Translation Initiation Factor 2γ Mutant Alters Start Codon Selection Independent of Met-tRNA Binding

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecular and Cellular Biology

• Publication date

  2008-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01147-08PMID 18794367PMCID PMC2573310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.

  2007cited by this paper
• Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states

  2007cited by this paper
• The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.

  2007cited by this paper
• Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon.

  2006cited by this paper
• Direct Binding of Translation Initiation Factor eIF2γ-G Domain to Its GTPase-activating and GDP-GTP Exchange Factors eIF5 and eIF2Bϵ*

  2006cited by this paper
• Intragenic Suppressor Mutations Restore GTPase and Translation Functions of a Eukaryotic Initiation Factor 5B Switch II Mutant

  2006cited by this paper
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  2005cited by this paper
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  2005influential reference
• Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation.

  2005influential reference
• Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection

  2004cited by this paper
• GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2.

  2004influential reference
• Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP.

  2004cited by this paper
• X-ray Structure of Translation Initiation Factor eIF2γ

  2004cited by this paper
• X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding.

  2004cited by this paper
• The Yeast Eukaryotic Initiation Factor 4G (eIF4G) HEAT Domain Interacts with eIF1 and eIF5 and Is Involved in Stringent AUG Selection

  2003cited by this paper
• Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing.

  2003cited by this paper
• The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors

  2002cited by this paper
• The Guanine Nucleotide-Binding Switch in Three Dimensions

  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• 12 Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae

  2000cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1989cited by this paper
• Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA.

  1989cited by this paper
• Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

  1988cited by this paper
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  1988cited by this paper
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• eIF2β zinc-binding domain interacts with the eIF2γ subunit through the guanine nucleotide binding interface to promote Met-tRNAiMet binding

  2024cites this paper
• eIF4F complex dynamics are important for the activation of the integrated stress response

  2024cites this paper
• The molecular basis of translation initiation and its regulation in eukaryotes

  2023cites this paper
• Wide mutational analysis to ascertain the functional roles of eL33 in ribosome biogenesis and translation initiation

  2022cites this paper
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  2022cites this paper
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  2021cites this paper
• Predicting gene phenotype by multi-label multi-class model based on essential functional features

  2021cites this paper
• eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide

  2020cites this paper
• Ribosomal mutation in helix 32 of 18S rRNA alters fidelity of eukaryotic translation start site selection

  2019cites this paper
• Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation

  2019cites this paper
• Fidelity of HIS4 start codon selection influences 3-amino-1,2,4-triazole sensitivity in GTPase activating protein function defective eIF5

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• MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNAiMet binding to eukaryotic translation initiation factor eIF2

  2018influential citation
• eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex

  2018cites this paper
• Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans

  2017cites this paper
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  2017cites this paper
• Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation.

  2017cites this paper
• eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

  2017cites this paper
• EIF2S3 Mutations Associated with Severe X‐Linked Intellectual Disability Syndrome MEHMO

  2017influential citation
• eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control

  2016cites this paper
• An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

  2015cites this paper
• Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis

  2015cites this paper
• The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

  2015cites this paper
• Cwf16p Associating with the Nineteen Complex Ensures Ordered Exon Joining in Constitutive Pre-mRNA Splicing in Fission Yeast

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• Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon

  2014cites this paper
• The scanning mechanism of eukaryotic translation initiation.

  2014cites this paper
• Examining the role yeast initiator tRNA sequence and structure plays in communicating start codon recognition

  2014cites this paper
• Phosphorylation Stoichiometries of Human Eukaryotic Initiation Factors

  2014cites this paper
• Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation

  2014cites this paper
• Influence of translation factor activities on start site selection in six different mRNAs

  2013cites this paper
• β-Hairpin Loop of Eukaryotic Initiation Factor 1 (eIF1) Mediates 40 S Ribosome Binding to Regulate Initiator tRNAMet Recruitment and Accuracy of AUG Selection in Vivo * ♦

  2013cites this paper
• Coordinated Movements of Eukaryotic Translation Initiation Factors eIF1, eIF1A, and eIF5 Trigger Phosphate Release from eIF2 in Response to Start Codon Recognition by the Ribosomal Preinitiation Complex*

  2013cites this paper
• ESTABLISHING THE FIDELITY OF START CODON RECOGNITION: ROLE OF EUKARYOTIC INITIATION FACTOR 2

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• ‘Ribozoomin’ – Translation Initiation from the Perspective of the Ribosome-bound Eukaryotic Initiation Factors (eIFs)

  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.

  2012cites this paper
• Phosphorylation of human eukaryotic initiation factor 2γ: novel site identification and targeted PKC involvement.

  2011cites this paper
• Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

  2011cites this paper
• Eukaryotic type translation initiation factor 2: Structure–functional aspects

  2011cites this paper
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  2011cites this paper
• The β/Gcd7 Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2B), a Guanine Nucleotide Exchange Factor, Is Crucial for Binding eIF2 In Vivo

  2010cites this paper
• Molecular View of 43 S Complex Formation and Start Site Selection in Eukaryotic Translation Initiation*

  2010cites this paper
• Expression and purification of recombinant wheat translation initiation factor eIF2

  2010cites this paper