Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Current Opinion in Rheumatology

• Publication date

  1999-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00002281-199905000-00009PMID 10328580
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Influence of interleukin-1β, tumour necrosis factor alpha and prostaglandin E2 on chondrogenesis and cartilage matrix breakdown in vitro

  2004cited by this paper
• Detection of COX-1 and COX-2 isoforms in synovial fluid cells from inflammatory joint diseases.

  1998cited by this paper
• Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation.

  1998cited by this paper
• The role of nitric oxide in articular cartilage breakdown in osteoarthritis.

  1998cited by this paper
• Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis.

  1998cited by this paper
• Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases.

  1998cited by this paper
• Cyclooxygenases 1 and 2.

  1998cited by this paper
• Exacerbated transplant arteriosclerosis in inducible nitric oxide-deficient mice.

  1998cited by this paper
• The role of nitric oxide in inflammation and immunity.

  1998cited by this paper
• Compensatory Prostaglandin E2 Biosynthesis in Cyclooxygenase 1 or 2 Null Cells

  1998cited by this paper
• The Effects of Cyclooxygenase 2 Inhibitors on Cartilage Erosion and Bone Loss in a Model of Mycobacterium tuberculosis-Induced Monoarticular Arthritis in the Rat

  1998cited by this paper
• Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase.

  1998cited by this paper
• Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects.

  1998cited by this paper
• Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2).

  1998cited by this paper
• Regulation of nitric oxide production by salicylates and tenidap in human OA-affected cartilage, rat chondrosarcomas and bovine chondrocytes.

  1998cited by this paper
• Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation

  1998cited by this paper
• Inducible nitric oxide synthase: what difference does it make?

  1997cited by this paper
• Nitric oxide production by superficial and deep articular chondrocytes.

  1997cited by this paper
• Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

  1997cited by this paper
• Detection of interleukin-1 in the cartilage of patients with osteoarthritis: a possible autocrine/paracrine role in pathogenesis.

  1997cited by this paper
• Post‐transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines

  1997cited by this paper
• Nitric oxide and cardiovascular disease.

  1997cited by this paper
• Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis.

  1997cited by this paper
• The vascular biology of nitric oxide and its role in atherogenesis.

  1996cited by this paper
• Prostaglandin E2 stimulates incorporation of proline into collagenase digestible proteins in human articular chondrocytes: identification of an effector autocrine loop involving insulin-like growth factor I.

  1996cited by this paper
• A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.

  1996cited by this paper
• Effects of prostaglandins on deoxyribonucleic acid and aggrecan synthesis in the RCJ 3.1C5.18 chondrocyte cell line: role of second messengers.

  1996cited by this paper
• Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo

  1996cited by this paper
• Inducible cyclooxygenase and nitric oxide synthase.

  1995cited by this paper
• IL-1-induced nitric oxide inhibits chondrocyte proliferation via PGE2.

  1995cited by this paper
• The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up-regulated neuronal nitric oxide synthase

  1995cited by this paper
• The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase.

  1995cited by this paper
• Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

  1995cited by this paper
• Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

  1995cited by this paper
• Differential effects of interleukin-1 alpha and beta on the arachidonic acid cascade in human synovial cells and chondrocytes in culture.

  1993cited by this paper
• [Leukotriene B4, leukotriene C4 and prostaglandin E2 in the serum, synovial fluid and synovium in patients with rheumatoid arthritis].

  1989cited by this paper

• Alantolactone: structural enhancements and therapeutic insights for cancer and inflammation.

  2025cites this paper
• Anti-arthritis Effect of Anti-chitinase-3-like 1 Antibody Through Inhibition of MMP3

  2025cites this paper
• Synergistic therapeutic effect of parecoxib and ilomastat combination in osteoarthritis via inhibition of IL-17/PI3K/AKT/NF-κB activity.

  2025cites this paper
• Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects

  2024cites this paper
• Nuciferine inhibits TLR4/NF-κB/MAPK signaling axis and alleviates adjuvant-induced arthritis in rats.

  2024cites this paper
• Characteristic inflammatory biomarkers in an equine model of persistent synovitis induced by the intra-articular administration of monoiodoacetic acid.

  2023cites this paper
• Probiotic Properties of Loigolactobacillus coryniformis NA-3 and In Vitro Comparative Evaluation of Live and Heat-Killed Cells for Antioxidant, Anticancer and Immunoregulatory Activities

  2023cites this paper
• Nitric oxide scavengers based on o-phenylenediamine for the treatment of rheumatoid arthritis.

  2023cites this paper
• Polydatin inhibits IL-1β-mediated chondrocyte inflammation and ameliorates cartilage degradation: Involvement of the NF-κB and Wnt/β-catenin pathways.

  2022cites this paper
• Dynamics of local gene regulations in synovial fluid leukocytes from horses with lipopolysaccharide-induced arthritis.

  2021cites this paper
• Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats

  2021cites this paper
• NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway

  2021influential citation
• Fatty Acids and Oxylipins in Osteoarthritis and Rheumatoid Arthritis—a Complex Field with Significant Potential for Future Treatments

  2021cites this paper
• Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1β-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-κB and MAPKs signaling pathways and inducing apoptosis.

