of oral RNA interference in Nilaparvata lugens.

  2024cites this paper
• Immunomodulatory Molecules in Colorectal Cancer Liver Metastasis.

  2024cites this paper
• Potential microRNA-Disease Association Prediction Using Node2vec and Singular Value Decomposition

  2024cites this paper
• MHESMMR: a multilevel model for predicting the regulation of miRNAs expression by small molecules

  2024cites this paper