Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Advanced Drug Delivery Reviews

• Publication date

  2009-11-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.addr.2009.06.009PMID 19720100PMCID PMC4120470
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Aging impairs skeletal muscle mitochondrial bioenergetic function.

  2009cited by this paper
• Age‐associated mitochondrial dysfunction in skeletal muscle: Contributing factors and suggestions for long‐term interventions

  2009cited by this paper
• Brain mitochondrial dysfunction in aging

  2008cited by this paper
• Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes.

  2008cited by this paper
• Mitochondrial Transcription Factors TFA, TFB1 and TFB2: A Search for DNA Variants/Haplotypes and the Risk of Cardiac Hypertrophy

  2008cited by this paper
• Hippocampal mitochondrial dysfunction in rat aging.

  2008cited by this paper
• A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

  2008cited by this paper
• Quantification of carnitine and acylcarnitines in biological matrices by HPLC electrospray ionization-mass spectrometry.

  2008cited by this paper
• Role of Acetyl-L-Carnitine in the Treatment of Diabetic Peripheral Neuropathy

  2008cited by this paper
• A DIGE approach for the assessment of rat soleus muscle changes during unloading: effect of acetyl‐L‐carnitine supplementation

  2008cited by this paper
• The Living End – The Future of Death, Aging and ImmortalityThe Living End – The Future of Death, Aging and Immortality

  2008cited by this paper
• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

  2008cited by this paper
• Protective effects of R‐alpha‐lipoic acid and acetyl‐L‐carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid

  2008cited by this paper
• Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

  2008influential reference
• Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.

  2008cited by this paper
• Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha.

  2008cited by this paper
• Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

  2007influential reference
• A new activating role for CO in cardiac mitochondrial biogenesis

  2007cited by this paper
• Fatty acid chain‐elongation in perfused rat heart: Synthesis of stearoylcarnitine from perfused palmitate

  2007cited by this paper
• Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.

  2007cited by this paper
• Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry.

  2007cited by this paper
• Dietary Thioproline Decreases Spontaneous Food Intake and Increases Survival and Neurological Function in Mice

  2007cited by this paper
• Inhibited mitochondrial respiration by amobarbital during cardiac ischaemia improves redox state and reduces matrix Ca2+ overload and ROS release.

  2007cited by this paper
• Protective effect of acetyl‐l‐carnitine on the apoptotic pathway of peripheral neuropathy

  2007cited by this paper
• Coupling of the de Novo Fatty Acid Biosynthesis and Lipoylation Pathways in Mammalian Mitochondria*

  2007cited by this paper
• Acetyl-L-Carnitine in Diabetic Polyneuropathy

  2007cited by this paper
• Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.

  2006influential reference
• Blockade of Electron Transport before Cardiac Ischemia with the Reversible Inhibitor Amobarbital Protects Rat Heart Mitochondria

  2006cited by this paper
• Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2*

  2006cited by this paper
• Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

  2006cited by this paper
• SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

  2006cited by this paper
• Oxidative phosphorylation and aging.

  2006influential reference
• Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

  2006influential reference
• Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis.

  2006cited by this paper
• Photolabeling of cardiolipin binding subunits within bovine heart cytochrome c oxidase.

  2006cited by this paper
• Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.

  2006cited by this paper
• Reversible Blockade of Electron Transport during Ischemia Protects Mitochondria and Decreases Myocardial Injury following Reperfusion

  2006cited by this paper
• Interaction of peroxidized cardiolipin with rat‐heart mitochondrial membranes: Induction of permeability transition and cytochrome c release

  2006cited by this paper
• Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease

  2005cited by this paper
• Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine.

  2005cited by this paper
• Age-related changes in ATP-producing pathways in human skeletal muscle in vivo.

  2005cited by this paper
• Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2

  2005influential reference
• Isolation and identification of two isomeric forms of malonyl-coenzyme A in commercial malonyl-coenzyme A.

  2004cited by this paper
• Aging as a catabolic malfunction.

  2004cited by this paper
• Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer.

  2004influential reference
• Role of Mitochondrial Dysfunction in Neurotoxicity of MPP:+: Partial Protection of PC12 Cells by Acetyl‐l‐Carnitine

  2004cited by this paper
• Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging.

  2004influential reference
• Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type

  2004cited by this paper
• Blockade of Electron Transport during Ischemia Protects Cardiac Mitochondria*

  2004cited by this paper
• Acetyl‐l‐Carnitine Dietary Supplementation to Old Rats Increases Mitochondrial Transcription Factor A Content in Rat Hindlimb Skeletal Muscles

  2004cited by this paper
• Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain – potential role of L-Carnitine

  2004cited by this paper
• Carnitine acyltransferases and their influence on CoA pools in health and disease.

