Angiogenesis blockade as a new therapeutic approach to experimental colitis

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Gut

• Publication date

  2006-12-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/gut.2006.114314PMID 17170016PMCID PMC1954843
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease.

  2006cited by this paper
• TNF-α Blockade Down-Regulates the CD40/CD40L Pathway in the Mucosal Microcirculation: A Novel Anti-Inflammatory Mechanism of Infliximab in Crohn’s Disease1

  2006cited by this paper
• Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours

  2006cited by this paper
• Differential angiogenic regulation of experimental colitis.

  2006cited by this paper
• Role of inflammatory mediators in angiogenesis.

  2005cited by this paper
• Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors

  2004cited by this paper
• Angiogenesis in inflammation.

  2004cited by this paper
• Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung

  2004cited by this paper
• Angiogenesis-Dependent and Independent Phases of Intimal Hyperplasia

  2004cited by this paper
• CXC chemokines: the regulatory link between inflammation and angiogenesis.

  2004cited by this paper
• Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn’s disease and ulcerative colitis

  2004cited by this paper
• Vascular endothelium and immune responses: implications for inflammation and angiogenesis.

  2004cited by this paper
• Impact of Dextran Sulfate Sodium Load on the Severity of Inflammation in Experimental Colitis

  2004cited by this paper
• [Chronic inflammation].

  2004cited by this paper
• Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study

  2004cited by this paper
• Antiangiogenic effects of anti-tumor necrosis factor alpha therapy with infliximab in psoriatic arthritis.

  2004cited by this paper
• Angiogenesis in psoriasis

  2004cited by this paper
• Angiogenesis Therapy Moves beyond Cancer

  2004cited by this paper
• Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis.

  2003cited by this paper
• Inhibition of integrin α5β1 function with a small peptide (ATN‐161) plus continuous 5‐FU infusion reduces colorectal liver metastases and improves survival in mice

  2003cited by this paper
• Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients

  2003cited by this paper
• Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice.

  2003cited by this paper
• Angiogenesis in health and disease

  2003cited by this paper
• Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis.

  2003cited by this paper
• Angiogenesis inhibitors in cancer therapy.

  2003cited by this paper
• Imaging of angiogenesis: from microscope to clinic

  2003cited by this paper
• Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis

  2003cited by this paper
• Allograft arteriosclerosis and immune-driven angiogenesis.

  2003cited by this paper
• α5β1 Integrin Activates an NF-κB-Dependent Program of Gene Expression Important for Angiogenesis and Inflammation

  2002cited by this paper
• Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases

  2002cited by this paper
• Distinct inflammatory mechanisms mediate early versus late colitis in mice.

  2002cited by this paper
• In Vivo Detection of Morphological and Microvascular Changes of the Colon in Association with Colitis Using Fiberoptic Confocal Imaging (FOCI)

  2002cited by this paper
• Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation.

  2002cited by this paper
• Fibroblast Growth Factor-2 Determines Severity of Joint Disease in Adjuvant-Induced Arthritis in Rats

  2002cited by this paper
• Angiogenesis: an expanding universe.

  2002cited by this paper
• Angiogenesis in the pathogenesis of inflammatory joint and lung diseases

  2001cited by this paper
• Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs

  2001cited by this paper
• Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A.

  2000cited by this paper
• The role of angiogenesis in rheumatoid arthritis: recent developments

  2000cited by this paper
• Role of alpha v integrins during angiogenesis.

  2000cited by this paper
• Mechanisms of angiogenesis and arteriogenesis

  2000cited by this paper
• The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development.

  1999cited by this paper
• Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist.

  1999cited by this paper
• Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis.

  1999cited by this paper
• Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice.

  1999cited by this paper
• Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist

  1999cited by this paper
• Chronic inflammation: links with angiogenesis and wound healing.

  1998cited by this paper
• The codependence of angiogenesis and chronic inflammation

  1997cited by this paper
• Tumor angiogenesis and the role of vascular cell integrin alphavbeta3.

  1996cited by this paper
• Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation.

  1996cited by this paper
• Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization

  1996cited by this paper
• Angiogenesis in cancer, vascular, rheumatoid and other disease

  1995cited by this paper
• Requirement of vascular integrin alpha v beta 3 for angiogenesis.

  1994cited by this paper
• Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients

  1992cited by this paper
• [Rheumatoid arthritis].

  1983cited by this paper
• Tumor angiogenesis: therapeutic implications.

  1971cited by this paper
• [On psoriasis].

  1952cited by this paper
• GASTROENTEROLOGY 2006;130:2060–2073 Angiogenesis as a Novel Component of Inflammatory Bowel Disease Pathogenesis

  year unknowncited by this paper

• Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin-Targeted Approach.

