Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cell Science

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.062075PMID 20053638PMCID PMC2816182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase.

  2008influential reference
• Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

  2008cited by this paper
• CMF1–Rb interaction promotes myogenesis in avian skeletal myoblasts

  2008cited by this paper
• The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

  2008cited by this paper
• Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.

  2008cited by this paper
• The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

  2008influential reference
• Activating transcription factor 4.

  2008cited by this paper
• Genomic stability and tumour suppression by the APC/C cofactor Cdh1

  2008cited by this paper
• CENP‐F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer

  2007cited by this paper
• Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase.

  2007cited by this paper
• Farnesyl transferase inhibitors impair chromosomal maintenance in cell lines and human tumors by compromising CENP-E and CENP-F function

  2007influential reference
• Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.

  2007cited by this paper
• Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C

  2007cited by this paper
• NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores

  2007cited by this paper
• The processivity of multiubiquitination by the APC determines the order of substrate degradation.

  2006cited by this paper
• Protein Phosphatase 2A Stabilizes Human Securin, Whose Phosphorylated Forms Are Degraded via the SCF Ubiquitin Ligase

  2006cited by this paper
• Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction

  2006cited by this paper
• The anaphase promoting complex/cyclosome: a machine designed to destroy

  2006cited by this paper
• Validating Aurora B as an anti-cancer drug target

  2006cited by this paper
• Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4*

  2005cited by this paper
• Unstable microtubule capture at kinetochores depleted of the centromere‐associated protein CENP‐F

  2005cited by this paper
• Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20

  2005cited by this paper
• FoxM1 is required for execution of the mitotic programme and chromosome stability

  2005cited by this paper
• Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint

  2005cited by this paper
• Silencing Mitosin Induces Misaligned Chromosomes, Premature Chromosome Decondensation before Anaphase Onset, and Mitotic Cell Death

  2005cited by this paper
• Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage

  2005cited by this paper
• Tools to analyze protein farnesylation in cells.

  2005cited by this paper
• Moving past proliferation: new roles for Cdh1-APC in postmitotic neurons.

  2005cited by this paper
• Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability

  2004cited by this paper
• Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

  2004influential reference
• Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning.

  2004cited by this paper
• A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.

  2004cited by this paper
• Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

  2002influential reference
• Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis.

  2002cited by this paper
• The Farnesyltransferase Inhibitor, FTI-2153, Blocks Bipolar Spindle Formation and Chromosome Alignment and Causes Prometaphase Accumulation during Mitosis of Human Lung Cancer Cells*

  2001cited by this paper
• Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells.

  2001influential reference
• APC/C‐mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A‐type D‐box

  2001cited by this paper
• Activity of the APCCdh1 form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p

  2001cited by this paper
• Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase

  2001cited by this paper
• Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules*

  2000cited by this paper
• Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis

  2000cited by this paper
• Mitotic regulation of the APC activator proteins CDC20 and CDH1.

  2000influential reference
• The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.

  2000cited by this paper
• Temporal and spatial control of cyclin B1 destruction in metaphase

  1999influential reference
• pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation.

  1999cited by this paper
• Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex.

  1998influential reference
• The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

  1998influential reference
• Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle

  1996cited by this paper
• Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast.

  1995cited by this paper
• CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis

  1995influential reference
• A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B.

  1995cited by this paper
• The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

  1995cited by this paper
• The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase

  1994cited by this paper
• Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis

  1994cited by this paper
• CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization.

  1993cited by this paper
• The effect of posttranslational modifications on the interaction of Ras2 with adenylyl cyclase

  1993cited by this paper
• Recombinase-mediated gene activation and site-specific integration in mammalian cells.

  1991cited by this paper
• Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

  1991cited by this paper

• Farnesylation-Dependent Kinetochore Targeting of CENP-F Is Essential for Oocyte Meiotic Progression and Female Fertility.

  2025cites this paper
• Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer

  2025cites this paper
• Proteasomal Dysfunction in Cancer: Mechanistic Pathways and Targeted Therapies

  2025cites this paper
• The localisation and stability of the CENP-F protein are regulated by importin beta and microtubules in mitotic cells

  2025cites this paper
• A novel prognostic model in ovarian cancer based on the Nectin family and Necl-like molecules related transcriptomics.

  2025cites this paper
• Targeting APC/CCDC20 by Pro-TAME Suppresses Tumor Proliferation and Induces Apoptosis in Endometrial Carcinoma

  2024cites this paper
• Combined multiomics analysis reveals the mechanism of CENPF overexpression-mediated immune dysfunction in diffuse large B-cell lymphoma in vitro

  2022cites this paper
• STYK1/NOK affects cell cycle late mitosis and directly interacts with anaphase-promoting complex activator CDH1

  2022cites this paper
• Current progress and perspectives of CDC20 in female reproductive cancers.

