Recent Advances in the Discovery and Development of Marine Microbial Natural Products

Marine microbial natural products (MMNPs) have attracted increasing attention from microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists during the last few decades. Numerous studies have indicated that diverse marine microbes appear to have the capacity to produce an impressive array of MMNPs exhibiting a wide variety of biological activities such as antimicrobial, anti-tumor, anti-inflammatory and anti-cardiovascular agents. Marine microorganisms represent an underexplored reservoir for the discovery of MMNPs with unique scaffolds and for exploitation in the pharmaceutical and agricultural industries. This review focuses on MMNPs discovery and development over the past decades, including innovative isolation and culture methods, strategies for discovering novel MMNPs via routine screenings, metagenomics, genomics, combinatorial biosynthesis, and synthetic biology. The potential problems and future directions for exploring MMNPs are also discussed.

• Publication year

  2013

• Venue

  Marine Drugs

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.3390/md11030700PMID 23528949PMCID 3705366
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cultivation of unculturable soil bacteria.

  2012cited by this paper
• Draft Genome Sequence of Marine-Derived Streptomyces sp. Strain AA0539, Isolated from the Yellow Sea, China

  2012cited by this paper
• Synthetic biology triggers new era of antibiotics development.

  2012cited by this paper
• Draft Genome Sequence of the Marine Streptomyces sp. Strain AA1529, Isolated from the Yellow Sea

  2012cited by this paper
• Growing Unculturable Bacteria

  2012cited by this paper
• Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

  2012cited by this paper
• Genetic Screening Strategy for Rapid Access to Polyether Ionophore Producers and Products in Actinomycetes

  2011cited by this paper
• Organization of Intracellular Reactions with Rationally Designed RNA Assemblies

  2011cited by this paper
• Distribution of dTDP-glucose-4,6-dehydratase gene and diversity of potential glycosylated natural products in marine sediment-derived bacteria

  2011influential reference
• Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

  2011cited by this paper
• Genomics-inspired discovery of natural products.

  2011cited by this paper
• Characterization of Streptomyces padanus JAU4234, a Producer of Actinomycin X2, Fungichromin, and a New Polyene Macrolide Antibiotic

  2011cited by this paper
• Investigating the role of native propionyl‐CoA and methylmalonyl‐CoA metabolism on heterologous polyketide production in Escherichia coli

  2010cited by this paper
• Siderophores from neighboring organisms promote the growth of uncultured bacteria.

  2010cited by this paper
• Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

  2010cited by this paper
• Isolation, Phylogenetic Analysis and Anti-infective Activity Screening of Marine Sponge-Associated Actinomycetes

  2010cited by this paper
• Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products

  2010cited by this paper
• The expanding role of marine microbes in pharmaceutical development.

  2010cited by this paper
• Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria.

  2010cited by this paper
• Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules.

  2010cited by this paper
• A preliminary investigation on the growth requirement for monovalent cations, divalent cations and medium ionic strength of marine actinomycete Salinispora

  2010cited by this paper
• Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola

  2010cited by this paper
• Strategies for culture of 'unculturable' bacteria.

  2010cited by this paper
• Bioprospecting microbial natural product libraries from the marine environment for drug discovery

  2010cited by this paper
• Sequence-Based Analysis of Secondary-Metabolite Biosynthesis in Marine Actinobacteria

  2010cited by this paper
• Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster.

  2010cited by this paper
• Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

  2010cited by this paper
• Isolation and characterization of low nucleic acid (LNA)-content bacteria

  2009cited by this paper
• Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicola.

  2009cited by this paper
• Synthetic protein scaffolds provide modular control over metabolic flux

  2009cited by this paper
• Metagenomics: Concept, methodology, ecological inference and recent advances

  2009cited by this paper
• Programming cells by multiplex genome engineering and accelerated evolution

  2009cited by this paper
• Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12

  2009cited by this paper
• Improved culturability of SAR11 strains in dilution-to-extinction culturing from the East Sea, West Pacific Ocean.

  2009cited by this paper
• The Screening of Antimicrobial Bacteria with Diverse Novel Nonribosomal Peptide Synthetase (NRPS) Genes from South China Sea Sponges

  2009cited by this paper
• Natural products from environmental DNA hosted in Ralstonia metallidurans.