  2026cites this paper
• Leucine-rich α-2 glycoprotein 1 (LRG1) during inflammatory complications after allogeneic stem cell transplantation and CAR-T cell therapy

  2025cites this paper
• The eNAMPT-Integrin α5β1 Axis Mediates Neutrophil-Endothelial Cell Interactions Driving Inflammation in Ulcerative Colitis

  2025cites this paper
• In Vivo Assessment of Deep Vascular Patterns in Murine Colitis Using Optoacoustic Mesoscopic Imaging

  2024cites this paper
• Gut-liver axis calibrates intestinal stem cell fitness.

  2024cites this paper
• S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice.

  2024cites this paper
• Gut Microbiota Metabolites: Unveiling Their Role in Inflammatory Bowel Diseases and Fibrosis

  2024cites this paper
• Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation

  2024cites this paper
• Surface‐Engineered Vanadium Carbide MXenzyme for Anti‐Inflammation and Photoenhanced Antitumor Therapy of Colon Diseases

  2023cites this paper
• Contribution of Blood Vessel Activation, Remodeling and Barrier Function to Inflammatory Bowel Diseases

  2023cites this paper
• A temporal classifier predicts histopathology state and parses acute-chronic phasing in inflammatory bowel disease patients

  2023cites this paper
• Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier.

  2023cites this paper
• Pathological mechanism and targeted drugs of ulcerative colitis: A review

  2023cites this paper
• Therapeutic effects of Zhuling Jianpi capsule on experimental ulcerative colitis and characterization of its chemical constituents and metabolomics using UHPLC-Q-TOF-MS

  2023cites this paper
• Involvement of integrin-activating peptides derived from tenascin-C in colon cancer progression

  2021cites this paper
• The future of precision medicine to predict outcomes and control tissue remodeling in inflammatory bowel disease.

  2021cites this paper
• The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease

  2021cites this paper
• Role of mesenteric component in Crohn’s disease: A friend or foe?

  2021cites this paper
• Soluble ligands as drug targets for treatment of inflammatory bowel disease.

  2021cites this paper
• Vascular Patterning as Integrative Readout of Complex Molecular and Physiological Signaling by VESsel GENeration Analysis

  2021cites this paper
• Food Processing, Dysbiosis, Gastrointestinal Inflammatory Diseases, and Antiangiogenic Functional Foods or Beverages.

  2021cites this paper
• ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

  2020cites this paper
• Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway

  2020cites this paper
• Evaluation of protein arginine deiminase-4 inhibitor in TNBS- induced colitis in mice.

  2020cites this paper
• Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn’s Disease Development via the Upregulation of CARD3 Expression

  2020cites this paper
• Experimental and clinical evidence of endothelial dysfunction in inflammatory bowel disease.

  2020cites this paper
• The Endothelium During Allogeneic Stem Cell Transplantation

  2019cites this paper
• Natural Products: Experimental Efficient Agents for Inflammatory Bowel Disease Therapy.

  2019cites this paper
• Endothelial MT1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis

  2019cites this paper
• Antibody-Mediated Delivery of VEGFC Ameliorates Experimental Chronic Colitis.

  2019cites this paper
• Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association

  2018cites this paper
• COMP-angiopoietin-1 ameliorates inflammation-induced lymphangiogenesis in dextran sulfate sodium (DSS)-induced colitis model

  2018cites this paper
• Compositions and Methods for Treating Ischemia

  2018cites this paper
• Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy.

  2018cites this paper
• Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis

  2018cites this paper
• ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

  2017cites this paper
• Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions

  2017cites this paper
• Vascular endothelial growth factor - key mediator of angiogenesis and promising therapeutical target in ulcerative colitis.

  2017cites this paper
• Hypoxia and inflammatory bowel disease.

  2017cites this paper
• Hypoxia-inducible factor-1α: a promising therapeutic target for autoimmune diseases

  2017cites this paper
• Leishmania major Infection–Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease

  2016cites this paper
• Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis

  2016cites this paper
• Placental growth factor enhances angiogenesis in human intestinal microvascular endothelial cells via PI3K/Akt pathway: Potential implications of inflammation bowel disease.

  2016cites this paper
• Initiation of acute graft-versus-host disease by angiogenesis.

  2016cites this paper
• Murine colitis treated with multitargeted tyrosine kinase inhibitors.

  2016cites this paper
• Effect of Oral Administration of 3,3'-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice.

  2016cites this paper
• Angiogenesis and Vascular Endothelial Growth Factor-A Expression Associated with Inflammation in Pediatric Crohn’s Disease

  2016cites this paper
• Immunopathogenesis of IBD: current state of the art

  2016cites this paper
• FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities.

