TUSC4 functions as a tumor suppressor by regulating BRCA1 stability.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cancer Research

• Publication date

  2015-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-14-2315PMID 25480944PMCID PMC4804342
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
• The hallmarks of cancer

  2012cited by this paper
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  2012cited by this paper
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  2012cited by this paper
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  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• BRIT1/MCPH1 Links Chromatin Remodeling to DNA Damage Response

  2009cited by this paper
• Tumor suppressors and cell metabolism: a recipe for cancer growth.

  2009influential reference
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  2009cited by this paper
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  2008cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
• Mechanism of homologous recombination: mediators and helicases take on regulatory functions

  2006cited by this paper
• Basal-like breast cancer and the BRCA1 phenotype

  2006cited by this paper
• [Non-homologous DNA end joining].

  2005cited by this paper
• The role of BRCA1 in the cellular response to chemotherapy.

  2004cited by this paper
• Re: Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Chk1 and Chk2 kinases in checkpoint control and cancer.

  2003cited by this paper
• Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

  2002cited by this paper
• Caretaker tumour suppressor genes that defend genome integrity.

  2002cited by this paper
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Role played by BRCA1 in regulating the cellular response to stress.

  2001cited by this paper
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  2001cited by this paper
• Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

  2000cited by this paper
• DNA double strand break repair in mammalian cells.

  2000cited by this paper
• The DNA damage response: putting checkpoints in perspective

  2000cited by this paper
• A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper

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  2016cites this paper
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  2016cites this paper
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