Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Genesis

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/gene.20039PMID 15282742
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors.

  2003cited by this paper
• Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes.

  2003cited by this paper
• Molecular aspects of bile formation and cholestasis.

  2003cited by this paper
• A tamoxifen‐inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver

  2002influential reference
• New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.

  2002cited by this paper
• A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene.

  2002cited by this paper
• Liver protein synthesis in physiology and in disease states.

  2002cited by this paper
• Temporally controlled targeted somatic mutagenesis in the mouse brain

  2001influential reference
• Efficient FLP recombination in mouse ES cells and oocytes

  2001cited by this paper
• Site- and time-specific gene targeting in the mouse.

  2001cited by this paper
• Molecular mechanisms of translation initiation in eukaryotes

  2001cited by this paper
• Targeted Somatic Mutagenesis in Mouse Epidermis

  2001influential reference
• DNA excision in liver by an albumin‐Cre transgene occurs progressively with age

  2000cited by this paper
• Hepatocyte‐specific expression of Cre recombinase

  2000cited by this paper
• Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.

  2000cited by this paper
• Inducible site‐specific somatic mutagenesis in mouse hepatocytes

  2000cited by this paper
• Inducible site-specific recombination in the brain.

  1999cited by this paper
• Normal growth and development in the absence of hepatic insulin-like growth factor I.

  1999cited by this paper
• Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases.

  1999influential reference
• The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.

  1998cited by this paper
• A new logic for DNA engineering using recombination in Escherichia coli

  1998cited by this paper
• Temporally and spatially regulated somatic mutagenesis in mice.

  1998cited by this paper
• Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

  1997cited by this paper
• Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains.

  1997cited by this paper
• Ligand-activated site-specific recombination in mice.

  1996cited by this paper
• Construction of a bifunctional mRNA in the mouse by using the internal ribosomal entry site of the encephalomyocarditis virus

  1992cited by this paper
• Gene targeting in embryonic stem cells.

  1991cited by this paper
• Albumin and alpha-fetoprotein gene expression in various nonhepatic rat tissues.

  1988cited by this paper
• Hepatology: A Textbook of Liver Disease

  1983cited by this paper
• The Anatomy and Physiology of the Liver

  1834cited by this paper

• Glucocorticoid-dependence and independence of the circadian liver transcriptome

  2026cites this paper
• Redox-dependent liver gluconeogenesis impacts different intensity exercise in mice

  2025cites this paper
• HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

  2025cites this paper
• A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS

  2025cites this paper
• Development of a Hepatocyte‐Specific Temporal Genetic Mouse Model Using Albumin Promoter‐Driven FlpER2 Expression

  2025cites this paper
• DNA replication in primary hepatocytes without the six-subunit ORC

  2025cites this paper
• SMG6-dependent nonsense-mediated decay maintains dsRNA homeostasis and suppresses immunogenic transcripts in a hepatocellular carcinoma model

  2025cites this paper
• Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice

  2025cites this paper
• Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates

  2025cites this paper
• Macrophages harness hepatocyte glutamate to boost liver regeneration

  2025cites this paper
• Reducing the CAV1-dependent trafficking of G6PC1 in the liver protects against the development of type 2 diabetes

  2025cites this paper
• Necroptosis induced by MLKL overexpression in liver triggers cellular senescence and leads to chronic inflammation and fibrosis.

  2025cites this paper
• Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage

  2024cites this paper
• Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing.

  2024cites this paper
• Hepatocyte nuclear factor 4α is a critical factor for the production of complement components in the liver

  2024cites this paper
• A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

  2024cites this paper
• Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease

  2024cites this paper
• Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery

  2024cites this paper
• Dietary protein load affects the energy and nitrogen balance requiring liver glutamate dehydrogenase to maintain physical activity

  2024cites this paper
• Liver-specific glucocorticoid action in alcoholic liver disease: Study of glucocorticoid receptor knockout and knockin mice

  2024cites this paper
• Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

  2024cites this paper
• Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring

  2024cites this paper
• Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations

  2024cites this paper
• The circadian demethylation of a unique intronic deoxymethylCpG-rich island boosts the transcription of its cognate circadian clock output gene

  2023cites this paper
• A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway

  2023cites this paper
• The HP1α protein is mandatory to repress the circadian clock and its output genes during the 12 h period of transcriptional repression

  2023cites this paper
• Gene therapy and genome editing for type I glycogen storage diseases

  2023cites this paper
• Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages.

  2023cites this paper
• Fetal liver development and implications for liver disease pathogenesis

  2023cites this paper
• A highly sensitive strategy for monitoring real-time proliferation of targeted cell types in vivo

  2023cites this paper
• NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes

  2023cites this paper
• Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.

