Enhanced Functional Gap Junction Neoformation by Protein Kinase A–Dependent and Epac-Dependent Signals Downstream of cAMP in Cardiac Myocytes

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Circulation Research

• Publication date

  2005-09-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.RES.0000183880.49270.f9PMID 16123333
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase.

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• Effects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart.

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• Rap1 Regulates the Formation of E-Cadherin-Based Cell-Cell Contacts

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• Gap junctions and the connexin protein family.

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• Connexin 43 and ischemic preconditioning.

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• EphA4-Mediated Rho Activation via Vsm-RhoGEF Expressed Specifically in Vascular Smooth Muscle Cells

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• Crosstalk between Rap1 and Rac regulates secretion of sAPPα

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• α1 connexin (connexin43) gap junctions and activities of cAMP‐dependent protein kinase and protein kinase C in developing mouse heart

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• A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

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• Dominant-negative connexin43-EGFP inhibits calcium-transient synchronization of primary neonatal rat cardiomyocytes.

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• Conditional Gene Targeting of Connexin43: Exploring the Consequences of Gap Junction Remodeling in the Heart

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• v-Src phosphorylation of connexin 43 on Tyr247 and Tyr265 disrupts gap junctional communication

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• Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP

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• Requirement for C3G‐dependent Rap1 activation for cell adhesion and embryogenesis

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• Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication

  2000cited by this paper
• Wnt-1 regulation of connexin43 in cardiac myocytes.

  2000cited by this paper
• Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking.

  2000cited by this paper
• Connexin expression and turnover : implications for cardiac excitability.

  2000cited by this paper
• Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture.

  1999cited by this paper
• Chamber-related differences in connexin expression in the human heart.

  1999cited by this paper
• Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)

  1999cited by this paper
• Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

  1998cited by this paper
• Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes*

  1998cited by this paper
• A family of cAMP-binding proteins that directly activate Rap1.

  1998cited by this paper
• Structure of cardiac gap junction intercellular channels.

  1998cited by this paper
• Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

  1997cited by this paper
• Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.

  1996cited by this paper
• Impaired regulation of cell communication by beta-adrenergic receptor activation in the failing heart.

  1996cited by this paper
• N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes.

  1996cited by this paper
• Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes.

  1996cited by this paper
• Impaired Regulation of Cell Communication by β-Adrenergic Receptor Activation in the Failing Heart

  1996cited by this paper
• Gap Junction Protein Phenotypes of the Human Heart and Conduction System

  1995cited by this paper
• A 135‐kd membrane protein of intercellular adherens junctions.

  1984cited by this paper

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  2020cites this paper
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  2018cites this paper
• Exendin‐4 overcomes cytokine‐induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets

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  2018cites this paper
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  2017cites this paper
• Biological Sex Differences in the Gene Expression and Contractile Function of Cardiac Myocytes

  2017cites this paper
• Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion

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