Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  American Journal of Physiology. Heart and Circulatory Physiology

• Publication date

  2004-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/AJPHEART.01055.2003PMID 14684373PMCID PMC3713476
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein tyrosine kinase signaling is necessary for NO donor-induced late preconditioning against myocardial stunning.

  2003cited by this paper
• Mitochondrial K ATP channel activation is important in the antiarrhythmic and cardioprotective effects of non-hypotensive doses of nicorandil and cromakalim during ischemia/reperfusion: a study in an intact anesthetized rabbit model.

  2003cited by this paper
• Second window of ischemic preconditioning regulates mitochondrial permeability transition pore by enhancing Bcl-2 expression.

  2003influential reference
• Intravenous nicorandil in conjunction with coronary reperfusion therapy is associated with better clinical and functional outcomes in patients with acute myocardial infarction.

  2003cited by this paper
• Infarct size limitation by nicorandil: roles of mitochondrial K(ATP) channels, sarcolemmal K(ATP) channels, and protein kinase C.

  2002cited by this paper
• Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits.

  2002influential reference
• COX-2-derived prostacyclin mediates opioid-induced late phase of preconditioning in isolated rat hearts.

  2002cited by this paper
• Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial.

  2002influential reference
• Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits.

  2002cited by this paper
• ATP is released from guinea pig ureter epithelium on distension.

  2002cited by this paper
• Nicorandil-induced preconditioning as evidenced by troponin T measurements after coronary angioplasty in patients with stable angina pectoris.

  2002cited by this paper
• Effects of administration of nicorandil or bimakalim prior to and during ischemia or reperfusion on survival rate, ischemia/reperfusion-induced arrhythmias and infarct size in anesthetized rabbits

  2001cited by this paper
• Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor

  2001cited by this paper
• Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil.

  2001cited by this paper
• Nitroglycerin and delayed preconditioning in humans: yet another new mechanism for an old drug?

  2001cited by this paper
• Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits Despite Development of Nitrate Tolerance

  2001influential reference
• Nicorandil, a hybrid between nitrate and ATP-sensitive potassium channel opener, preconditions human heart to ischemia during percutaneous transluminal coronary angioplasty.

  2001cited by this paper
• BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation.

  2001cited by this paper
• Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits Despite Development of Nitrate Tolerance

  2001influential reference
• A1 or A3 Adenosine Receptors Induce Late Preconditioning Against Infarction in Conscious Rabbits by Different Mechanisms

  2001cited by this paper
• Delayed Preconditioning-Mimetic Action of Nitroglycerin in Patients Undergoing Coronary Angioplasty

  2001cited by this paper
• Cyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors.

  2001cited by this paper
• Differential role of KATP channels in late preconditioning against myocardial stunning and infarction in rabbits

  2001cited by this paper
• Differential role of K(ATP) channels in late preconditioning against myocardial stunning and infarction in rabbits.

  2000cited by this paper
• Cardioprotective Effects Of Nicorandil In Rabbits Anaesthetized With Halothane: Potentiation Of Ischaemic Preconditioning Via KATP Channels

  2000cited by this paper
• Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

  2000cited by this paper
• Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease.

  2000influential reference
• Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits.

  2000influential reference
• Cardioprotection by opening of the K(ATP) channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization.

  1999cited by this paper
• Opening of mitochondrial KATPchannel induces early and delayed cardioprotective effect: role of nitric oxide.

  1999cited by this paper
• Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.

  1999cited by this paper
• Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway.

  1999cited by this paper
• Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning.

  1999cited by this paper
• Opening of mitochondrial KATP channel induces early and delayed cardioprotective effect : role of nitric oxide

  1999cited by this paper
• Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction.

  1999cited by this paper
• Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway.

  1999influential reference
• Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice.

  1999cited by this paper
• Cardioprotection by opening of the KATPchannel in unstable anginaIs this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil

  1999cited by this paper
• Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway.

  1999cited by this paper
• Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism.

  1998influential reference
• Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved.

  1998cited by this paper
• Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits.

  1998cited by this paper
• Evidence of pharmacologic preconditioning during PTCA by intravenous pretreatment with ATP-sensitive K+ channel opener nicorandil.

  1998influential reference
• Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo.

  1998cited by this paper
• Salutary effect of adjunctive intracoronary nicorandil administration on restoration of myocardial blood flow and functional improvement in patients with acute myocardial infarction.

  1997cited by this paper
• Premedication with the opioid analgesic butorphanol raises the threshold for ischemic preconditioning in dogs

  1997cited by this paper
• Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits.

  1997cited by this paper
• The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning.

  1997cited by this paper
• Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide.

  1997cited by this paper
• Epicardial temperature is a major predictor of myocardial infarct size in dogs.

  1997cited by this paper
• Nicorandil reduces myocardial infarct size by opening the K(ATP) channel in rabbits.

