Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling

In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.

• Publication year

  2017

• Venue

  Experimental &Molecular Medicine

• Publication date

  2017-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/emm.2017.120PMID 28857084PMCID 5579511
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• GM-CSF Grown Bone Marrow Derived Cells Are Composed of Phenotypically Different Dendritic Cells and Macrophages

  2016cited by this paper
• Resource GM-CSF Mouse Bone Mar row Cultures Comprise a Heterogeneous Population of CD 11 c + MHCII + Macrophages and Dendritic Cells Highlights

  2015cited by this paper
• Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4

  2013cited by this paper
• Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.

  2013cited by this paper
• C/EBPα is required for development of dendritic cell progenitors.

  2013cited by this paper
• CISH is induced during DC development and regulates DC‐mediated CTL activation

  2012cited by this paper
• Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy.

  2012cited by this paper
• Cancer immunotherapy via dendritic cells

  2012cited by this paper
• Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

  2011cited by this paper
• Sphingosylphosphorylcholine Stimulates CCL2 Production from Human Umbilical Vein Endothelial Cells

  2011cited by this paper
• The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner.

  2010cited by this paper
• Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model

  2010cited by this paper
• Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice.

  2010cited by this paper
• Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2.

  2009cited by this paper
• Is serum amyloid A an endogenous TLR4 agonist?

  2008cited by this paper
• Differential Development of Murine Dendritic Cells by GM-CSF versus Flt3 Ligand Has Implications for Inflammation and Trafficking1

  2007cited by this paper
• Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation.

  2006cited by this paper
• Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma.

  2006cited by this paper
• Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells.

  2005cited by this paper
• Extrahepatic production of acute phase serum amyloid A.

  2005cited by this paper
• Serum Amyloid A Is a Ligand for Scavenger Receptor Class B Type I and Inhibits High Density Lipoprotein Binding and Selective Lipid Uptake*

  2005cited by this paper
• Identification of Peptides That Antagonize Formyl Peptide Receptor-Like 1-Mediated Signaling1

  2004cited by this paper
• GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells.

  2001cited by this paper
• Immunobiology of dendritic cells.

  2000cited by this paper
• Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis

  1999cited by this paper
• Apolipoprotein serum amyloid A down-regulates smooth-muscle cell lipid biosynthesis.

  1999cited by this paper
• A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells

  1999cited by this paper
• Local expression of acute phase serum amyloid A mRNA in rheumatoid arthritis synovial tissue and cells.

  1999cited by this paper
• Acute-phase proteins and other systemic responses to inflammation.

  1999cited by this paper
• Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-gamma and C/AAAT enhancer binding protein-alpha.

  1999cited by this paper
• PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors

  1998cited by this paper
• Regulation of serum amyloid A protein expression during the acute-phase response.

  1998cited by this paper
• Human Serum Amyloid A has Cytokine‐Like Properties

  1998cited by this paper
• Transcription factors, normal myeloid development, and leukemia.

  1997cited by this paper
• PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene

  1995cited by this paper
• Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

  1994cited by this paper
• Serum amyloid A protein compared with C‐reactive protein, alpha 1‐antichymotrypsin and alpha 1‐acid glycoprotein as a monitor of inflammatory bowel disease

  1987cited by this paper
• Amyloid protein SAA is associated with high density lipoprotein from human serum.

  1977cited by this paper

• Serum amyloid A: multifaceted roles in inflammation and cellular interactions

  2025cites this paper
• SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer

  2025cites this paper
• Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins

  2024cites this paper
• Oral squamous cell carcinomas drive monocytes into immunosuppressive CD25+CD163+CD206+ macrophages.

  2024cites this paper
• Resistance to chicken amyloid arthropathy is associated with a dysfunctional mutation in serum amyloid A

  2022cites this paper
• Serum amyloid A protein in cancer prognosis: a meta-analysis and systematic review

  2021cites this paper
• Systemic inflammation is a determinant of outcomes of CD40 agonist–based therapy in pancreatic cancer patients

  2021cites this paper
• Serum Amyloid A Proteins and Their Impact on Metastasis and Immune Biology in Cancer

  2021influential citation
• The turning away of serum amyloid A biological activities and receptor usage

  2020cites this paper
• Biological Characterization of Commercial Recombinantly Expressed Immunomodulating Proteins Contaminated with Bacterial Products in the Year 2020: The SAA3 Case

  2020cites this paper
• Recombinant Epinephelus lanceolatus serum amyloid A as a feed additive: Effects on immune gene expression and resistance to Vibrio alginolyticus infection in Epinephelus lanceolatus

  2018cites this paper
• Secondary, AA, Amyloidosis.

  2018cites this paper