Hypoxia and High Altitude

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Advances in Experimental Medicine and Biology

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1007/978-1-4419-8997-0_7
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Vascular endothelial growth factor in patients with high-altitude pulmonary edema.

  2003cited by this paper
• Long-term exposure to intermittent hypoxia results in increased hemoglobin mass, reduced plasma volume, and elevated erythropoietin plasma levels in man

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• Hypoxic up-regulation of erythroid 5-aminolevulinate synthase.

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• Pituitary adenylate cyclase‐activating polypeptide (PACAP) stimulates endozepine release from cultured rat astrocytes via a PKA‐dependent mechanism

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• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

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• Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, RTP801, Involved in Apoptosis

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• Regulation and Destabilization of HIF-1 by ARD1-Mediated Acetylation

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• Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain.

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• Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response

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• Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP

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• Airway chemotransduction: from oxygen sensor to cellular effector.

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• p38 Signaling-mediated Hypoxia-inducible Factor 1α and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells*

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• Phosphatidylinositol 3-Kinase/Akt Signaling Is Neither Required for Hypoxic Stabilization of HIF-1α nor Sufficient for HIF-1-dependent Target Gene Transcription*

  2002cited by this paper
• Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

  2002cited by this paper
• Hypoxia-inducible Factor-1-mediated Expression of the 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) Gene

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• Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells*

  2002cited by this paper
• Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension*

  2002cited by this paper
• c-Jun and Hypoxia-Inducible Factor 1 Functionally Cooperate in Hypoxia-Induced Gene Transcription

  2002cited by this paper
• The bHLH/PAS factor MOP3 does not participate in hypoxia responses.

  2002cited by this paper
• Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

  2002cited by this paper
• Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.

  2002cited by this paper
• Normoxic induction of the hypoxia‐inducible factor 1α by insulin and interleukin‐1β involves the phosphatidylinositol 3‐kinase pathway

  2002cited by this paper
• Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus*

  2002cited by this paper
• Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases.

  2002cited by this paper
• Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

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• Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

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• Mitogen-Activated Protein Kinase Kinase Inhibitor PD98059 Blocks the trans-Activation but Not the Stabilization or DNA Binding Ability of Hypoxia-Inducible Factor-1α

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• The target of rapamycin (TOR) proteins

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• Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α

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• Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia.

  2001cited by this paper
• Attenuation of HIF-1 DNA-binding activity limits hypoxia-inducible endothelin-1 expression

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• Induction of HIF–1α in response to hypoxia is instantaneous

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• The ups and downs of MEK kinase interactions.

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• A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

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• Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply.

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• Effects of high-altitude exposure on vascular endothelial growth factor levels in man

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain.

  2001cited by this paper
• HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia

  2001cited by this paper
• Muscle tissue adaptations to hypoxia.

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• p300/CBP proteins: HATs for transcriptional bridges and scaffolds.

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• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

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• Regulation of translation initiation by FRAP/mTOR.

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• Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.

  2001cited by this paper
• Role of vascular endothelial growth factor in regulation of physiological angiogenesis.

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• Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions.

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• Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells: Role of the p22phox-Containing NADPH Oxidase

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• Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide*

  2001cited by this paper
• A non‐hypoxic, ROS‐sensitive pathway mediates TNF‐α‐dependent regulation of HIF‐1α

  2001cited by this paper
• c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells.

  2001cited by this paper
• Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

  2001cited by this paper
• Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

  2001cited by this paper
• HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

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• Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway*

  2001cited by this paper
• Frontiers of hypoxia research: acute mountain sickness.

  2001cited by this paper
• Dissecting hypoxia‐dependent and hypoxia‐independent steps in the HIF‐1α activation cascade: implications for HIF‐1α gene therapy

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• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  2001cited by this paper
• Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

  2000cited by this paper
• Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

  2000cited by this paper
• VHL takes HIF’s breath away

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• Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis.

  2000cited by this paper
• Mammalian oxygen sensing, signalling and gene regulation.

  2000cited by this paper
• Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia.

  2000cited by this paper
• Plasma vascular endothelial growth factor in acute mountain sickness.

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• The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia.

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• TOR, a central controller of cell growth.

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• Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions.

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• Comparative aspects of high-altitude adaptation in human populations.

