Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neurones

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Pflügers Archiv

• Publication date

  1999-07-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s004240050907PMID 10398853
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  1998cited by this paper
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• Intracellular pH Regulation in Bovine Aortic Endothelial Cells: Evidence of Both Na+/H+ Exchange and Na+-Dependent Cl–/HCO–3 Exchange

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• CO2‐sensitive medullary neurons: activation by intracellular acidification

  1998cited by this paper
• Intracellular pH regulation in bovine aortic endothelial cells: evidence of both Na+/H+ exchange and Na+-dependent Cl-/HCO3- exchange.

  1998cited by this paper
• S3226, a novel inhibitor of Na+/H+ exchanger subtype 3 in various cell types

  1998cited by this paper
• Intracellular pH response to hypercapnia in neurons from chemosensitive areas of the medulla.

  1997cited by this paper
• Molecular physiology of vertebrate Na+/H+ exchangers.

  1997cited by this paper
• The Na+/H+ exchange isoform NHE3 regulates basal canine ileal Na+ absorption in vivo.

  1997cited by this paper
• Expression and localization of Na+/H+ exchangers in rat central nervous system.

  1997cited by this paper
• Role of the NHE3 isoform of the Na+/H+ exchanger in sodium absorption by the rabbit gallbladder

  1996cited by this paper
• Decreased energy metabolism in brain stem during central respiratory depression in response to hypoxia.

  1996cited by this paper
• Chemosensitive medullary neurones in the brainstem‐‐spinal cord preparation of the neonatal rat.

  1996cited by this paper
• A fluorescence technique to measure intracellular pH of single neurons in brainstem slices.

  1996influential reference
• DAPAS, a computerised workplace for Digital Acquisition and Processing of Analog Signals, with up to two gigabytes data per registration.

  1996cited by this paper
• Role of NHE3 in Mediating Renal Brush Border Na+-H+ Exchange

  1996cited by this paper
• Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney.

  1996cited by this paper
• Superiority of in vitro over in vivo calibrations of BCECF in vascular smooth muscle cells

  1996cited by this paper
• Rhythm generation in organotypic medullary cultures of newborn rats

  1995cited by this paper
• Effects of inhibitors of enzymatic and cellular pH-regulating systems on central sympathetic chemosensitivity

  1995cited by this paper
• Cisternal Na+ transport inhibition and the ventilatory response to CO2.

  1994cited by this paper
• Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger.

  1993cited by this paper
• NHE3: a Na+/H+ exchanger isoform of renal brush border.

  1993cited by this paper
• Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.

  1993cited by this paper
• Is central chemoreceptor sensitive to intracellular rather than extracellular pH?

  1990cited by this paper
• Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

  1989cited by this paper
• A procedure for culturing rat neocortex explants in a serum-free nutrient medium.

  1988cited by this paper
• Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

  1982influential reference
• Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture.

  1979influential reference
• Discharge patterns of brain-stem respiratory neurons in relation to carbon dioxide tension.

  1968cited by this paper

• Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism – Update to the Human Model and Expansion of Applications

  2020influential citation
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  2019cites this paper
• Central Chemosensitivity, Sleep, and Wakefulness

  2018cites this paper
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  2016cites this paper
• Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease.

  2016cites this paper
• Exchange Activity in Taste Receptor Cells + -H + Na

  2015cites this paper
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  2015cites this paper
• Inhibition of central Na+/H+ exchanger type 3 can alleviate sleep apnea in Sprague‐Dawley rats

  2014cites this paper
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  2014cites this paper
• Intracellular pH regulation by acid-base transporters in mammalian neurons

  2014influential citation
• The adrenergic regulation of proximal tubular Na+/H+ exchanger 3 in the rat

  2014cites this paper
• SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.

  2013cites this paper
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  2013cites this paper
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  2011cites this paper
• Capacity for intracellular pH compensation during hypercapnia in white sturgeon primary liver cells

  2011cites this paper
• Na+/H+ exchangers.

  2011cites this paper
• CO2 chemoreception in cardiorespiratory control.

  2010influential citation
• Central CO 2 Chemoreception in Cardiorespiratory Control CO 2 chemoreception in cardiorespiratory control

  2010influential citation
• Systemic inhibition of the Na(+)/H (+) exchanger type 3 in intact rats activates brainstem respiratory regions.

  2009cites this paper
• pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats.

  2009cites this paper
• Respiratory response to systemic inhibition of the Na+/H+ exchanger type 3 in intact rats.

  2009cites this paper
• The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat.

  2008cites this paper
• University of Warwick institutional repository: http://go

  2008cites this paper
• NHE3 in the human brainstem: implication for the pathogenesis of the sudden infant death syndrome (SIDS)?

  2008cites this paper
• Respiratory chemoreceptor function in vertebrates comparative and evolutionary aspects.

  2007cites this paper
• Wirkungen subtyp-spezifischer Inhibitoren des Natrium-Protonen-Austauschers auf den Atemrhythmus

  2007cites this paper
• Role of brainstem sodium/proton exchanger 3 for breathing control during chronic acid base imbalance.

  2007cites this paper
• Deciphering the mechanisms of intestinal imino (and amino) acid transport: the redemption of SLC36A1.

  2007cites this paper
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  2007cites this paper
• Regulation of intestinal hPepT 1 ( SLC 15 A 1 ) activity by phosphodiesterase inhibitors is via inhibition of NHE 3 ( SLC 9 A 3 )

  2007cites this paper
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  2006cites this paper
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  2005cites this paper
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  2005cites this paper
• Evolutionary origins of eukaryotic sodium/proton exchangers.

  2005cites this paper
• Na+-H+ exchange activity in taste receptor cells.

  2004cites this paper
• H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.

  2004cites this paper
• Ritucci in chemosensitive neurons and acid signaling 2 Cellular mechanisms involved in CO

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
• [Central chemoreceptors and sudden infant death syndrome].

  2004cites this paper
• NHE3 inhibition activates duodenal bicarbonate secretion in the rat.

  2004influential citation
• Brainstem NHE-3 expression and control of breathing.

  2004cites this paper
• Inhibition of intestinal dipeptide transport by the neuropeptide VIP is an anti‐absorptive effect via the VPAC1 receptor in a human enterocyte‐like cell line (Caco‐2)

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• Phylogeny of central CO2/pH chemoreception in vertebrates

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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper