Human platelets synthesize and express functional tissue factor.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Blood

• Publication date

  2007-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2006-06-030619PMID 17347408
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation 1

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• Tissue factor encryption.

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• Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation.

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• Tissue factor activity in whole blood.

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• Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall.

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• Platelets and tissue factor

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• Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa.

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• Platelets synthesize large amounts of active plasminogen activator inhibitor 1.

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• Thrombin and Tumor Necrosis Factor α Synergistically Stimulate Tissue Factor Expression in Human Endothelial Cells

  2004cited by this paper
• Tissue factor in neutrophils: yes

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• Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation.

  2004cited by this paper
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  2003cited by this paper
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• Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

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• Biosynthesis of major platelet proteins in human blood platelets.

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