  2009cited by this paper
• Cultivation of Fastidious Bacteria by Viability Staining and Micromanipulation in a Soil Substrate Membrane System

  2009cited by this paper
• An in situ method for cultivating microorganisms using a double encapsulation technique.

  2009cited by this paper
• Identification and Manipulation of the Caprazamycin Gene Cluster Lead to New Simplified Liponucleoside Antibiotics and Give Insights into the Biosynthetic Pathway*

  2009cited by this paper
• Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.

  2008cited by this paper
• Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages

  2008cited by this paper
• Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome.

  2008cited by this paper
• Short Peptide Induces an “Uncultivable” Microorganism To Grow In Vitro

  2008cited by this paper
• Growth of Salinispora tropica strains CNB440, CNB476, and NPS21184 in nonsaline, low-sodium media

  2008cited by this paper
• Isolation of uncultivable anaerobic thermophiles of the family Clostridiaceae requiring growth-supporting factors.

  2008cited by this paper
• Cultivating previously uncultured soil bacteria using a soil substrate membrane system

  2008cited by this paper
• Characterization of growth-supporting factors produced by Geobacillus toebii for the commensal thermophile Symbiobacterium toebii.

  2008cited by this paper
• The future of natural products as a source of new antibiotics.

  2007influential reference
• PCR screening reveals unexpected antibiotic biosynthetic potential in Amycolatopsis sp. strain UM16

  2007cited by this paper
• Rare actinomycete bacteria from the shallow water sediments of the Trondheim fjord, Norway: isolation, diversity and biological activity.

  2007cited by this paper
• Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules

  2007cited by this paper
• A Genomic Screening Approach to the Structure‐Guided Identification of Drug Candidates from Natural Sources

  2007cited by this paper
• Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicola.

  2007cited by this paper
• Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.

  2007cited by this paper
• Natural products as sources of new drugs over the last 25 years.

  2007cited by this paper
• Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

  2007influential reference
• Developing a new resource for drug discovery: marine actinomycete bacteria

  2006cited by this paper
• Production of the antimalarial drug precursor artemisinic acid in engineered yeast

  2006cited by this paper
• Combinatorial biosynthesis in symbiotic bacteria

  2006cited by this paper
• New drugs from marine microbes: the tide is turning

  2006cited by this paper
• Catalyzed Reporter Deposition-Fluorescence In Situ Hybridization Allows for Enrichment-Independent Detection of Microcolony-Forming Soil Bacteria

  2006cited by this paper
• Production of isoprenoid pharmaceuticals by engineered microbes

  2006cited by this paper
• Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

  2006cited by this paper
• Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora".

  2006cited by this paper
• Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians

  2006cited by this paper
• Exploring novel bioactive compounds from marine microbes.

  2005cited by this paper
• Culturable marine actinomycete diversity from tropical Pacific Ocean sediments.

  2005cited by this paper
• Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi.

  2005cited by this paper
• Isolation of uncultivated anaerobic thermophiles from compost by supplementing cell extract of Geobacillus toebii in enrichment culture medium

  2005cited by this paper
• Metagenomics and industrial applications

  2005cited by this paper
• Microcolony Cultivation on a Soil Substrate Membrane System Selects for Previously Uncultured Soil Bacteria

  2005cited by this paper
• The metagenomics of soil

  2005cited by this paper
• Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.

  2005cited by this paper
• Bioactive Microbial Metabolites

  2005cited by this paper
• Metagenomics-based drug discovery and marine microbial diversity.

  2005cited by this paper
• Tuning genetic control through promoter engineering.

  2005cited by this paper
• Microbial Diversity in Coastal Subsurface Sediments: a Cultivation Approach Using Various Electron Acceptors and Substrate Gradients

  2005cited by this paper
• Ribosome engineering and secondary metabolite production.

  2004cited by this paper
• New PCR Primers for the Screening of NRPS and PKS-I Systems in Actinomycetes: Detection and Distribution of These Biosynthetic Gene Sequences in Major Taxonomic Groups

  2004cited by this paper
• Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei.

  2004cited by this paper
• The filtration-acclimatization method for isolation of an important fraction of the not readily cultivable bacteria.

  2004cited by this paper
• Application of sucrose‐gradient centrifugation for selective isolation of Nocardia spp. from soil

  2003cited by this paper
• Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

  2003cited by this paper
• Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis

  2003cited by this paper
• Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model

  2003cited by this paper
• Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters.

