Y-box factor YB1 controls p53 apoptotic function

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Oncogene

• Publication date

  2005-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1208998PMID 16158057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression

  2000influential reference
• Regulation of the human fas promoter by YB-1, Puralpha and AP-1 transcription factors.

  2000cited by this paper
• Quantifying adenoviral titers by spectrophotometry.

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• p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

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• The p53 pathway

  1999cited by this paper
• Activities of cold-shock domain proteins in translation control.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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• Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53.

  1999cited by this paper
• A survey of 178 NF-Y binding CCAAT boxes.

  1998cited by this paper
• Gene regulation by Y-box proteins: coupling control of transcription and translation.

  1998cited by this paper
• Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma.

  1998cited by this paper
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  1998cited by this paper
• Nuclear translocation of the Y‐box binding protein by ultraviolet irradiation

  1997cited by this paper
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  1997cited by this paper
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• A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins.

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• Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

  1995cited by this paper
• Structural and functional properties of the evolutionarily ancient Y‐box family of nucleic acid binding proteins

  1994cited by this paper
• Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

  1994cited by this paper
• Involvement of a DNA binding protein, MDR-NF1/YB-1, in human MDR1 gene expression by actinomycin D.

  1994cited by this paper
• Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation.

  1993cited by this paper
• Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.

  1990cited by this paper
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  1988cited by this paper

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• Y-box binding protein 1--a prognostic marker and target in tumour therapy.

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  2009cites this paper
• JCB_200810084 797..810

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