Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Philosophical Transactions of the Royal Society B: Biological Sciences

• Publication date

  2010-05-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1098/rstb.2009.0114PMID 20403873PMCID PMC2871914
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Conclusions and Future Perspectives

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• Connexin 43 a potential regulator of cell proliferation and apoptosis within the seminiferous epithelium.

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• The effects of cryptorchidism on the regulation of steroidogenesis and gap junctional communication in equine testes.

  2008cited by this paper
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• Aberrant Cytoplasmic Accumulation of Connexin 43 in Human Testicular Seminoma~!2008-07-21~!2008-10-15~!2008-12-05~!

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• Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43.

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• Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: an early event of DDT carcinogenicity.

  2008cited by this paper
• 17Beta-Estradiol Induces the Translocation of the Estrogen Receptors ESR1 and ESR2 to the Cell Membrane, MAPK3/1 Phosphorylation and Proliferation of Cultured Immature Rat Sertoli Cells1

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  2008cited by this paper
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  2008cited by this paper
• Influence of municipal effluents on the expression of connexins in the brook trout (Salvelinus fontinalis) testis.

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• Advances in male contraception.

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  2007cited by this paper
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  2007cited by this paper
• The role of connexins in controlling cell growth and gene expression.

  2007cited by this paper
• The Expression of Multiple Connexins Throughout Spermatogenesis in the Rainbow Trout Testis Suggests a Role for Complex Intercellular Communication1

  2007cited by this paper
• Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation

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• Role of testicular interleukin-1alpha tIL-1alpha in testicular physiology and disease.

  2006cited by this paper
• Opposite regulation of connexin33 and connexin43 by LPS and IL-1alpha in spermatogenesis.

  2006cited by this paper
• Transition from preinvasive carcinoma in situ to seminoma is accompanied by a reduction of connexin 43 expression in Sertoli cells and germ cells.

  2006cited by this paper
• Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium

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• Connexin 43 expression in the testis of the frog Rana esculenta

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• The vertebrate connexin family

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• A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones

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• Role of connexin-based gap junction channels in testis.

  2005cited by this paper
• c-Src: Bridging the Gap Between Phosphorylation- and Acidification-Induced Gap Junction Channel Closure

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• Enhanced Functional Gap Junction Neoformation by Protein Kinase A–Dependent and Epac-Dependent Signals Downstream of cAMP in Cardiac Myocytes

  2005cited by this paper
• Cell junctions in the germinal epithelium may play an important role in spermatogenesis of the catfish P. fasciatum (Pisces, Siluriformes)

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• Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease.

  2005cited by this paper
• Gap junctions and the propagation of cell survival and cell death signals

  2005cited by this paper
• Nonylphenol Alters Connexin 43 Levels and Connexin 43 Phosphorylation Via an Inhibition of the p38-Mitogen-Activated Protein Kinase Pathway1

  2005cited by this paper
• Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?

  2005cited by this paper
• Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis.

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• Functional characterization of Cx43 based gap junctions during spermatogenesis

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• Consumption of xenoestrogen-contaminated fish during lactation alters adult male reproductive function.

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• Dominant negative effect of connexin33 on gap junctional communication is mediated by connexin43 sequestration

  2004cited by this paper
• From carcinoma in situ to testicular germ cell tumour

  2004cited by this paper
• Disrupted traffic of connexin 43 in human testicular seminoma cells: overexpression of Cx43 induces membrane location and cell proliferation decrease

  2004cited by this paper
• Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants.

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• Incorporation of connexins into plasma membranes and gap junctions.

  2004cited by this paper
• The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins.

  2004cited by this paper
• Adaptors, Junction Dynamics, and Spermatogenesis1

  2004cited by this paper
• Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display.

  2003cited by this paper
• Plasma membrane channels formed by connexins: their regulation and functions.

  2003cited by this paper
• Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray.

  2003cited by this paper
• Gene Expression Profiles in Different Stages of Mouse Spermatogenic Cells During Spermatogenesis1

  2003cited by this paper
• Impaired Gap Junction Connexin43 in Sertoli Cells of Patients with Secretory Azoospermia: A Marker of Undifferentiated Sertoli Cells

  2003cited by this paper
• Disruption of gap junctions in toxicity and carcinogenicity.

  2003cited by this paper
• Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway.

  2003cited by this paper
• Modulation of gap junction mediated intercellular communication in TM3 Leydig cells.

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• An Update on Connexin Genes and their Nomenclature in Mouse and Man

  2003cited by this paper
• Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood.

  2003cited by this paper
• Pannexins, a family of gap junction proteins expressed in brain

  2003cited by this paper
• mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse.

  2003cited by this paper
• Sequestration of connexin43 in the early endosomes: An early event of Leydig cell tumor progression

  2003cited by this paper
• Differences in expression patterns between mouse connexin‐30.2 (Cx30.2) and its putative human orthologue, connexin‐31.9 1

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• Connexin 47 (Cx47)-Deficient Mice with Enhanced Green Fluorescent Protein Reporter Gene Reveal Predominant Oligodendrocytic Expression of Cx47 and Display Vacuolized Myelin in the CNS

  2003cited by this paper
• Neonatal Hypothyroidism Alters the Localization of Gap Junctional Protein Connexin 43 in the Testis and Messenger RNA Levels in the Epididymis of the Rat1

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  2002cited by this paper
• Molecular Cloning, Functional Expression, and Tissue Distribution of a Novel Human Gap Junction-forming Protein, Connexin-31.9

  2002cited by this paper
• A germline-specific gap junction protein required for survival of differentiating early germ cells.

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  2002cited by this paper
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• Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome

  2002cited by this paper
• Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40.

  2002cited by this paper
• DI-(2-ETHYLHEXYL) PHTHALATE-INDUCED CELL PROLIFERATION IS INVOLVED IN THE INHIBITION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION AND BLOCKAGE OF APOPTOSIS IN MOUSE SERTOLI CELLS

  2002cited by this paper
• Gap junctions as targets for cancer chemoprevention and chemotherapy.

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• Developmental regulation of connexin 43 expression in fetal mouse testicular cells

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• Failure of Spermatogenesis in Mice Lacking Connexin431

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• Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells.

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• Expression of Connexin43 in mouse Leydig, Sertoli, and germinal cells at different stages of postnatal development

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• Impaired Conduction in the Bundle Branches of Mouse Hearts Lacking the Gap Junction Protein Connexin40

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• Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation.

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• Unique and shared functions of different connexins in mice.

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• Connexin43 Gene Expression and Regulation in the Rodent Seminiferous Epithelium

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