  2003cited by this paper
• A genomics-guided approach for discovering and expressing cryptic metabolic pathways

  2003cited by this paper
• Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

  2003cited by this paper
• Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

  2002cited by this paper
• A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.

  2002cited by this paper
• Cultivation of the ubiquitous SAR11 marine bacterioplankton clade

  2002cited by this paper
• Isolating "Uncultivable" Microorganisms in Pure Culture in a Simulated Natural Environment

  2002cited by this paper
• Cultivating the uncultured

  2002cited by this paper
• Cyclic AMP and Acyl Homoserine Lactones Increase the Cultivation Efficiency of Heterotrophic Bacteria from the Central Baltic Sea

  2002cited by this paper
• High-Throughput Methods for Culturing Microorganisms in Very-Low-Nutrient Media Yield Diverse New Marine Isolates

  2002cited by this paper
• Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

  2001cited by this paper
• Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites

  2001cited by this paper
• Selective Isolation and Distribution ofSporichthya Strains in Soil

  1999cited by this paper
• Phylogenetic identification and in situ detection of individual microbial cells without cultivation.

  1995cited by this paper
• Strategies for the discovery of secondary metabolites from marine bacteria: ecological perspectives.

  1994cited by this paper

• Exploring Marine natural products as potential Quorum sensing inhibitors by targeting the PqsR in Pseudomonas aeruginosa: Virtual screening assisted structural dynamics study

  2025cites this paper
• Exploring the Role of Marine Microbial Products in Biodegradable Energy Materials for Green Technologies: A Bibliometric Survey

  2025cites this paper
• Antioxidant and antiproliferative potential of exopolysaccharides from marine diatom Cylindrotheca closterium (Bacillariophyceae)

  2025cites this paper
• Structurally Diverse New Metabolites from Three Hadal Trench-Derived Microorganisms

  2025cites this paper
• Marine-Derived Anti-diabetic Compounds: A Review of Potentials and Prospects

  2025cites this paper
• Metagenomics and its impact on environmental and therapeutic microbiology

  2025cites this paper
• Phenotypic Characterization and Whole-Genome Analysis Revealing the Promising Metabolic Potential of a Newly Isolated Streptomyces sp. CH6

  2025cites this paper
• Exploring Marine Bacterial Secondary Metabolites: Rich Reservoirs of Exceptional and Potent Antimicrobial Agents

  2024cites this paper
• Recent Advances in Marine-Derived Compounds as Potent Antibacterial and Antifungal Agents: A Comprehensive Review

  2024cites this paper
• Comparative Analysis of K-Means Clustering and Watershed Segmentation Techniques for Brain Tumor Detection in MRI

  2024cites this paper
• A new anthraquinone derivative from the marine fish-derived fungus Alternaria sp. X112

  2023cites this paper
• Heterologous expression facilitates the discovery and characterization of marine microbial natural products

  2023cites this paper
• Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain–Many Compounds Strategy and UPLC-QTOF-MS

  2023cites this paper
• Bioprospecting of unexplored halophilic actinobacteria against human infectious pathogens

  2023cites this paper
• In vivo anti-inflammatory activity of M116, one extract obtained from the marine bacterium Bacillus amyloliquefaciens

  2023cites this paper
• Naturally Occurring Organohalogen Compounds-A Comprehensive Review.

  2023cites this paper
• A metagenomic lens into endosphere microbial communities, promises, and discoveries.

  2023cites this paper
• A literature review and future research agenda on fault detection and diagnosis studies in marine machinery systems

  2023cites this paper
• Marine microbial bioprospecting: Exploitation of marine biodiversity towards biotechnological applications—a review

  2022cites this paper
• Advances in mining and expressing microbial biosynthetic gene clusters

  2022cites this paper
• Drug delivery systems for cancer treatment: a review of marine-derived polysaccharides.

