Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Molecular Aspects of Medicine

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.mam.2011.10.007PMID 22020114
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2011influential reference
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  2009influential reference
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