Conservation of PDX-1 structure, function, and expression in zebrafish.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Endocrinology

• Publication date

  1998-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ENDO.139.3.5768PMID 9492081
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional characterization of the transactivation properties of the PDX-1 homeodomain protein

  1997influential reference
• The β cell transcription factors and development of the pancreas

  1997cited by this paper
• The beta cell transcription factors and development of the pancreas.

  1997cited by this paper
• Functional characterization of the trout insulin promoter: implications for fish as a favorable model of pancreas development

  1997cited by this paper
• Mutations affecting development of zebrafish digestive organs.

  1996cited by this paper
• Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene.

  1996cited by this paper
• PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

  1996cited by this paper
• The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.

  1996cited by this paper
• Isolation, Characterization, and Chromosomal Mapping of the Human Insulin Promoter Factor 1 (IPF-1) Gene

  1996cited by this paper
• Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8.

  1995cited by this paper
• Appearance of insulin-like growth factor mRNA in the liver and pyloric ceca of a teleost in response to exogenous growth hormone.

  1995cited by this paper
• The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site.

  1995cited by this paper
• The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

  1995cited by this paper
• Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.

  1995cited by this paper
• XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

  1994cited by this paper
• Insulin-promoter-factor 1 is required for pancreas development in mice

  1994cited by this paper
• Zebrafish: genetic tools for studying vertebrate development.

  1994cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes.

  1994cited by this paper
• IDX‐1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

  1994cited by this paper
• Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.

  1994cited by this paper
• Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

  1993cited by this paper
• IPF1, a homeodomain‐containing transactivator of the insulin gene.

  1993cited by this paper
• Endocrine cells and nerves in the pyloric ceca and the intestine of Oncorhynchus mykiss (Teleostei): an immunocytochemical study.

  1992cited by this paper
• Peptides related to insulin-like growth factor 1 in the gastro-entero-pancreatic system of bony and cartilaginous fish.

  1992cited by this paper
• Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells.

  1991cited by this paper
• Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic α- and β-Cells

  1991cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radi

  1989cited by this paper
• XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of endoderm.

  1989cited by this paper
• Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

  1988cited by this paper
• Structure and neural expression of a zebrafish homeobox sequence.

  1988cited by this paper
• Aristotle revisited: the function of pyloric caeca in fish.

  1986cited by this paper
• RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon

  1985cited by this paper
• Carp preproinsulin cDNA sequence and evolution of insulin genes

  1983cited by this paper
• Fishes: An Introduction to Ichthyology

  1982cited by this paper
• Pancreatic endocrine cells of Barbus conchonius (Teleostei, Cyprinidae), and their relation to the enteroendocrine cells

  1979cited by this paper
• The development of the carp, cyprinus carpio. II. The development of the liver‐pancreas, the Islands of langerhans, and the spleen

  1933cited by this paper

• Molecular and Functional Divergence of Zebrafish Sox Paralogs Controlling Endoderm Formation and Left–Right Patterning

  2025cites this paper
• Understanding laterality disorders and the left-right organizer: Insights from zebrafish

  2022cites this paper
• A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes

  2022cites this paper
• Bioactive Phytochemicals Isolated from Akebia quinata Enhances Glucose-Stimulated Insulin Secretion by Inducing PDX-1

  2020cites this paper
• Endocrine Systems

  2020cites this paper
• Duplication and diversification of insulin genes in ray-finned fish

  2019cites this paper
• Study of human regulatory mutations associated with pancreatic diseases by humanizing the zebrafish genome.

  2019cites this paper
• Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish.

  2019cites this paper
• A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development

  2019cites this paper
• The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism

  2018cites this paper
• Sweet fish: Fish models for the study of hyperglycemia and diabetes

  2018cites this paper
• Zebrafish Pancreas Development and Regeneration: Fishing for Diabetes Therapies.

  2017cites this paper
• In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors

  2017cites this paper
• Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.

  2016cites this paper
• The evolution and regulation of the chordate ParaHox cluster

  2016cites this paper
• Study of the role of Pax 6 b and CREB signaling on pancreas differentiation in zebrafish ( Danio rerio )

  2015cites this paper
• Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment

  2015cites this paper
• Fishing for Nature's Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products

  2015cites this paper
• Functional analysis of human enhancers using the zebrafish embryo

  2014cites this paper
• Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway.

  2014cites this paper
• Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing

  2014cites this paper
• Aldh1-Expressing Endocrine Progenitor Cells Regulate Secondary Islet Formation in Larval Zebrafish Pancreas

  2013cites this paper
• High resolution whole mount in situ hybridization within zebrafish embryos to study gene expression and function.

  2013cites this paper
• Development of a Novel Pck-1: eGFP Reporter Zebrafish Line for the Discovery and Evaluation of Potential Anti-Diabetic Drugs

  2013cites this paper
• Translating Discovery in Zebrafish Pancreatic Development to Human Pancreatic Cancer: Biomarkers, Targets, Pathogenesis, and Therapeutics

  2013cites this paper
• Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish

  2013cites this paper
• odd‐skipped related 2 is required for fin chondrogenesis in zebrafish

  2013cites this paper
• DYX1C1 is required for axonemal dynein assembly and ciliary motility

  2013cites this paper
• Pegasus, the 'atypical' Ikaros family member, influences left-right asymmetry and regulates pitx2 expression.

  2013cites this paper
• Tbl3 regulates cell cycle length during zebrafish development.

  2012cites this paper
• DEAD-Box Protein Ddx46 Is Required for the Development of the Digestive Organs and Brain in Zebrafish

  2012cites this paper
• CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms

  2012cites this paper
• Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration.

