Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cancer Research

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 14612554
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.

  2003cited by this paper
• Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria.

  2002cited by this paper
• High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.

  2002cited by this paper
• Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.

  2002cited by this paper
• Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.

  2002cited by this paper
• Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.

  2002cited by this paper
• Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes.

  2001cited by this paper
• Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.

  2001cited by this paper
• Potent induction of phase 2 enzymes in human prostate cells by sulforaphane.

  2001cited by this paper
• Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase‐3 activation

  2001cited by this paper
• Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane

  2001cited by this paper
• Signal transduction events elicited by cancer prevention compounds.

  2001cited by this paper
• Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro.

  2001cited by this paper
• Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates.

  2001cited by this paper
• Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.

  2001cited by this paper
• Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes.

  2001influential reference
• Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.

  2000cited by this paper
• p38 Mitogen-activated Protein Kinase Negatively Regulates the Induction of Phase II Drug-metabolizing Enzymes That Detoxify Carcinogens*

  2000cited by this paper
• Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.

  2000cited by this paper
• Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli

  2000cited by this paper
• Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells.

  2000cited by this paper
• Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

  2000influential reference
• Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death

  2000influential reference
• Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals*

  1999influential reference
• Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity.

  1998cited by this paper
• Death receptors: signaling and modulation.

  1998cited by this paper
• Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates*

  1998cited by this paper
• Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes.

  1997cited by this paper
• An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

  1997cited by this paper
• Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates.

  1997cited by this paper
• Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene.

  1996cited by this paper
• Parallel signal processing among mammalian MAPKs.

  1995cited by this paper
• Chemoprevention by isothiocyanates

  1995cited by this paper
• Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

  1995cited by this paper
• Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

  1994influential reference
• Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

  1990cited by this paper
• Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine.

  1980cited by this paper

• The Multifaceted Health Benefits of Broccoli—A Review of Glucosinolates, Phenolics and Antimicrobial Peptides

  2025cites this paper
• Hydroethanolic Extract of Polygonum aviculare L. Mediates the Anti-Inflammatory Activity in RAW 264.7 Murine Macrophages Through Induction of Heme Oxygenase-1 and Inhibition of Inducible Nitric Oxide Synthase

  2024cites this paper
• Anti-Inflammatory Therapeutic Mechanisms of Isothiocyanates: Insights from Sulforaphane

  2024cites this paper
• Exploring the anti‐inflammatory activity of sulforaphane

  2023cites this paper
• Quantification and Diversity Analyses of Major Glucosinolates in Conserved Chinese Cabbage (Brassica rapa L. ssp. pekinensis) Germplasms

  2023cites this paper
• Phenylpropionic acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

  2023cites this paper
• Glucosinolates and Omega-3 Fatty Acids from Mustard Seeds: Phytochemistry and Pharmacology

  2022cites this paper
• GSH Levels Serve As a Biological Redox Switch Regulating Sulforaphane-Induced Cell Fate in Human Lens Cells

  2021cites this paper
• DNA methylome, transcriptome, and prostate cancer prevention by phenethyl isothiocyanate in TRAMP mice

  2021cites this paper
• Evaluating the Anti-Inflammatory and Antioxidant Effects of Broccoli Treated with High Hydrostatic Pressure in Cell Models

  2021cites this paper
• Sulforaphane as an anticancer molecule: mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems

  2020cites this paper
• Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein.

  2019cites this paper
• Protects the Liver against CdSe Quantum Dot-Induced Cytotoxicity. Research

  2019cites this paper
• Antioxidant effects of sulforaphane in human HepG2 cells and immortalised hepatocytes.

  2019cites this paper
• Improved extraction of resveratrol and antioxidants from grape peel using heat and enzymatic treatments.

  2019cites this paper
• Anti-inflammatory and antioxidant effects of 2, 7-dihydroxy-4, 6-dimethoxy phenanthrene isolated from Dioscorea batatas Decne

  2019cites this paper
• Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models.

  2019cites this paper
• Characterization of Transcriptional Activities

  2019cites this paper
• Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

  2018cites this paper
• Structures of isothiocyanates attributed to reactive oxygen species generation and microtubule depolymerization in HepG2 cells.

  2018cites this paper
• Soy-derived phytoalexins: mechanism of in vivo biological effectiveness in spite of their low bioavailability

  2018cites this paper
• Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis

  2018cites this paper
• Protective Effect of Dioscorea batatas Peel Extract Against Intestinal Inflammation

  2018cites this paper
• Chemopreventive Activities of Sulforaphane and Its Metabolites in Human Hepatoma HepG2 Cells

  2018cites this paper
• Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts

  2018cites this paper
• Anticancer activity of sulforaphane and allyl isothiocyanate- conjugated silicon quantum dots

  2017cites this paper
• In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
• Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway.

  2017cites this paper
• Antioxidant Potential of Selected Korean Edible Plant Extracts

  2017cites this paper
• Correction to: In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
• Exploring Concentration and Duration Dependence in Hormesis

  2017cites this paper
• In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
• Title: Effects of Broccoli-Derived Sulphur Compounds on the Prostate Microenvironment

  2017influential citation
• Suppression of Nrf2 Activity by Chestnut Leaf Extract Increases Chemosensitivity of Breast Cancer Stem Cells to Paclitaxel

  2017cites this paper
• An investigation of curcumin derivatives and their effects in prostate cancer

  2017cites this paper
• Screening active components of modified Xiaoyao powder as NRF2 agonists

  2017cites this paper
• The roles of microRNAs in the anti-cancer effects of sulforaphane from cruciferous vegetables

  2017cites this paper
• Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.