  2023cites this paper
• Liver-specific glucocorticoid action in alcoholic liver disease: study of glucocorticoid receptor knockout and knockin mice

  2023cites this paper
• TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

  2022cites this paper
• RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

  2022cites this paper
• Distinct phenotypic spectra of hepatocellular carcinoma in liver-specific tumor suppressor-deficient hepatitis B virus transgenic mice.

  2022cites this paper
• Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

  2022cites this paper
• A non-canonical vitamin K cycle is a potent ferroptosis suppressor

  2022cites this paper
• Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade

  2022cites this paper
• Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis

  2022cites this paper
• Fasting-induced renal HMGCS2 expression does not contribute to circulating ketones.

  2022cites this paper
• A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway

  2022cites this paper
• The cell cycle inhibitor RB is diluted in G1 and contributes to controlling cell size in the mouse liver

  2022cites this paper
• Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

  2022cites this paper
• HNF4A modulates glucocorticoid action in the liver

  2022cites this paper
• A novel Smg6 mouse model reveals circadian clock regulation through the 1 nonsense-mediated mRNA decay pathway 2

  2022influential citation
• Induction of whole-body gene deletion via R26-regulated tamoxifen-inducible Cre recombinase activity

  2022cites this paper
• Depletion of Tip60/Kat5 affects the hepatic antioxidant system in mice

  2022cites this paper
• Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome

  2022cites this paper
• Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation

  2022cites this paper
• Molecular mechanism underlying impaired hepatic autophagy in glycogen storage disease type Ib.

  2022cites this paper
• Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling

  2021cites this paper
• β-Catenin Signaling Regulates the In Vivo Distribution of Hepatitis B Virus Biosynthesis across the Liver Lobule

  2021cites this paper
• HNF4A is required to specify glucocorticoid action in the liver

  2021cites this paper
• Redundant Functions of ERK1 and ERK2 Maintain Mouse Liver Homeostasis Through Down‐Regulation of Bile Acid Synthesis

  2021cites this paper
• Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice

  2021cites this paper
• KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

  2020cites this paper
• Decreased Hepatocyte Autophagy Leads to Synergistic IL‐1β and TNF Mouse Liver Injury and Inflammation

  2020cites this paper
• Identifying strategies to target the metabolic flexibility of tumours

  2020cites this paper
• Induction of steatohepatitis and liver tumorigenesis by enforced Snail expression in hepatocytes.

  2020cites this paper
• Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle

  2020cites this paper
• The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation

  2020cites this paper
• Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism

  2020cites this paper
• Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids

  2020cites this paper
• Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism

  2020cites this paper
• Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism

  2020cites this paper
• Cell-autonomous hepatocyte-specific GP130 signalling is sufficient to trigger a robust innate immune response in mice.

  2020cites this paper
• Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

  2020influential citation
• In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way

  2019cites this paper
• Investigating the Functional Consequence of Pik3c2b Ablation in a Skeletal Muscle Model

  2019cites this paper
• Skeletal muscle mTORC1 regulates neuromuscular junction stability

  2019cites this paper
• Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/Taz

  2019influential citation
• HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.

  2019cites this paper
• Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function

  2019cites this paper
• Diverse Consequences in Liver Injury in Mice with Different Autophagy Functional Status Treated with Alcohol.

  2019cites this paper
• Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

  2018cites this paper
• Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes

  2018cites this paper
• Reaction and Tumorigenesis in Autophagy-deficient Livers

  2018cites this paper
• Mouse models of peripheral metabolic disease.

  2018cites this paper
• Endoreduplication of the mouse genome in the absence of ORC1

  2018influential citation
• Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis

  2018cites this paper
• HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

  2018cites this paper
• Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair

  2018influential citation
• γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.

  2018influential citation
• Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

  2018cites this paper
• Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.

  2018cites this paper
• Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

  2018cites this paper
• Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

  2018cites this paper
• The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ

  2018cites this paper
• Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

  2018cites this paper
• Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid–Derived Gluconeogenesis and Ammonia Homeostasis

  2018cites this paper
• Metabolic adaptations in models of fatty liver disease Hijmans

  2017cites this paper
• Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia

  2017cites this paper
• Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling

  2017cites this paper
• Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model

  2017cites this paper
• Metabolic adaptations in models of fatty liver disease: Of mice and math

  2017cites this paper
• Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

  2017cites this paper
• Shifting eating creates a misalignment of peripheral and central circadian clocks, which leads to a metabolic syndrome

  2016cites this paper
• Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease

  2016cites this paper
• Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption

  2016cites this paper