  2021cites this paper
• Hepatoprotective Activity of Melittin on Isoniazid and Rifampicin Induced Liver Damage in Male Albino Rats

  2020cites this paper
• Anti-inflammatory Activity of Standardized Fraction from Inula helenium L. via Suppression of NF-κB Pathway in RAW 264.7 Cells

  2019cites this paper
• Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE2 pathway

  2019cites this paper
• Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats.

  2019cites this paper
• Humulus japonicus extract ameliorates collagen-induced arthritis in mice through regulation of overall articular inflammation

  2019cites this paper
• Effect of ethanol and aqueous extracts of seed pod of Copaifera salikounda (Heckel) on complete Freund's adjuvant-induced rheumatoid arthritis in rats.

  2019cites this paper
• Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice

  2018cites this paper
• Anticancer Activity of Toxins from Bee and Snake Venom—An Overview on Ovarian Cancer

  2018cites this paper
• Inhibitory effects on the production of inflammatory mediators and reactive oxygen species by Mori folium in lipopolysaccharide-stimulated macrophages and zebrafish.

  2017cites this paper
• New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla

  2017cites this paper
• Do Nitric Oxide Synthases Enzyme Inhibitors Affect Chondrocyte Activity?

  2017cites this paper
• An ethanol extract of Aster yomena (Kitam.) Honda inhibits lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages.

  2017cites this paper
• Effect of lipoic acid on paraoxonase-1 and paraoxonase-3 protein levels, mRNA expression and arylesterase activity in liver hepatoma cells.

  2017cites this paper
• Anti-inflammatory effects of Daehwangmokdantang, a traditional herbal formulation, in lipopolysaccharide-stimulated RAW 264.7 macrophages

  2017cites this paper
• Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

  2017cites this paper
• Fucoidan inhibits lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and zebrafish larvae

  2017cites this paper
• Anethole reduces inflammation and joint damage in rats with adjuvant-induced arthritis

  2017cites this paper
• THE EVOLUTION OF CHONDROITIN SULFATE

  2016cites this paper
• Aortic VCAM‐1: an early marker of vascular inflammation in collagen‐induced arthritis

  2016cites this paper
• Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity.

  2016cites this paper
• Megastigmane Glycosides from Docynia indica and Their Anti‐inflammatory Activities

  2016cites this paper
• Regulation of lipocalin prostaglandin-D synthase expression by interleukin-1β in human chondrocytes

  2016cites this paper
• In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuricae

  2016cites this paper
• A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage

  2016cites this paper
• Tirucallane Glycoside from the Leaves of Antidesma bunius and Inhibitory NO Production in BV2 Cells and RAW264.7 Macrophages

  2016cites this paper
• BEST PRACTICE PROGRAMME IN THE STANDARDISATION OF TRADITIONAL MEDICINES: EVALUATION OF AN IMMUNE BOOSTER FORMULATED BY TRADITIONAL HEALERS OF THE VAAL TRIANGLE, SOUTH AFRICA Pinkoane,

  2016cites this paper
• Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes.

  2016cites this paper
• Steroidal Glucosides from the Rhizomes of Tacca Chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells

  2016cites this paper
• Impact of camel whey protein on the impaired immune response in heat stressed mouse model View project

  2015cites this paper
• Gallic acid can play a chondroprotective role against AGE-induced osteoarthritis progression

  2015cites this paper
• PROPOLIS AND BEE VENOM IN DIABETIC WOUNDS; A POTENTIAL APPROACH THAT WARRANTS CLINICAL INVESTIGATION

  2015cites this paper
• Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice

  2015cites this paper
• Role of integrins and their ligands in osteoarthritic cartilage

  2015cites this paper
• Immune system involvement in metal hip implant failure

  2015cites this paper
• Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis.

  2014cites this paper
• Comparisons of Anti-inflammatory Activity of Crocodile ( Crocodylus siamensis ) Blood Extract

  2014cites this paper
• Tanzawaic acid derivatives from a marine isolate of Penicillium sp. (SF-6013) with anti-inflammatory and PTP1B inhibitory activities.

  2014cites this paper
• Genomic Analysis and Differential Expression of HMG and S100A Family in Human Arthritis: Upregulated Expression of Chemokines, IL-8 and Nitric Oxide by HMGB1

  2014influential citation
• and IL-10 in Human Monocytes CD40-Induced Prostanoid Synthesis by IL-4 Novel Regulatory Mechanisms of

  2013cites this paper
• HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons

  2013cites this paper
• SKLB023 Blocks Joint Inflammation and Cartilage Destruction in Arthritis Models via Suppression of Nuclear Factor-Kappa B Activation in Macrophage

  2013cites this paper
• Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: reversal by celecoxib.

