Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein‐coupled receptor structure and function

No abstract is available for this paper.

• Publication year

  2018

• Venue

  British Journal of Pharmacology

• Publication date

  2018-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/bph.13943PMID 28691227PMCID PMC6177615
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype.

  2017influential reference
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