Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Nature Reviews Rheumatology

• Publication date

  2011-08-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrrheum.2011.109PMID 21808292PMCID PMC3192496
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Recent progress toward biomarker identification in osteoarthritis.

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  2009cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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