  2012cites this paper
• Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression

  2012cites this paper
• Essential roles of zebrafish bmp 2 a , fgf 10 and fgf 24 in the specification of the ventral pancreas running title : role of BMP & FGF in pancreas formation

  2012cites this paper
• Pdx1 Is Post-Translationally Modified In vivo and Serine 61 Is the Principal Site of Phosphorylation

  2012cites this paper
• Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas

  2012cites this paper
• The Cdc14B phosphatase contributes to ciliogenesis in zebrafish

  2011cites this paper
• The Cdc14B phosphatase contributes to ciliogenesis in zebrafish

  2011cites this paper
• New insights into the signaling system and function of insulin in fish.

  2011cites this paper
• Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells.

  2010cites this paper
• Conservation of ParaHox genes' function in patterning of the digestive tract of the marine gastropod Gibbula varia

  2010cites this paper
• Parallel Retention of Pdx2 Genes in Cartilaginous Fish and Coelacanths

  2010cites this paper
• Dachshund homologues play a conserved role in islet cell development.

  2010cites this paper
• Endocrinology of zebrafish: A small fish with a large gene pool

  2010cites this paper
• Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

  2010cites this paper
• The Pax6b Homeodomain Is Dispensable for Pancreatic Endocrine Cell Differentiation in Zebrafish*

  2010cites this paper
• Zebrafish pancreas development.

  2009cites this paper
• Features of the ancestral bilaterian inferred from Platynereis dumerilii ParaHox genes

  2009cites this paper
• On the diabetic menu: Zebrafish as a model for pancreas development and function

  2009cites this paper
• Fgf4 is required for left-right patterning of visceral organs in zebrafish.

  2009cites this paper
• More constraint on ParaHox than Hox gene families in early metazoan evolution.

  2009cites this paper
• Regeneration of the Pancreas in Adult Zebrafish

  2009cites this paper
• Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning

  2009cites this paper
• Generation of living color transgenic zebrafish to trace somatostatin-expressing cells and endocrine pancreas organization.

  2009cites this paper
• Cyp26 enzymes function in endoderm to regulate pancreatic field size

  2009cites this paper
• Endoderm Patterning in Zebrafish: Pancreas Development: A Dissertation

  2009cites this paper
• Zebrafish: a complete animal model for in vivo drug discovery and development.

  2009cites this paper
• Organ-specific requirements for Hdac1 in liver and pancreas formation

  2008cites this paper
• Cdx4 is required in the endoderm to localize the pancreas and limitβ -cell number

  2008cites this paper
• Analisi in vivo dello sviluppo del pancreas di zebrafish

  2008cites this paper
• Exdpf Is a Key Regulator of Exocrine Pancreas Development Controlled by Retinoic Acid and ptf1a in Zebrafish

  2008cites this paper
• Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation

  2008cites this paper
• Cdx4 is required in the endoderm to localize the pancreas and limit (cid:2) -cell number

  2008cites this paper
• Ribosomal protein S 19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p 53 protein family

  2008cites this paper
• protein family abnormalities and defective erythropoiesis through activation of p53 Ribosomal protein S19 deficiency in zebrafish leads to developmental

  2008cites this paper
• Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family.

  2008cites this paper
• Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw

  2007cites this paper
• New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia

  2007cites this paper
• siRNA specific to Pdx-1 disturbed the formation of the islet in early zebrafish embryos

  2007cites this paper
• Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish.

  2007cites this paper
• Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase as a marker for exposure to anti-diabetic compounds.

  2007cites this paper
• Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development

  2007cites this paper
• The zebrafish model: use in studying cellular mechanisms for a spectrum of clinical disease entities.

  2007cites this paper
• Calsenilin is required for endocrine pancreas development in zebrafish

  2007cites this paper
• Bmp and Fgf signaling are essential for liver specification in zebrafish

  2007cites this paper
• A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.

  2007cites this paper
• Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling.

  2006cites this paper
• Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter.

  2006cites this paper
• Ontogeny of the endocrine pancreatic cells of the gilthead sea bream, Sparus aurata (Teleost).

  2006cites this paper
• A mutation in the zebrafish Na,K‐ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left‐right asymmetry downstream or in parallel to nodal flow

  2006cites this paper
• Fishing for gene function--endocrine modelling in the zebrafish.

  2006influential citation
• The Location and Temporal Expression of Foxa3 in the Developing Zebrafish Pancreas

  2006cites this paper
• All the three ParaHox genes are present in Nuttallochiton mirandus (Mollusca: polyplacophora): evolutionary considerations.

  2006cites this paper
• Early developmental expression of two insulins in zebrafish (Danio rerio).

  2006cites this paper
• Genetic analysis of early endocrine pancreas formation in zebrafish.

  2006cites this paper
• Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX‐1

  2006cites this paper
• sox4b is a key player of pancreatic alpha cell differentiation in zebrafish.

  2005cites this paper
• Genomic, cDNA and embryonic expression analysis of zebrafish IRF6, the gene mutated in the human oral clefting disorders Van der Woude and popliteal pterygium syndromes.

  2005cites this paper
• Zebrafish as a model for pancreatic cancer research.

  2005cites this paper
• Wnt5 signaling in vertebrate pancreas development

  2005cites this paper
• Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas.

  2004cites this paper
• Molecular mechanisms governing primordial germ cell migration in zebrafish

  2004cites this paper
• A second insulin gene in fish genomes.

  2004cites this paper
• PDX-1 and the Pancreas

  2004cites this paper
• Pancreas development in zebrafish.

  2004cites this paper
• Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: Liver, intestine, and exocrine pancreas

  2004influential citation
• A conserved role for retinoid signaling in vertebrate pancreas development

  2004influential citation
• Vegfc is required for vascular development and endoderm morphogenesis in zebrafish

  2004cites this paper
• Zebrafish mnx genes in endocrine and exocrine pancreas formation.

  2004cites this paper