  2016cites this paper
• Bioavailability of Glucosinolates and Their Breakdown Products: Impact of Processing

  2016cites this paper
• Epigenetics reactivation of Nrf2 in Prostate TRAMP C1 Cells by curcumin analog FN1

  2016cites this paper
• Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes

  2016influential citation
• Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in HepG2 cells.

  2016influential citation
• Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms.

  2016cites this paper
• Sulforaphane Protects the Liver against CdSe Quantum Dot-Induced Cytotoxicity

  2015cites this paper
• Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

  2015cites this paper
• RESEARCH Anti-proliferation Effects of Isorhamnetin on Lung Cancer Cells in Vitro and in Vivo

  2015cites this paper
• Metabolism and antiproliferative effects of sulforaphane and broccoli sprouts in human intestinal (Caco-2) and hepatic (HepG2) cells

  2015cites this paper
• Anti-proliferation effects of isorhamnetin on lung cancer cells in vitro and in vivo.

  2015cites this paper
• Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals

  2014cites this paper
• The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway.

  2014cites this paper
• Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway.

  2013cites this paper
• Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation.

  2013cites this paper
• Investigating the putative therapeutic effects of sulfophane in the human lens

  2013cites this paper
• Oxidative stress induction by sulforaphane on human osteosarcoma

  2013influential citation
• The molecular mechanism of action of aspirin, curcumin and sulforaphane combinations in the chemoprevention of pancreatic cancer

  2013cites this paper
• Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations.

  2012cites this paper
• Role of Nutraceuticals on Nrf2 and Its Implication in Cancer Prevention

  2012cites this paper
• 4-iodophenyl isothiocyanate: A neuroprotective compound

  2012cites this paper
• The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors

  2012cites this paper
• Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.

  2012cites this paper
• Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.

  2012cites this paper
• Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against oxidative stress-induced cell death.

  2012cites this paper
• Evaluation of Cytotoxic Properties of Caffeine Treated with Over-the-counter Drugs in the Intestinal Cells

  2012influential citation
• Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival

  2011cites this paper
• Nrf2‐mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae

  2011cites this paper
• 1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level.

  2011cites this paper
• Antioxidant Capacity and Quinone Reductase Activity of Methanol Extracts and Fractions from Papaya Seed

  2011cites this paper
• A mechanistic insight into MDMA-mediated hepatotoxicity

  2011cites this paper
• Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.

  2011cites this paper
• Cruciferous Vegetables - and Biological Activity of Isothiocyanates and Indoles

  2011cites this paper
• Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2‐mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates

  2011cites this paper
• Kaempferol Suppresses Cisplatin-Induced Apoptosis Via Inductions of Heme Oxygenase-1 and Glutamate-Cysteine Ligase Catalytic Subunit in HEI-OC1 cells

  2010cites this paper
• PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione.

  2010cites this paper
• Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells

  2010cites this paper
• Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity

  2010cites this paper
• Redox-dependent signaling system Nrf2/ARE in inflammation

  2010cites this paper
• Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes.

  2010cites this paper
• Cruciferous Vegetables, Isothiocyanates, Indoles, and Cancer Prevention

  2010cites this paper
• After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult.

  2010cites this paper
• Icaritin induces apoptosis of HepG2 cells via the JNK1 signaling pathway independent of the estrogen receptor.

  2010cites this paper
• Icaritin Induces Apoptosis of HepG2 Cells via the JNK1 Signaling Pathway Independent of the Estrogen Receptor

  2010cites this paper
• Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response.

  2010cites this paper
• Bio-protective effects of glucosinolates - a review.

  2009cites this paper
• Apoptosis induction by sulfur‐containing compounds in malignant and nonmalignant human cells

  2009cites this paper
• Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.

  2009cites this paper
• Effect of sulforaphane on glutathione-adduct formation and on glutathione_S_transferase-dependent detoxification of acrylamide in Caco-2 cells.

  2009cites this paper
• Isoalantolactone from Inula helenium Caused Nrf2-Mediated Induction of Detoxifying Enzymes

  2009cites this paper
• Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytes.

  2009cites this paper
• Combination Treatment with Resveratrol and Sulforaphane Induces Apoptosis in Human U251 Glioma Cells

  2009cites this paper
• The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

  2009cites this paper
• Alleviation of dimethylnitrosamine-induced liver injury and fibrosis by betaine supplementation in rats.

  2009cites this paper
• MTBITC mediates cell cycle arrest and apoptosis induction in human HepG2 cells despite its rapid degradation kinetics in the in vitro model

  2009cites this paper
• Synergistic Effects of a Combination of Dietary Factors Sulforaphane and (−) Epigallocatechin-3-gallate in HT-29 AP-1 Human Colon Carcinoma Cells

  2008cites this paper
• Structural Influence of Isothiocyanates on the Antioxidant Response Element (ARE)-Mediated Heme Oxygenase-1 (HO-1) Expression

  2008cites this paper
• Polyamine metabolism and transforming growth factor-beta signaling are affected in Caco-2 cells by differentially cooked broccoli extracts.

  2008cites this paper
• Protection of S-adenosyl methionine against the toxicity of clivorine on hepatocytes.

  2008cites this paper
• [Cancer chemopreventive agents: glucosinolates and their decomposition products in white cabbage (Brassica oleracea var. capitata)].

  2008cites this paper
• Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation.

  2008cites this paper
• Nrf2‐mediated induction of detoxifying enzymes by alantolactone present in Inula helenium

  2008cites this paper
• Physiological effects of broccoli consumption

  2008cites this paper