  2022cites this paper
• Screening of Hub Genes in Hepatocellular Carcinoma Based on Network Analysis and Machine Learning

  2022cites this paper
• Discovery and Validation of a Compound to Target Ewing’s Sarcoma

  2021cites this paper
• In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

  2020cites this paper
• In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

  2020cites this paper
• Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

  2020cites this paper
• The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases

  2019cites this paper
• The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase.

  2019cites this paper
• Loss of CENPF leads to developmental failure in mouse embryos

  2019cites this paper
• Regulation of Cenp-F localization to nuclear pores and kinetochores

  2018cites this paper
• Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice

  2018cites this paper
• Disentangling the molecular determinants for Cenp‐F localization to nuclear pores and kinetochores

  2018cites this paper
• SUMO targets the APC/C to regulate transition from metaphase to anaphase

  2018cites this paper
• 53BP1: A guardian for centrosomal integrity.

  2018cites this paper
• Mechanisms of Chromosome Congression during Mitosis

  2017cites this paper
• Taming the Beast: Control of APC/C-Dependent Destruction

  2017cites this paper
• Taming the Beast: Control of APC/CCdc20-Dependent Destruction.

  2017cites this paper
• Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F

  2017cites this paper
• Plk1-mediated stabilization of 53BP1 through USP7 regulates centrosome positioning to maintain bipolarity

  2017cites this paper
• An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

  2017cites this paper
• CENP-F couples cargo to growing and shortening microtubule ends

  2016cites this paper
• Ubiquitin-Mediated Degradation of Aurora Kinases

  2016influential citation
• Strømme Syndrome Is a Ciliary Disorder Caused by Mutations in CENPF

  2016cites this paper
• Gene expression profiling of pulmonary neuroendocrine neoplasms: a comprehensive overview

  2015cites this paper
• Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules

  2015cites this paper
• Targeting Cdc20 as a novel cancer therapeutic strategy.

  2015cites this paper
• Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

  2015cites this paper
• Characterisation of novel functions of the anaphase promoting complex/cyclosome and its regulation through post-translational modification

  2015cites this paper
• Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

  2015cites this paper
• Mitotic entry: Non-genetic heterogeneity exposes the requirement for Plk1

  2015cites this paper
• The Role of APC E3 Ubiquitin Ligase Complex in Tumorigenesis

  2014cites this paper
• Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction

  2014cites this paper
• SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

  2014cites this paper
• Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis.

  2014cites this paper
• STIL microcephaly mutations interfere with APC/C-mediated degradation and cause centriole amplification.

  2014cites this paper
• CDC20 downregulation impairs spindle morphology and causes reduced first polar body emission during bovine oocyte maturation.

  2014cites this paper
• The spindle checkpoint, APC/CCdc20, and APC/CCdh1 play distinct roles in connecting mitosis to S phase

  2013cites this paper
• Dynactin helps target Polo‐like kinase 1 to kinetochores via its left‐handed beta‐helical p27 subunit

  2013cites this paper
• Nonparametric Bayesian evaluation of differential protein quantification.

  2013cites this paper
• Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks

  2013cites this paper
• The microtubule binding properties of CENP-E's C-terminus and CENP-F.

  2013cites this paper
• Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

  2013cites this paper
• Stem Cells and Prostate Cancer

  2013influential citation
• Cohesion Fatigue Explains Why Pharmacological Inhibition of the APC/C Induces a Spindle Checkpoint-Dependent Mitotic Arrest

  2012cites this paper
• GPS-ARM: Computational Analysis of the APC/C Recognition Motif by Predicting D-Boxes and KEN-Boxes

  2012cites this paper
• Substrate targeting by the ubiquitin-proteasome system in mitosis.

  2012cites this paper
• Processive ubiquitin chain formation by the anaphase-promoting complex.

  2011cites this paper
• BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner

  2011cites this paper
• Using a novel small molecule inhibitor to investigate the role of Mps1 kinase activity

  2011influential citation
• Substrate-specific regulation of ubiquitination by the anaphase-promoting complex

  2011cites this paper
• Anaphase-Promoting Complex/Cyclosome Participates in the Acute Response to Protein-Damaging Stress

  2010cites this paper
• Kinetochore assembly: if you build it, they will come.

  2010cites this paper
• Sustained Mps 1 activity is required in mitosis to recruit O-Mad 2 to the Mad 1 – C-Mad 2 core complex

  2010cites this paper