Gender Differences in Cardioprotection against Ischemia/Reperfusion Injury in Adult Rat Hearts: Focus on Akt and Protein Kinase C Signaling

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/JPET.105.090803PMID 16099927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Prenatal cocaine exposure increases heart susceptibility to ischaemia–reperfusion injury in adult male but not female rats

  2005cited by this paper
• Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury.

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• Effect of prenatal hypoxia on heat stress-mediated cardioprotection in adult rat heart.

  2004cited by this paper
• Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C.

  2004cited by this paper
• Postconditioning: A Form of “Modified Reperfusion” Protects the Myocardium by Activating the Phosphatidylinositol 3-Kinase–Akt Pathway

  2004cited by this paper
• Protein kinase C and myocardial calcium handling during ischemia and reperfusion: lessons learned using Rhod-2 spectrofluorometry.

  2004cited by this paper
• Preservation of Base-line Hemodynamic Function and Loss of Inducible Cardioprotection in Adult Mice Lacking Protein Kinase Cϵ*

  2004cited by this paper
• Adrenomedullin Infusion Attenuates Myocardial Ischemia/Reperfusion Injury Through the Phosphatidylinositol 3-Kinase/Akt-Dependent Pathway

  2004cited by this paper
• Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits.

  2003cited by this paper
• Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery

  2003cited by this paper
• Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS.

  2003cited by this paper
• Sex is a potent modifier of the cardiovascular system.

  2003cited by this paper
• Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery.

  2003cited by this paper
• Effect of Fetal Hypoxia on Heart Susceptibility to Ischemia and Reperfusion Injury in the Adult Rat

  2003cited by this paper
• Cross-regulation of Novel Protein Kinase C (PKC) Isoform Function in Cardiomyocytes

  2003cited by this paper
• Gender differences in sarcoplasmic reticulum calcium loading after isoproterenol.

  2003cited by this paper
• Impact of estrogen replacement on ventricular myocyte contractile function and protein kinase B/Akt activation.

  2003cited by this paper
• Gender differences in the expression of heat shock proteins: the effect of estrogen.

  2003cited by this paper
• Exercise Improves Postischemic Cardiac Function in Males but Not Females: Consequences of a Novel Sex-Specific Heat Shock Protein 70 Response

  2002cited by this paper
• Gender-specific difference in cardiac ATP-sensitive K(+) channels.

  2001cited by this paper
• Myocardial Akt Activation and Gender: Increased Nuclear Activity in Females Versus Males

  2001cited by this paper
• Heat shock proteins and cardiovascular pathophysiology.

  2001cited by this paper
• Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity.

  2001cited by this paper
• Akt like a woman: gender differences in susceptibility to cardiovascular disease.

  2001cited by this paper
• Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function

  2001cited by this paper
• Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo

  2001cited by this paper
• Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.

  2000cited by this paper
• Multiple pathways control protein kinase C phosphorylation

  2000cited by this paper
• Ischemic Preconditioning Activates Phosphatidylinositol-3-Kinase Upstream of Protein Kinase C

  2000cited by this paper
• Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

  2000cited by this paper
• Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats.

  2000cited by this paper
• Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

  2000cited by this paper
• Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery.

  1999cited by this paper
• Apoptosis in cardiac disease.

  1999cited by this paper
• Apoptosis: basic mechanisms and implications for cardiovascular disease.

  1998cited by this paper
• Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor.

  1998cited by this paper
• Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

  1993cited by this paper
• Chelerythrine is a potent and specific inhibitor of protein kinase C.

  1990cited by this paper

• Gender- and sex-dependent variations in heart failure and cardiomyopathies: a review of the literature.

  2026cites this paper
• Sex differences in mitochondrial Ca2+ during ischemia/reperfusion injury: A role for S-Nitrosylation.

  2026cites this paper
• Estrogen Alleviates Myocardial Ischemia–Reperfusion Injury by Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

  2025cites this paper
• Postmortem Immunohistochemical Findings in Early Acute Myocardial Infarction: A Systematic Review

  2024cites this paper
• Effect of long-term inorganic nitrate administration on myocardial ischemia-reperfusion injury in ovariectomized rats

  2024cites this paper
• Sex Differences in Cardiac Tolerance to Oxygen Deprivation - 40 Years of Cardiovascular Research.

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• Perfusate Biomarkers of DCD Cardiac Graft Quality Identified With Proteomics: Studies in an Isolated Rat Heart Model

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• Age and sex-based impacts of maternal iron deficiency on offspring’s cognitive function and anemia: A systematic review

  2024cites this paper
• Sex-Specific Effects of Estradiol and Progesterone in Ischemic Kidney Injury

  2024cites this paper
• Effect of tanshinone IIA for myocardial ischemia/reperfusion injury in animal model: preclinical evidence and possible mechanisms

  2023cites this paper
• 16α-OHE1, a novel oestrogen metabolite, attenuates dysfunction of left ventricle contractility via regulation of autophagy after myocardial ischemia and reperfusion.