  2022cites this paper
• Colonization, diversity, and distribution of endophytic microbial communities in different parts of plants

  2022cites this paper
• Prospecting Microbial Genomes for Biomolecules and Their Applications

  2022cites this paper
• Evaluation of the Marine Bacterial Population in the Great Bitter Lake, Egypt, as a Source of Antimicrobial Secondary Metabolites

  2022cites this paper
• Recent methods for discovering novel bioactive metabolites, specifically antimicrobial agents, from marine‐associated micro‐organisms

  2022cites this paper
• Bioactive Secondary Metabolites from Marine Streptomyces griseorubens f8: Isolation, Identification and Biological Activity Assay

  2021cites this paper
• Marine Organisms as a Rich Source of Biologically Active Peptides

  2021cites this paper
• Isolation and identification of marine microbial products

  2021cites this paper
• Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus Aspergillus sp. HNMF114

  2021cites this paper
• Pharmaceutical biotechnological potential of filamentous fungi isolated from textile industry

  2021cites this paper
• Functional analysis of pristine estuarine marine sediments.

  2021cites this paper
• Accessing previously uncultured marine microbial resources by a combination of alternative cultivation methods

  2021cites this paper
• Transcriptome Analysis reveals possible Antitumor mechanism of Chlorella exopolysaccharide.

  2021cites this paper
• Polyketide-derived macrobrevins from marine macroalga-associated Bacillus amyloliquefaciens as promising antibacterial agents against pathogens causing nosocomial infections.

  2021cites this paper
• Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria

  2020cites this paper
• Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov.

  2020cites this paper
• Carrageenan-Based Acyclovir Mucoadhesive Vaginal Tablets for Prevention of Genital Herpes

  2020cites this paper
• Carrageenan: Drug Delivery Systems and Other Biomedical Applications

  2020cites this paper
• Acylated Aminooligosaccharides from the Yellow Sea Streptomyces sp. HO1518 as Both α-Glucosidase and Lipase Inhibitors

  2020cites this paper
• Application of in situ cultivation in marine microbial resource mining

  2020cites this paper
• Progress in Drug Discovery & Biomedical Science

  2020cites this paper
• Microbial Ecology of Chilika Lagoon

  2020cites this paper
• Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers

  2020cites this paper
• Antibacterial potential of heterotrophic bacteria isolated in Siak River estuary, Indonesia, against pathogens in fish

  2020cites this paper
• Bioactive Metabolites from Streptomyces nanhaiensis VSM-1: Polyphasic Taxonomy, Optimization, and Evaluation of Antimicrobial Metabolites by GC-MS Analysis

  2020cites this paper
• Chemical mining of heterotrophic Shewanella algae reveals anti-infective potential of macrocyclic polyketides against multidrug-resistant pathogens.

  2020cites this paper
• Structural deformation in pathogenic bacteria cells caused by marine fungal metabolites: An in vitro investigation.

  2020cites this paper
• Antioxidant and Antibacterial Natural Products Evaluation from Terrestrial Streptomyces Species Strain KAV 2 Isolated from Rhizosphere Regions of Piper betle

  2019cites this paper
• Biosynthetic Potential of a Novel Antarctic Actinobacterium Marisediminicola antarctica ZS314T Revealed by Genomic Data Mining and Pigment Characterization

  2019cites this paper
• Marine Chitinolytic Pseudoalteromonas Represents an Untapped Reservoir of Bioactive Potential

  2019cites this paper
• Bioactive Compounds Isolated from Marine-Derived Microbes in China: 2009–2018

  2019cites this paper
• Actinobacteria and Cyanobacteria Diversity in Terrestrial Antarctic Microenvironments Evaluated by Culture-Dependent and Independent Methods

  2019cites this paper
• Anti-inflammatory effect of 3,7-dimethyl-1,8-hydroxy-6-methoxyisochroman via nuclear factor erythroid 2-like 2-mediated heme oxygenase-1 expression in lipopolysaccharide-stimulated RAW264.7 and BV2 cells

  2019cites this paper
• Metagenome analysis and interpretation

  2019cites this paper
• Dokdolipids A−C, Hydroxylated Rhamnolipids from the Marine-Derived Actinomycete Actinoalloteichus hymeniacidonis

  2019cites this paper
• Characterization of Drug-like Chemical Space for Cytotoxic Marine Metabolites Using Multivariate Methods

  2019cites this paper
• Lithocarpinols A and B, a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508

  2019cites this paper
• Akazamicin, a cytotoxic aromatic polyketide from marine-derived Nonomuraea sp

  2019cites this paper
• Genome-guided and mass spectrometry investigation of natural products produced by a potential new actinobacterial strain isolated from a mangrove ecosystem in Futian, Shenzhen, China

  2019cites this paper
• Absolute Configuration of Bioactive Azaphilones from the Marine-Derived Fungus Pleosporales sp. CF09-1.

