The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Immunity

• Publication date

  2010-05-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.immuni.2010.05.005PMID 20510871
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates.

  2009influential reference
• In Vivo Analysis of Dendritic Cell Development and Homeostasis

  2009cited by this paper
• Dendritic cell homeostasis.

  2009influential reference
• The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis.

  2009influential reference
• FMS-like tyrosine kinase 3 is required for dendritic cell development in peripheral lymphoid tissues

  2008cited by this paper
• Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors.

  2007influential reference
• Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.

  2007influential reference
• Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

  2007influential reference
• Development of dendritic-cell lineages.

  2007cited by this paper
• Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?

  2007cited by this paper
• Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

  2007influential reference
• Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.

  2007cited by this paper
• Steady-state and inflammatory dendritic-cell development

  2007cited by this paper
• Transient Notch signaling induces NK cell potential in Pax5‐deficient pro‐B cells

  2006cited by this paper
• Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon–producing and dendritic cell development

  2006cited by this paper
• Polycomb complexes repress developmental regulators in murine embryonic stem cells

  2006cited by this paper
• Early hematopoietic lineage restrictions directed by Ikaros

  2006cited by this paper
• Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment.

  2006influential reference
• Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors.

  2006influential reference
• Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

  2005influential reference
• Faculty Opinions recommendation of Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate.

  2005cited by this paper
• PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch

  2005cited by this paper
• Visualizing PU.1 activity during hematopoiesis.

  2005influential reference
• Cutting Edge: Generation of Splenic CD8+ and CD8− Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures1

  2005influential reference
• PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

  2005influential reference
• Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

  2005influential reference
• Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors

  2005influential reference
• The development of functional B lymphocytes in conditional PU.1 knock-out mice.

  2005cited by this paper
• Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

  2004influential reference
• Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

  2003influential reference
• Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo

  2003influential reference
• The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid Predendritic Cells Are within the Bone Marrow Hemopoietic Precursors Expressing Flt3

  2003influential reference
• Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.

  2002cited by this paper
• Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage.

  2002cited by this paper
• Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool.

  2002influential reference
• PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.

  2002cited by this paper
• Dendritic cell potentials of early lymphoid and myeloid progenitors.

  2001influential reference
• Development of thymic and splenic dendritic cell populations from different hemopoietic precursors.

  2001cited by this paper
• Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells.

  2000cited by this paper
• PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells.

  2000influential reference
• CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen1

  2000cited by this paper
• Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

  2000cited by this paper
• Transcription Factor PU.1 Is Necessary for Development of Thymic and Myeloid Progenitor-Derived Dendritic Cells1

  2000influential reference
• Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

  1999cited by this paper
• Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

  1999cited by this paper
• Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival.

  1999cited by this paper
• PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.

  1998cited by this paper
• Transcription factors, normal myeloid development, and leukemia.

  1997cited by this paper
• Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified

  1996cited by this paper
• Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

  1996cited by this paper
• Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors.

  1995cited by this paper
• PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene

  1995cited by this paper
• Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

  1994cited by this paper
• Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

  1992cited by this paper

• RORγt+ dendritic cells are a distinct lymphoid-derived lineage.

  2026cites this paper
• A combinatorial transcription factor screening platform for immune cell reprogramming.

  2026cites this paper
• Overview of dendritic cells subsets and their involvement in immune-related pathological disease

  2025cites this paper
• TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells

  2025cites this paper
• One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them.

  2025cites this paper
• Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity.

  2025cites this paper
• Reprogramming tumor cells to fight cancer

  2024cites this paper
• Advances in understanding of dendritic cell in the pathogenesis of acute kidney injury

  2024cites this paper
• Redistribution of PU.1 partner transcription factor RUNX1 binding secures cell survival during leukemogenesis

  2024cites this paper
• Transcription factor-mediated reprogramming to antigen-presenting cells.

  2024cites this paper
• Effector Functions of Dendritic Cells in Cancer: Role of Cytotoxicity and Growth Inhibition.

  2024cites this paper
• The role of dendritic cells in respiratory viral infection

  2024cites this paper
• Multi-layered effects of Panax notoginseng on immune system.

  2024cites this paper
• ETS Transcription Factors in Immune Cells and Immune-Related Diseases

  2024cites this paper
• Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation

  2024cites this paper
• TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription

  2024cites this paper
• Transcriptional regulation of dendritic cell development and function

  2023cites this paper
• Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance

  2023cites this paper
• Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells

  2023cites this paper
• Lin− PU.1dimGATA‐1− defines haematopoietic stem cells with long‐term multilineage reconstitution activity

  2023cites this paper
• DNA selection by the master transcription factor PU.1.

  2023cites this paper
• A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation

  2023cites this paper
• Epigenetic remodeling of the immune landscape in cancer: therapeutic hurdles and opportunities

  2023cites this paper
• Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation

  2022cites this paper
• Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer

  2022cites this paper
• Plasmacytoid Dendritic Cells, a Novel Target in Myeloid Neoplasms

  2022cites this paper
• Regulation of pDC fate determination by histone deacetylase 3

  2022cites this paper
• It Takes a Village: The Multifaceted Immune Response to Mycobacterium tuberculosis Infection and Vaccine-Induced Immunity

  2022cites this paper
• Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

  2022cites this paper
• Dendritic Cell-Based Immunotherapy in Hot and Cold Tumors

  2022influential citation
• Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy.

