Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Neuron

• Publication date

  2001-08-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0896-6273(01)00356-7PMID 11502255
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Inhibition of P-glycoprotein ATPase activity by beryllium fluoride.

  1997influential reference
• Regulation of KATP Channel Activity by Diazoxide and MgADP

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• Inhibition of myosin ATPase by vanadate ion.

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