Epidermal cell junctions and their regulation by p63 in health and disease

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell and Tissue Research

• Publication date

  2015-02-03

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00441-014-2108-1PMID 25645146
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus

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• p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis

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• RNA-seq studies reveal new insights into p63 and the transcriptomic landscape of the mouse skin.

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• Nectin-4 mutations causing ectodermal dysplasia with syndactyly perturb the rac1 pathway and the kinetics of adherens junction formation.

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• Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.

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• Integrating Animal Models and In Vitro Tissue Models to Elucidate the Role of Desmosomal Proteins in Diseases

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• Architecture of tight junctions and principles of molecular composition.

  2014cited by this paper
• Modeling AEC—New approaches to study rare genetic disorders

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• The desmosomal protein Desmoglein 1 aids recovery of epidermal differentiation after acute ultraviolet light exposure

  2014cited by this paper
• The Desmosomal Protein Desmoglein 1 Aids Recovery of Epidermal Differentiation after Acute UV Light

  2014cited by this paper
• Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification.

  2014cited by this paper
• Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

  2013cited by this paper
• Keratins control intercellular adhesion involving PKC-α–mediated desmoplakin phosphorylation

  2013cited by this paper
• APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

  2013cited by this paper
• An allelic series of Trp63 mutations defines TAp63 as a modifier of EEC syndrome

  2013cited by this paper
• CD151 restricts the α6 integrin diffusion mode

  2012cited by this paper
• Novel molecular therapies for heritable skin disorders.

  2012cited by this paper
• Governing epidermal homeostasis by coupling cell–cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis

  2012cited by this paper
• Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

  2012cited by this paper
• Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

  2012influential reference
• Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63.

  2012cited by this paper
• The role of nectins in different types of cell–cell adhesion

  2012cited by this paper
• ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

  2012cited by this paper
• Desmosomal genodermatoses

  2012cited by this paper
• Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology

  2012cited by this paper
• DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa.

  2012cited by this paper
• Integrin α3 mutations with kidney, lung, and skin disease.

  2012influential reference
• Thinking outside the cell: how cadherins drive adhesion.

  2012cited by this paper
• p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

  2012cited by this paper
• ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

  2011cited by this paper
• Fonction inattendue de p63 dans le développement cardiaque - Un phénotype peut en cacher un autre

  2011cited by this paper
• [Unexpected role for p63 during heart development: one phenotype can hide another one].

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• Mutation in PVRL4 gene encoding nectin-4 underlies ectodermal-dysplasia-syndactyly syndrome (EDSS1)

  2011cited by this paper
• DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

  2011cited by this paper
• p63, a story of mice and men.

  2011cited by this paper
• Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entity.

  2011cited by this paper
• Basement membranes: cell scaffoldings and signaling platforms.

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• The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling

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• Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

  2011influential reference
• Desmoglein as a target in skin disease and beyond

  2011cited by this paper
• Limbal stem-cell therapy and long-term corneal regeneration.

  2010cited by this paper
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  2010cited by this paper
• Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.

  2010cited by this paper
• A homozygous nonsense mutation within the dystonin gene coding for the coiled-coil domain of the epithelial isoform of BPAG1 underlies a new subtype of autosomal recessive epidermolysis bullosa simplex.

  2010cited by this paper
• Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing ΔNp63α

  2010cited by this paper
• TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

  2010cited by this paper
• The C-terminus of p63 contains multiple regulatory elements with different functions

  2010cited by this paper
• Adherens Junctions, Desmosomes and Tight Junctions in Epidermal Barrier Function

  2010cited by this paper
• Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.

  2010cited by this paper
• Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

  2010cited by this paper
• Ligand Targeting of EphA2 Enhances Keratinocyte Adhesion and Differentiation via Desmoglein 1

  2010cited by this paper
• Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis

  2009cited by this paper
• Dermatologic findings of ankyloblepharon‐ectodermal defects‐cleft lip/palate (AEC) syndrome

  2009cited by this paper
• TAp63 prevents premature aging by promoting adult stem cell maintenance.

  2009cited by this paper
• Laminins

  2009cited by this paper
• Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

  2009cited by this paper
• Classical cadherins regulate desmosome formation.

  2009cited by this paper
• A homozygous nonsense mutation in the human desmocollin-3 (DSC3) gene underlies hereditary hypotrichosis and recurrent skin vesicles.