  2019cites this paper
• EFFECT OF STEROL ISOLATE FROM ECHINODERM STELLASTER EQUESTRIS ON ZEBRAFISH (DANIO RERIO)

  2019cites this paper
• Actinomycetes as Continued Source of New Antibacterial Leads

  2019cites this paper
• Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

  2019cites this paper
• Antitumor Potential of Seaweed Derived-Endophytic Fungi

  2019cites this paper
• Bioinformatics for Marine Products: An Overview of Resources, Bottlenecks, and Perspectives

  2019cites this paper
• Total Synthesis of Lajollamycin B.

  2019cites this paper
• Isolation and Characterisation of Halogenated and Bioactive Compounds from Thalassospira sp. and Alteromonas sp.

  2019cites this paper
• The Role of Seaweed Antimicrobials in Selection for Antibiotic Resistance

  2018cites this paper
• Simpterpenoid A, a Meroterpenoid with a Highly Functionalized Cyclohexadiene Moiety Featuring gem-Propane-1,2-dione and Methylformate Groups, from the Mangrove-Derived Penicillium simplicissimum MA-332.

  2018cites this paper
• A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014

  2018cites this paper
• A new macrolactam derivative from the marine actinomycete HF-11225

  2018cites this paper
• Microbial sulfate-reducing activities in anoxic sediment from Marine Lake Grevelingen: screening of electron donors and acceptors

  2018cites this paper
• Rare taxa and dark microbial matter: novel bioactive actinobacteria abound in Atacama Desert soils

  2018cites this paper
• The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis

  2018cites this paper
• Metabolic and Biosynthetic Diversity in Marine Myxobacteria

  2018cites this paper
• Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from Streptomyces sp. HO1518

  2018cites this paper
• Methods for the genetic manipulation of marine bacteria

  2018cites this paper
• Discovery of biomolecules from South Africanmarine sponge symbionts throughMetagenomic studies

  2018cites this paper
• Activity of heterotrophic bacteria from marine area of Siak District against pathogenic bacteria

  2018cites this paper
• Bacteria from Marine Sponges: A Source of Biologically Active Compounds

  2018cites this paper
• Anaerobic Oxidation of Methane Coupled to the Reduction of Different Sulfur Compounds as Electron Acceptors in Bioreactors

  2018cites this paper
• Characterization of antibacterial activity of a novel environmental isolate of Serratia plymuthica

  2018cites this paper
• Characterization of prodiginine compounds produced by a Vibrio species isolated from salt flat sediment along the Florida Gulf Coast

  2017cites this paper
• Delivery of methotrexate using fucoidan/chitosan pH sensitive nanoparticles

  2017cites this paper
• Antitumor Natural Products of Marine-Derived Fungi

  2017cites this paper
• Antibiotic Potency of Extract from Streptomyces Isolated from Terrestrial Soil of Amirthi Forest , India

  2017cites this paper
• Marine microorganisms as a promising and sustainable source of bioactive molecules.

  2017cites this paper
• Daryamide Analogues from a Marine-Derived Streptomyces species.

  2017cites this paper
• Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069

  2017cites this paper
• Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria.

  2017cites this paper
• Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds

  2017cites this paper
• Targeted antimicrobial therapy in the microbiome era

  2017cites this paper
• Structural Elucidation and Identification of 2-Hydroxy Benzoic Acid: An Antibacterial and Cytotoxic Compound from Streptomyces sp. VITHM1 Isolated from Marine Sediment Sample of Alappuzha Beach, Kerala, India

  2017cites this paper
• Production of Antitumor Agents from Novel Marine Actinomycetes Strains Isolated from Alexandria, Egypt

  2017cites this paper
• Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials

  2017cites this paper
• Anaerobic oxidation of methane coupled to the reduction of different sulfur compounds in bioreactors

  2017cites this paper
• Evaluation of fermentation conditions triggering increased antibacterial activity from a near-shore marine intertidal environment-associated Streptomyces species

  2016cites this paper
• Blue-Print Autophagy: Potential for Cancer Treatment

  2016cites this paper
• Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products

  2016cites this paper
• A model to predict anti-tuberculosis activity: value proposition for marine microorganisms

  2016cites this paper