Influenza A virus-generated small RNAs regulate the switch from transcription to replication

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1001984107PMID 20534471PMCID PMC2895093
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998cited by this paper
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  1996cited by this paper
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  1981cited by this paper
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  1980cited by this paper
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  1979cited by this paper
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  1977cited by this paper
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  1971cited by this paper

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