  2021cites this paper
• Role of GATA2 in Human NK Cell Development.

  2021cites this paper
• The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells

  2021cites this paper
• Direct oral penicillin challenge for penicillin allergy delabeling as a health services intervention: A multicenter cohort study

  2021cites this paper
• Dendritic cell Flt3 – regulation, roles and repercussions for immunotherapy

  2021cites this paper
• Adipocyte-Specific Ablation of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome in Aging Mice

  2021cites this paper
• Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients

  2021cites this paper
• Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT

  2021cites this paper
• B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors

  2021cites this paper
• Prostaglandin E2 Regulates Bipotent Monocyte-Dendritic Progenitor Cell Lineage-Commitment

  2021cites this paper
• Unboxing dendritic cells: Tales of multi‐faceted biology and function

  2021cites this paper
• The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

  2021cites this paper
• Transcription factors regulate early T cell development via redeployment of other factors

  2021cites this paper
• Regulation of hematopoiesis and B-lymphocyte development by histone deubiquitinases

  2021cites this paper
• Immunomodulatory Role and Therapeutic Potential of Non-Coding RNAs Mediated by Dendritic Cells in Autoimmune and Immune Tolerance-Related Diseases

  2021cites this paper
• Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors.

  2020cites this paper
• Dual Roles of PU.1 in the Expression of PD-L2: Direct Transactivation with IRF4 and Indirect Epigenetic Regulation

  2020cites this paper
• Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment.

  2020cites this paper
• Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma

  2020cites this paper
• ncRNAs in Type-2 Immunity

  2020cites this paper
• TNFα Rescues Dendritic Cell Development in Hematopoietic Stem and Progenitor Cells Lacking C/EBPα

  2020cites this paper
• Transcription factor PU.1 and immune cell differentiation (Review).

  2020cites this paper
• High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.

  2020influential citation
• Epigenetic aspects of DC development and differentiation.

  2020cites this paper
• The TLR4-MyD88 Signaling Axis Regulates Lung Monocyte Differentiation Pathways in Response to Streptococcus pneumoniae

  2020cites this paper
• Bi‐stability of the master gene regulatory network of the common dendritic precursor cell: Implications for cell differentiation

  2020cites this paper
• FLT3 Ligand Is Dispensable for the Final Stage of Type 1 Conventional Dendritic Cell Differentiation

  2020cites this paper
• How transcription factors drive choice of the T cell fate

  2020cites this paper
• Transcriptional Networks Driving Dendritic Cell Differentiation and Function.

  2020cites this paper
• Comparison of the PU.1 transcriptional regulome and interactome in human and mouse inflammatory dendritic cells

  2020cites this paper
• How transcription factors drive choice of the T cell fate

  2020cites this paper
• Plasmacytoid dendritic cells in the eye.

  2020cites this paper
• Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation

  2019cites this paper
• Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer.

  2019cites this paper
• Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC‐SCRIPT

  2019cites this paper
• Dynamic control of the T-cell specification gene regulatory network.

  2019cites this paper
• Understanding and Modulating Immunity With Cell Reprogramming

  2019cites this paper
• Origin and development of classical dendritic cells.

  2019cites this paper
• Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View

  2019cites this paper
• Models of dendritic cell development correlate ontogeny with function.

  2019cites this paper
• Modulation of FLT3 through decitabine-activated C/EBPa-PU.1 signal pathway in FLT3-ITD positive cells.

  2019cites this paper
• 9-O-acetyl sialic acid levels identify committed progenitors of plasmacytoid dendritic cells.

  2019cites this paper
• Dendritic cell subsets and locations.

  2019cites this paper
• Plasmacytoid Dendritic Cells: Development, Regulation, and Function

  2019cites this paper
• LncRNA PU.1 AS regulates arsenic-induced lipid metabolism through EZH2/Sirt6/SREBP-1c pathway.

  2019cites this paper
• Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development

  2019cites this paper
• On the Way to Become a Natural Killer Cell

  2019cites this paper
• Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

  2018cites this paper
• The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell–Specific Expression of RALDH2

  2018cites this paper
• Human dendritic cell subsets: an update

  2018cites this paper
• Cytokines, Transcription Factors, and the Initiation of T-Cell Development.

  2018cites this paper
• Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

  2018cites this paper
• Identification and isolation of five developmental stages in GM-CSF-stimulated murine bone marrow culture.

  2018cites this paper
• Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

  2018cites this paper
• PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

  2018cites this paper
• Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development

  2018cites this paper
• Homeostatic control of dendritic cell numbers and differentiation

  2018cites this paper
• Niche signals and transcription factors involved in tissue-resident macrophage development

  2018cites this paper
• Molecular Regulation of Differentiation in Early B-Lymphocyte Development

  2018cites this paper
• “Double‐duty” conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells

  2018cites this paper
• MicroRNAs and immunity in periodontal health and disease

  2018cites this paper
• Role of PU.1 Expression as an Inflammatory Marker in Experimental Autoimmune Uveoretinitis

  2018cites this paper
• MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1

  2017cites this paper
• The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c

  2017cites this paper
• Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling

  2017cites this paper
• The Impact of Id2 on Langerhans Cell Development

  2017influential citation
• The ontogeny of inflammatory macrophages and monocyte-derived dendritic cells

  2017cites this paper
• Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

  2017cites this paper
• Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression.

  2017cites this paper
• Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature

  2017cites this paper