  2013cites this paper
• EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee

  2013influential citation
• NOS‐2 signaling and cancer therapy

  2012cites this paper
• Exploring the Anti-inflammatory and Anti-cancer compounds from the leaves of Acalypha indica

  2012cites this paper
• Single impact cartilage trauma and TNF-α: interactive effects do not increase early cell death and indicate the need for bi-/multidirectional therapeutic approaches.

  2012cites this paper
• Biochemical Mediators Involved in Cartilage Degradation and the Induction of Pain in Osteoarthritis

  2012cites this paper
• Comparative Study of Normal and Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation under Cyclic Mechanical Stretch: Role of Prostaglandin E2

  2012cites this paper
• Development of a latent IL-17 antagonist for targeted therapy of rheumatoid arthritis.

  2012cites this paper
• Dietary polyphenols and mechanisms of osteoarthritis.

  2012cites this paper
• Tumor Necrosis Factor Receptor Pre-Ligand Assembly Domain is an Important Therapeutic Target in Inflammatory Arthritis

  2012cites this paper
• Anti-inflammatory Activity of the Oriental Herb Medicine, Arisaema cum Bile, in LPS-Induced PMA-Differentiated THP-1 Cells

  2012cites this paper
• Retinoic Acid Potentiates Nitric Oxide-Induced Dedifferentiation through the ERK Pathway in Rabbit Articular Chondrocytes

  2011cites this paper
• Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage

  2011cites this paper
• Retinoic Acid Potentiates Nitric Oxide-Induced Dedifferentiation through the ERK Pathway in Rabbit Articular Chondrocytes

  2011cites this paper
• Inhibition of Lipopolysaccharide-Induced iNOS, COX- 2, and TNF-α Expression by Aqueous Extract of Orixa Japonica in RAW 264.7 Cells via Suppression of NF- k B Activity

  2011cites this paper
• Transduced PEP-1-AMPK inhibits the LPS-induced expression of COX-2 and iNOS in Raw264.7 cells.

  2010cites this paper
• Bee venom reduces atherosclerotic lesion formation via anti-inflammatory mechanism.

  2010cites this paper
• Effects of Low-Intensity Pulsed Ultrasound on the Expression and Activity of Hyaluronan Synthase and Hyaluronidase in IL-1β-Stimulated Synovial Cells

  2010cites this paper
• Inhibition of Delayed-Type Hypersensitivity by Cucurbitacin R through the Curbing of Lymphocyte Proliferation and Cytokine Expression by Means of Nuclear Factor AT Translocation to the Nucleus

  2010cites this paper
• Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs.

  2010cites this paper
• Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes

  2010cites this paper
• COX‐2 and iNOS are critical in advanced glycation end product‐activated chondrocytes in vitro

  2009cites this paper
• Inhibition of LPS-induced nitric oxide production by transduced Tat-arginine deiminase fusion protein in Raw 264.7 cells.

  2009cites this paper
• Activation of MMP-2 as a key event in oxidative stress injury to the heart.

  2009cites this paper
• Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins.

  2009cites this paper
• Differential susceptibility of P‐glycoprotein deficient mice to colitis induction by environmental insults

  2009cites this paper
• Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production.

  2009cites this paper
• Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam.

  2008cites this paper
• Wound healing and anti-inflammatory activities of bee venom-chitosan blend films

  2008cites this paper
• Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability.

  2008cites this paper
• DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS

  2008cites this paper
• Intramammary application of non-methylated-CpG oligodeoxynucleotides (CpG) inhibits both local and systemic mammary carcinogenesis in female BALB/c Her-2/neu transgenic mice.

  2008cites this paper
• Effects of glucosamine and chondroitin sulfate on bovine cartilage explants under long-term culture conditions.

  2007cites this paper
• Evaluation of the suppressive actions of glucosamine on the interleukin-1β-mediated activation of synoviocytes

  2007cites this paper
• Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade.

  2007cites this paper
• Dihydrocucurbitacin B Inhibits Delayed Type Hypersensitivity Reactions by Suppressing Lymphocyte Proliferation

  2007cites this paper
• Measurement of eicosanoids in cancer tissues.

  2007cites this paper
• Methanol extracts of Stewartia koreana inhibit cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) gene expression by blocking NF-kappaB transactivation in LPS-activated RAW 264.7 cells.

  2007cites this paper
• Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression.

  2007cites this paper
• Differential regulation of cyclooxygenase‐2 and inducible nitric oxide synthase by 4‐hydroxynonenal in human osteoarthritic chondrocytes through ATF‐2/CREB‐1 transactivation and concomitant inhibition of NF‐κB signaling cascade

  2007influential citation
• Nitric oxide production in association with osteoarthritis

  2007cites this paper
• Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds.

  2007cites this paper
• Cucurbitacin R Reduces the Inflammation and Bone Damage Associated with Adjuvant Arthritis in Lewis Rats by Suppression of Tumor Necrosis Factor-α in T Lymphocytes and Macrophages

  2007cites this paper
• Synergistic Effect of Nitric Oxide Synthase and Cyclooxygenase Inhibitors on Carrageenan-induced Paw Edema in Rats

  2006cites this paper
• Proteomic modification by nitric oxide.

  2006cites this paper