K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neuron

• Publication date

  2008-05-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2008.03.003PMID 18466749PMCID PMC2730466
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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• Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2.

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• Threshold firing frequency-current relationships of neurons in rat somatosensory cortex: type 1 and type 2 dynamics.

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• Fast-spike interneurons and feedforward inhibition in awake sensory neocortex.

  2003influential reference
• Two dynamically distinct inhibitory networks in layer 4 of the neocortex.

  2003cited by this paper
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  2001cited by this paper
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  2000influential reference
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  2000influential reference
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  1999influential reference
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  1999cited by this paper
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• GABAergic cell subtypes and their synaptic connections in rat frontal cortex.

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  1995cited by this paper
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  1994influential reference
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• Classification of Cortical Neurons

  1991cited by this paper
• Parvalbumin-immunoreactive neurons in the rat neostriatum: a light and electron microscopic study.

  1990cited by this paper
• Intrinsic firing patterns of diverse neocortical neurons.

  1990cited by this paper
• Temporal integration by a slowly inactivating K+ current in hippocampal neurons

  1988cited by this paper
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  1985influential reference
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  1978cited by this paper
• Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma

  1971cited by this paper
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  1966cited by this paper

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