The occurrence of a protein in the extracellular products of streptococci isolated from patients with acute glomerulonephritis

The present report compares the extracellular proteins of streptococci by sodium dodecyl sulfate polyacrylamide electrophoresis. A marked variation in the streptococcal extracellualr proteins (SEP) of different strains was detected, even in strains of similar serotypes. It was possible, however, to identify a single protein band that occurred predominantly in the SEP of strains isolated from patients with acute poststreptococcal glomerulonephritis (APSGN). This protein was generally not produced by streptococci obtained from patients without this disease. It appears to be immunologically similar in the various serotypes of streptococci isolated from patients with APSGN and can be demonstrated by immunofluorescence techniques to be present in the glomeruli of these patients.

• Publication year

  1979

• Venue

  Journal of Experimental Medicine

• Publication date

  1979-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.149.2.459PMID 368288PMCID 2184797
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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