  2023cites this paper
• Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives

  2023cites this paper
• Rapamycin treatment unmasks a sex‐specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel

  2023cites this paper
• Sex-Specific Effects of Prenatal Hypoxia on the Cardiac Endothelin System in Adult Offspring.

  2022cites this paper
• Hypoxia Marker Carbonic Anhydrase IX Is Present in Abdominal Aortic Aneurysm Tissue and Plasma

  2022cites this paper
• Evaluation of the causes of sex disparity in heart failure trials

  2022cites this paper
• Differential Effects of Reperfusion on Cardiac Mitochondrial Subpopulations in a Preclinical Porcine Model of Acute Myocardial Infarction

  2022cites this paper
• Role of caveolin-eNOS platform and mitochondrial ATP-sensitive potassium channel in abrogated cardioprotective effect of ischemic preconditioning in postmenopausal women

  2022cites this paper
• PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications.

  2022cites this paper
• Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning

  2022cites this paper
• (Sex differences in cardiac tolerance to ischemia-reperfusion injury - the role of mitochondria)

  2021cites this paper
• Placental Treatment Improves Cardiac Tolerance to Ischemia/Reperfusion Insult in Adult Male and Female Offspring Exposed to Prenatal Hypoxia.

  2021cites this paper
• Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia

  2021cites this paper
• Cardioprotective effects of severe calorie restriction from birth in adult ovariectomized rats.

  2021cites this paper
• Pohlavní rozdíly v citlivosti srdečního svalu k ischemicko- -reperfuznnímu poškození - úloha mitochondrií

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• Influence of Ischemia-reperfusion Injury on Endothelial Function in Men and Women with Similar Serum Estradiol Concentrations.

  2021cites this paper
• Influence of Intrinsic Aerobic Exercise Capacity and Sex on Cardiac Injury Following Acute Myocardial Ischemia and Reperfusion

  2021cites this paper
• Caloric restriction in heart failure: A systematic review.

  2020cites this paper
• Gender-related differences in treatment and outcome of eCPR-patients.

  2020cites this paper
• Sex Differences in Cardiac Ischemia/Reperfusion Injury

  2020cites this paper
• The Role of Estrogen Receptors in Cardiovascular Disease

  2020cites this paper
• Sex Differences in Contractile Function in Cardiac Hypertrophy and Heart Failure Subsequent to Volume Overload

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Mitochondrial integrity during early reperfusion in an isolated rat heart model of donation after circulatory death-consequences of ischemic duration.

  2019cites this paper
• Sex is no determinant of cardioprotection by ischemic preconditioning in rats, but ischemic/reperfused tissue mass is for remote ischemic preconditioning

  2019cites this paper
• Menopause and Age-Related General Health Risk: A Woman’s Heart Needs Her Hormones

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Inorganic Arsenic Exposure and Sex Dependent Susceptibility to Ischemic Heart Injury

  2018influential citation
• Gestational Hypoxia and Developmental Plasticity.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• The impact of sex and myocardial ischemic preconditioning on immunohistochemical markers of acute myocardial infarction

  2018cites this paper
• Gendered Innovations in the Study of Cardiovascular Diseases.

  2018cites this paper
• Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system

  2017cites this paper
• Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Mechanistic Pathways of Sex Differences in Cardiovascular Disease.

  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Sex-dependent effects of sleep deprivation on myocardial sensitivity to ischemic injury

  2016cites this paper
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  2016cites this paper
• Prenatal methamphetamine differentially alters myocardial sensitivity to ischemic injury in male and female adult hearts.

  2016cites this paper
• Molecular and cellular interactions between mother and fetus. Pregnancy as a rejuvenating factor

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• Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity.

  2016cites this paper
• JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.

  2016cites this paper
• Improved renal ischemia tolerance in females influences kidney transplantation outcomes.

  2016cites this paper
• Breaking Female Hearts: The Gender Gap in Cardiovascular Research

  2016cites this paper
• Sex and Gender Differences in Cardiovascular Disease

  2016cites this paper
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  2016cites this paper
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  2015influential citation
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• The expression of Akt kinase in the heart ventricles under hypoxic preconditioning and myocardial remodeling

  2014cites this paper
• Role of androgens in sex differences in cardiac damage during myocardial infarction.

  2014cites this paper
• [The expression of Akt kinase in the heart ventricles under hypoxic preconditioning and myocardial remodeling].

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Sex and sex hormones in cardiac stress--mechanistic insights.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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