Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Journal of Clinical Investigation

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI25843PMID 16453022PMCID PMC1359048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000cited by this paper
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  1999cited by this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• [Beta-amyloidopathy as a manifestation of proteinopathy in age-related macular degeneration].

  2015cites this paper
• [Beta-amyloidopathy as a manifestation of proteinopathy in age-related macular degeneration].

  2015cites this paper
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  2015cites this paper