  1997cited by this paper
• An ATP-sensitive potassium (KATP) channel opener, nicorandil, lowers the threshold for ischemic preconditioning in barbital-anesthetized dogs.

  1997cited by this paper
• Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity.

  1997influential reference
• Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs.

  1996cited by this paper
• Effect of temperature on myocardial infarction in swine.

  1996cited by this paper
• Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog.

  1995cited by this paper
• Antiischemic effects of nicorandil during coronary angioplasty in humans

  1995cited by this paper
• Limitation of Myocardial Infarct Size by Nicorandil After Sustained Ischemia in Pigs

  1995cited by this paper
• Adenosine Receptor Involvement in a Delayed Phase of Myocardial Protection 24 Hours After Ischemic Preconditioning

  1994cited by this paper
• Anaesthetics alter the magnitude of infarct limitation by ischaemic preconditioning.

  1994cited by this paper
• Cardioprotective effects of monophosphoryl lipid A, a novel endotoxin analogue, in the dog.

  1993cited by this paper
• EFFECT OF NICORANDIL ON POST‐ISCHAEMIC CONTRACTILE DYSFUNCTION IN THE HEART: ROLES OF ITS ATP‐SENSITIVE K’ CHANNEL OPENING PROPERTY AND NITRATE PROPERTY

  1993cited by this paper
• Nicorandil Attenuates Myocardial Dysfunction Associated with Transient Ischemia by Opening ATP-Dependent Potassium Channels

  1992cited by this paper
• Cardioprotective Effects of Nicorandil

  1992cited by this paper
• Molecular Mechanism of Action of Nicorandil

  1992cited by this paper
• Dual Mechanism of the Relaxing Effect of Nicorandil by Stimulation of Cyclic GMP Formation and by Hyperpolarization

  1991cited by this paper
• Action of nicorandil on ATP‐sensitive K+ channel in guinea‐pig ventricular myocytes

  1991cited by this paper
• Nitrate Tolerance

  1989cited by this paper
• Protective effect of nicorandil on postischemic function and tissue adenine nucleotides following a brief period of low-flow global ischemia in the isolated perfused rat heart.

  1989cited by this paper
• Salutary action of nicorandil, a new antianginal drug, on myocardial metabolism during ischemia and on postischemic function in a canine preparation of brief, repetitive coronary artery occlusions: comparison with isosorbide dinitrate.

  1987cited by this paper
• Similarity and Dissimilarity in the Mode and Mechanism of Action Between Nicorandil and Classical Nitrates: An Overview

  1987cited by this paper
• Comparative Effects of Nicorandil, a Nicotinamide Nitrate Derivative, and Nifedipine on Myocardial Reperfusion Injury in Dogs

  1987cited by this paper
• Recovery of contractile function in post-ischaemic reperfused myocardium of conscious dogs: influence of nicorandil, a new antianginal agent.

  1986cited by this paper
• Improved Recovery of Myocardial Segment Function Following a Short Coronary Occlusion in Dogs by Nicorandil, a Potential New Antianginal Agent, and Nifedipine

  1985cited by this paper
• Effects of Nicorandil and Nifedipine on Protection of Ischemic Myocardium

  1984cited by this paper
• Nuclear Factor- (cid:107) B Plays an Essential Role in the Late Phase of Ischemic Preconditioning in Conscious Rabbits

  year unknowncited by this paper

• Therapeutic potential of nicorandil beyond anti-anginal drug: A review on current and future perspectives

  2024cites this paper
• Proteomic Analysis Reveals Differential Protein Expression Induced by Inhibition of Prolyl Oligopeptidase in Filarial Parasites

  2022cites this paper
• Cardiovascular events associated with nicorandil administration prior to primary percutaneous coronary intervention in patients with acute ST-segment elevated myocardial infarction: a systematic review and meta-analysis

  2019cites this paper
• Role of Calcium Channel Blockers in Myocardial Preconditioning

  2017cites this paper
• KATP Channels in the Cardiovascular System.

  2016cites this paper
• Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway

  2015cites this paper
• The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.

  2015cites this paper
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  2015cites this paper
• GATA-4 Transcription Factor Regulates Cardiac COX-2 Expression Induced by Nicorandil in Left Ventricle of Rats

  2014cites this paper
• Nicorandil Ameliorated Hypertensive Renal Injury without Lowering Blood Pressure in Spontaneously Hypertensive Rats

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• Coronary microvascular reperfusion injury and no-reflow in acute myocardial infarction.

  2007cites this paper
• The cardioprotection of the late phase of ischemic preconditioning is enhanced by postconditioning via a COX-2-mediated mechanism in conscious rats.

  2007cites this paper
• Nicorandil decreases cardiac events during and after noncardiac surgery.

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• Ischaemic preconditioning: from molecular characterisation to clinical application--part II.

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