  2009cited by this paper
• The epidermal differentiation‐associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation

  2009cited by this paper
• Spectrum of p63 mutations in a selected patient cohort affected with ankyloblepharon‐ectodermal defects‐cleft lip/palate syndrome (AEC)

  2009cited by this paper
• p63 Suppresses Non-epidermal Lineage Markers in a Bone Morphogenetic Protein-dependent Manner via Repression of Smad7*

  2009cited by this paper
• External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

  2009cited by this paper
• TAp63 induces senescence and suppresses tumorigenesis in vivo

  2009cited by this paper
• ΔNp63 knockdown mice: A mouse model for AEC syndrome

  2009cited by this paper
• Pathologic changes of skin and hair in ankyloblepharon‐ectodermal defects‐cleft lip/palate (AEC) syndrome

  2009cited by this paper
• Involvement of members of the cadherin superfamily in cancer.

  2009cited by this paper
• Loss of desmocollin 3 in mice leads to epidermal blistering

  2008cited by this paper
• The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice

  2008cited by this paper
• Claudin-1 Is a p63 Target Gene with a Crucial Role in Epithelial Development

  2008cited by this paper
• Plakophilin 2: a critical scaffold for PKC (cid:2) that regulates intercellular junction assembly

  2008cited by this paper
• New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity

  2008cited by this paper
• A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes.

  2008cited by this paper
• Plakophilin 2: a critical scaffold for PKCα that regulates intercellular junction assembly

  2008cited by this paper
• P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle

  2008cited by this paper
• Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering.

  2008cited by this paper
• Desmoplakin is essential for epidermal sheet formation.

  2007influential reference
• p63-Associated Disorders

  2007cited by this paper
• Calcium-independent desmosomes of keratinocytes are hyper-adhesive.

  2007cited by this paper
• p63 induces key target genes required for epidermal morphogenesis

  2007influential reference
• p63 Is essential for the proliferative potential of stem cells in stratified epithelia.

  2007cited by this paper
• Cadherins in development: cell adhesion, sorting, and tissue morphogenesis.

  2006cited by this paper
• p63 protects the female germ line during meiotic arrest

  2006cited by this paper
• p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

  2006cited by this paper
• Mechanisms of cutaneous toxicities to EGFR inhibitors

  2006cited by this paper
• Current insights into the formation and breakdown of hemidesmosomes.

  2006cited by this paper
• New p63 targets in keratinocytes identified by a genome‐wide approach

  2006influential reference
• The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.

  2006cited by this paper
• The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia.

  2006cited by this paper
• Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.

  2006cited by this paper
• p63 regulates an adhesion programme and cell survival in epithelial cells

  2006influential reference
• Confirmation of the origin of NISCH syndrome

  2006cited by this paper
• p63 regulates proliferation and differentiation of developmentally mature keratinocytes.

  2006influential reference
• Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes

  2006cited by this paper
• The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.

  2006cited by this paper
• Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells.

  2006cited by this paper
• An Autoregulatory Loop Directs the Tissue-Specific Expression of p63 through a Long-Range Evolutionarily Conserved Enhancer

  2006cited by this paper
• The Unique NH2-terminally Deleted (ΔN) Residues, the PXXP Motif, and the PPXY Motif Are Required for the Transcriptional Activity of the ΔN Variant of p63*

  2006cited by this paper
• Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome)

  2005cited by this paper
• Perp is a p63-regulated gene essential for epithelial integrity.

  2005influential reference
• Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development

  2005cited by this paper

• Molecular and Cellular Function of p63 in Skin Development and Genetic Diseases.

  2024cites this paper
• ΔNp63 controls stemness and inflammation in the adult epidermis

  2022cites this paper
• Isoform-Specific Roles of Mutant p63 in Human Diseases

  2021cites this paper
• Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells.

  2020cites this paper
• Single-cell RNA-seq identifies a reversible epithelial-mesenchymal transition in abnormally specified epithelia of p63 EEC syndrome

  2018cites this paper
• KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis

  2018influential citation
• Functional and Mechanistic Insights into the Pathogenesis of P63-Associated Disorders.

  2018cites this paper
• Structural and functional consequences of p63 mutations causative of AEC syndrome

  2018cites this paper
• ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82

  2017cites this paper
• Closing the Gap: Mouse Models to Study Adhesion in Secondary Palatogenesis

  2017cites this paper
• UNIVERSITY OF NAPOLI FEDERICO II Doctorate School in Molecular Medicine Doctorate Program in Genetics and Molecular Medicine Coordinator: Prof. Lucio Nitsch XXVII Cycle “Molecular mechanisms at the basis of epidermal defects and skin fragility in AEC syndrome”

  2015cites this paper
• Junctions in human health and inherited disease

  2015cites this paper