  2004cited by this paper
• Histone deacetylase in carcinogenesis and its inhibitors as anti-cancer agents.

  2003cited by this paper
• Cardiolipin Stabilizes Respiratory Chain Supercomplexes*

  2003cited by this paper
• Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease

  2003cited by this paper
• Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans

  2003cited by this paper
• Production of Reactive Oxygen Species by Mitochondria

  2003cited by this paper
• Human skeletal muscle mitochondrial metabolism in youth and senescence: no signs of functional changes in ATP formation and mitochondrial oxidative capacity

  2003cited by this paper
• Aging defect at the QO site of complex III augments oxyradical production in rat heart interfibrillar mitochondria.

  2003cited by this paper
• Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria.

  2003cited by this paper
• Acetylation and level of mitochondrial transcription factor A in several organs of young and old rats.

  2003cited by this paper
• Hepatic mitochondrial dysfunction in senescence‐accelerated mice: correction by long‐term, orally administered physiological levels of melatonin

  2002cited by this paper
• Neural Substrates of Human Facial Expression of Pleasant Emotion Induced by Comic Films: A PET Study

  2002cited by this paper
• Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid

  2002cited by this paper
• Phospholipid-Cytochrome c Interaction EVIDENCE FOR THE EXTENDED LIPID ANCHORAGE*

  2002cited by this paper
• Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

  2002cited by this paper
• Skeletal muscle oxidative capacity in rats fed high-fat diet

  2002cited by this paper
• Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats.

  2002cited by this paper
• Delaying Brain Mitochondrial Decay and Aging with Mitochondrial Antioxidants and Metabolites

  2002influential reference
• Phospholipid-Cytochrome c Interaction

  2002cited by this paper
• Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l- carnitine and/or R-α-lipoic acid

  2002cited by this paper
• Mitochondrial Abnormalities in Alzheimer's Disease

  2001cited by this paper
• Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content.

  2001cited by this paper
• ENERGY TRANSDUCTION BY COUPLING OF PROTON TRANSLOCATION TO ELECTRON TRANSFER BY THE CYTOCHROME bc, COMPLEX*

  2001cited by this paper
• Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria.

  2001cited by this paper
• Do mammalian cells synthesize lipoic acid?

  2001cited by this paper
• Ischemic injury to mitochondrial electron transport in the aging heart: damage to the iron-sulfur protein subunit of electron transport complex III.

  2001influential reference
• Mitochondria, aging and longevity – a new perspective

  2001cited by this paper
• Mitochondrial dysfunction in cardiac disease: ischemia--reperfusion, aging, and heart failure.

  2001cited by this paper
• Aging decreases electron transport complex III activity in heart interfibrillar mitochondria by alteration of the cytochrome c binding site.

  2001cited by this paper
• [Mitochondria and apoptosis].

  2000cited by this paper
• Mitochondrial free radical generation, oxidative stress, and aging.

  2000cited by this paper
• Heme oxygenase-1: role in brain aging and neurodegeneration.

  2000cited by this paper
• Redundant roles for the TFIID and SAGA complexes in global transcription

  2000cited by this paper
• The biosynthesis and functional role of cardiolipin.

  2000cited by this paper
• Age-related changes in activities of mitochondrial electron transport complexes in various tissues of the mouse.

  2000cited by this paper
• Overexpression of Heme Oxygenase in Neuronal Cells, the Possible Interaction with Tau*

  2000cited by this paper
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  1999cited by this paper
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• Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.

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• Mechanism of ubiquinol oxidation by the bc(1) complex: role of the iron sulfur protein and its mobility.

  1999cited by this paper
• Mechanism of ubiquinol oxidation by the bc(1) complex: different domains of the quinol binding pocket and their role in the mechanism and binding of inhibitors.

  1999cited by this paper
• Mitochondrial respiratory chain activity in the human brain as a function of age.

  1999cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Role of Acetyl‐l‐Carnitine in Rat Brain Lipogenesis: Implications for Polyunsaturated Fatty Acid Biosynthesis

  1998cited by this paper
• Influences of Caloric Restriction on Age‐associated Skeletal Muscle Fiber Characteristics and Mitochondrial Changes in Rats and Mice a

  1998cited by this paper
• Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity.

  1998cited by this paper
• Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*

  1998cited by this paper
• Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction.

  1998cited by this paper

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