  2016cites this paper
• MRI texture analysis parameters of contrast-enhanced T1-weighted images of Crohn’s disease differ according to the presence or absence of histological markers of hypoxia and angiogenesis

  2016cites this paper
• Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

  2015cites this paper
• Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice

  2015cites this paper
• Downregulation of FoxC2 Increased Susceptibility to Experimental Colitis: Influence of Lymphatic Drainage Function?

  2015cites this paper
• Long-term risk of mesenteric ischemia in patients with inflammatory bowel disease: a 13-year nationwide cohort study in an Asian population.

  2015cites this paper
• Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells.

  2015cites this paper
• Mouse strain influences angiogenic response to dextran sodium sulfate-induced colitis.

  2014cites this paper
• Severe exacerbation of Crohn's disease during sunitinib treatment.

  2014cites this paper
• VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease.

  2014cites this paper
• Inhibition of Endothelial Slit2/Robo1 Signaling by Thalidomide Restrains Angiogenesis by Blocking the PI3K/Akt Pathway

  2014cites this paper
• Targeting endothelial CD146 attenuates colitis and prevents colitis-associated carcinogenesis.

  2014cites this paper
• The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

  2014cites this paper
• Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease

  2013cites this paper
• MicroRNA-21 Knockout Improve the Survival Rate in DSS Induced Fatal Colitis through Protecting against Inflammation and Tissue Injury

  2013cites this paper
• Novel pharmacologic approaches to the prevention and treatment of ulcerative colitis.

  2013cites this paper
• VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164b therapy

  2013cites this paper
• Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation

  2013influential citation
• Gut sterilization in experimental colitis leukocyte mediated colon injury, and effects on angiogenesis/lymphangiogenesis

  2013cites this paper
• Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.

  2013cites this paper
• Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis.

  2013cites this paper
• Nilotinib-mediated mucosal healing in a rat model of colitis.

  2013cites this paper
• The endothelium in graft-versus-host disease and graft-versus-leukemia

  2013cites this paper
• Thrombospondin and VEGF-R: Is There a Correlation in Inflammatory Bowel Disease?

  2013cites this paper
• Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis

  2013cites this paper
• STUDIES ON THE T CELL SUPPRESSIVE AND ANTI-ANGIOGENIC ACTIVITIES OF THE DIETARY PHYTOCHEMICAL PIPERINE

  2013cites this paper
• Pretreatment with anti-VEGF therapy may exacerbate inflammation in experimental acute colitis.

  2012cites this paper
• 1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression of NF-κB activation and IL-8 induction.

  2012cites this paper
• Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses

  2011cites this paper
• The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation.

  2011cites this paper
• Corticosteroids Modulate Angiogenic Soluble Factors in Ulcerative Colitis Patients

  2011cites this paper
• Extraluminal factors contributing to inflammatory bowel disease.

  2011cites this paper
• Temporal genomewide expression profiling of DSS colitis reveals novel inflammatory and angiogenesis genes similar to ulcerative colitis.

  2011cites this paper
• Expression, localization and systemic concentration of vascular endothelial growth factor (VEGF) and its receptors in patients with ulcerative colitis.

  2011cites this paper
• Role of the endothelium in inflammatory bowel diseases.

  2011cites this paper
• New cell therapy using bone marrow-derived stem cells/endothelial progenitor cells to accelerate neovascularization in healing of experimental ulcerative colitis.

  2011cites this paper
• Infliximab Therapy Inhibits Inflammation-Induced Angiogenesis in the Mucosa of Patients With Crohn's Disease

  2011cites this paper
• Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.

  2011cites this paper
• Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: ‘brothers in arms’

  2011cites this paper
• Endotheliale Progenitorzellen und Natürliche Killerzellen bei Allogener Stammzelltransplantation und Tumor-Immuntherapie

  2010cites this paper
• Alpha-, gamma- and delta-tocopherols reduce inflammatory angiogenesis in human microvascular endothelial cells.

  2010cites this paper
• Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury

  2010cites this paper
• Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.

  2010cites this paper
• Fibrosis in the GI Tract: Pathophysiology, Diagnosis and Treatment Options

  2010cites this paper
• Gastrointestinal , Hepatobiliary and Pancreatic Pathology Substance P-Mediated Expression of the Pro-Angiogenic Factor CCN 1 Modulates the Course of Colitis

  2010cites this paper
• Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth.

  2010cites this paper
• Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease

  2010cites this paper
• Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin.

  2010cites this paper
• Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease.

  2010cites this paper
• Thalidomide inhibits inflammatory and angiogenic activation of human intestinal microvascular endothelial cells (HIMEC).

  2010cites this paper
• Technical Advance: Function and efficacy of an α4‐integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis

  2010cites this paper
• Integrin Signaling 3 β v α Modulating Osteopontin-Dependent in Murine Experimental Colitis by MFG-E 8 Attenuates Intestinal Inflammation and

  2009cites this paper