Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction

Zhuzhi Wen,Shao‐xin Zheng,Changqing Zhou,Jingfeng Wang,Tong Wang

Published 2011 in Journal of Cellular and Molecular Medicine

ABSTRACT

•  Introduction •  Transdifferentiation ‐  MSCs differentiate into cardiomyocytes ‐  MSCs differentiate into vascular cells •  Paracrine effects ‐  Endogenous cardiac regeneration induced by paracrine effects ‐  Neovascularization induced by paracrine effects ‐  Anti‐inflammatory effect of MSCs ‐  Anti‐apoptotic effects by MSCs ‐  Cardiac remodelling induced by paracrine effects ‐  Paracrine‐mediated cardiac contractility ‐  Cardiac metabolic modulation by MSCs •  Other potential effects ‐  Cardiac nerve sprouting ‐  Anti‐arrhythmic potential •  Conclusion

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