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• A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor*

  2000cited by this paper
• Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

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• Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain.

  2000cited by this paper
• Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia.

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• Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

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• Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

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• Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

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• Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

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• Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells*

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• Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts.

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• Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.

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• Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells.

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• Role of Hypoxia-inducible Factor-1 in Transcriptional Activation of Ceruloplasmin by Iron Deficiency*

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• O2-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis

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• Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein*

  2000cited by this paper
• Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1α and NF-κB Redox Sensitivity

  2000cited by this paper
• Adaptation and conservation of physiological systems in the evolution of human hypoxia tolerance.

  1999cited by this paper
• High altitude cerebral edema and acute mountain sickness. A pathophysiology update.

  1999cited by this paper
• Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: their stabilization and redox signal‐induced interaction with CBP/p300

  1999cited by this paper
• Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha.

  1999cited by this paper
• Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

  1999cited by this paper
• Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins.

  1999cited by this paper
• Identification of a Hypoxia Response Element in the Transferrin Receptor Gene*

  1999cited by this paper
• Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha.

  1999cited by this paper
• Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway*

  1999cited by this paper
• Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes.

  1999cited by this paper
• p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1*

  1999cited by this paper
• General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia‐inducible factor 1α

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• New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

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• Transferrin Receptor Induction by Hypoxia

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• Nix and Nip3 Form a Subfamily of Pro-apoptotic Mitochondrial Proteins*

  1999cited by this paper
• Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

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• Calycosin ameliorates high-altitude pulmonary edema by regulating macrophage polarization through the PPAR-γ/NF-κB pathway: a comprehensive analysis of network pharmacology, molecular docking, and experimental validation.

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• Ligustrazine hydrochloride Prevents Ferroptosis by Activating the NRF2 Signaling Pathway in a High-Altitude Cerebral Edema Rat Model

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• Fluorescent probes for biomolecule detection under environmental stress.

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• Characterization of the Impacts of Living at High Altitude in Taif: Oxidative Stress Biomarker Alterations and Immunohistochemical Changes

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• The role of post-translational modifications in driving abnormal cardiovascular complications at high altitude

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• Mild hypobaric hypoxia influences splenic proliferation during the later phase of stress erythropoiesis

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• Adaptation to Life in the High Andes: Nocturnal Oxyhemoglobin Saturation in Early Development.

  2016cites this paper
• Size restricted silymarin suspension evokes integrated adaptive response against acute hypoxia exposure in rat lung.

  2016cites this paper
• Oxidative stress at high altitude: genotype–phenotype correlations

  2014cites this paper
• Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure

  2014cites this paper
• Physiology of high-altitude acclimatization

  2014cites this paper
• Effect of Iron Supplementation on the Expression of Hypoxia-Inducible Factor and Antioxidant Status in Rats Exposed to High-Altitude Hypoxia Environment

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• Effect of Vitamin E Supplementation on Intestinal Barrier Function in Rats Exposed to High Altitude Hypoxia Environment

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• Effect of Subchronic Hypobaric Hypoxia on Oxidative Stress in Rat Heart

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• Red Blood Cell Volume and the Capacity for Exercise at Moderate to High Altitude

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• Individualized Intermittent Hypoxia Training: Principles and Practices

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• Cdk5 interacts with Hif-1α in neurons: a new hypoxic signalling mechanism?

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• Astrocytes and Pericytes Differentially Modulate Blood—Brain Barrier Characteristics during Development and Hypoxic Insult

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• Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.

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• Molecular characterization of hypoxia and hypoxia-inducible factor 1 alpha (HIF-1α) from Taiwan voles (Microtus kikuchii).

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• Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.

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• Gene Expression in Chronic High Altitude Diseases

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• Prolyl hydroxylase inhibitor treatment confers whole‐animal hypoxia tolerance

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• Cloning and expression of hypoxia-inducible factor 1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus.

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• INTERMITTENT VERSUS CONTINUOUS HYPOXIA: IMPACT ON HEMODYNAMIC VARIABLES AND GENE EXPRESSION

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• Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha.

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• Hypoxia-lnduced Changes in Neurona! Network Properties

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• Rescue of lethal c-KitW/W mice by erythropoietin.

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• Oxygen Sensing in the Circulation: "Cross Talk" Between Red Blood Cells and the Vasculature

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