The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular Biology of the Cell

• Publication date

  2002-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E02-02-0103PMID 12181353PMCID PMC117949
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SH 2 Domains Recognize Specific Phosphopeptide Sequences

  2004cited by this paper
• FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition.

  2001cited by this paper
• The Role of Tyrosine Residues in Fibroblast Growth Factor Receptor 1 Signaling in PC12 Cells

  2001cited by this paper
• Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells.

  2000cited by this paper
• FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors

  2000cited by this paper
• p38 Mitogen-activated Protein Kinase Activation Is Required for Fibroblast Growth Factor-2-stimulated Cell Proliferation but Not Differentiation*

  1999cited by this paper
• Requirement of the Src Homology 2 Domain Protein Shb for T Cell Receptor-dependent Activation of the Interleukin-2 Gene Nuclear Factor for Activation of T Cells Element in Jurkat T Cells*

  1999cited by this paper
• Fibroblast Growth Factor Receptor-1-mediated Endothelial Cell Proliferation Is Dependent on the Src Homology (SH) 2/SH3 Domain-containing Adaptor Protein Crk*

  1999influential reference
• Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C , phospholipase D , phospholipase A 2 , phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells

  1999cited by this paper
• Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

  1998cited by this paper
• Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

  1998cited by this paper
• Lipid metabolism in fibroblast growth factor-stimulated L6 myoblasts: a receptor mutation (Y766F) abrogates phospholipase D and diacylglycerol kinase activities.

  1998cited by this paper
• Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase*

  1998influential reference
• Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

  1998influential reference
• Crystal structure of the tyrosine phosphatase SHP-2.

  1998cited by this paper
• The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells.

  1998influential reference
• Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins*

  1998influential reference
• Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins

  1998cited by this paper
• Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding

  1998cited by this paper
• Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

  1998cited by this paper
• Lipid metabolism in fibroblast growth factor-stimulated L6 myoblasts: a receptor mutation (Y766F) abrogates phospholipase D and diacylglycerol kinase activities.

  1998cited by this paper
• A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.

  1997cited by this paper
• cAMP‐dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation

  1997cited by this paper
• Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

  1997influential reference
• Fibroblast growth factor receptor 1-induced differentiation of endothelial cell line established from tsA58 large T transgenic mice.

  1996influential reference
• Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 engages binding to Grb2 via tyrosine 584.

  1996cited by this paper
• Cell cycle-dependent activation of Ras.

  1996cited by this paper
• Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb.

  1996cited by this paper
• Reduced Activation of RAF-1 and MAP Kinase by a Fibroblast Growth Factor Receptor Mutant Deficient in Stimulation of Phosphatidylinositol Hydrolysis (*)

  1995influential reference
• Shc and a Novel 89-kDa Component Couple to the Grb2-Sos Complex in Fibroblast Growth Factor-2-stimulated Cells (*)

  1995cited by this paper
• PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

  1995influential reference
• Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.

  1995influential reference
• Phospholipid signaling.

  1995cited by this paper
• Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis.

  1994cited by this paper
• Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.

  1994cited by this paper
• Shb is a ubiquitously expressed Src homology 2 protein.

  1994influential reference
• SH2 domains recognize specific phosphopeptide sequences.

  1993cited by this paper
• Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

  1993cited by this paper
• Production of high-titer helper-free retroviruses by transient transfection.

  1993cited by this paper
• Inhibition by cAMP of Ras-dependent activation of Raf.

  1993influential reference
• Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.

  1992cited by this paper
• Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

  1992cited by this paper
• Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

  1992influential reference
• The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

  1991cited by this paper
• A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

  1991cited by this paper
• Regulation of bombesin-stimulated inositol 1,4,5-trisphosphate generation in Swiss 3T3 fibroblasts by a guanine-nucleotide-binding protein.

  1990cited by this paper
• Signal transduction by receptors with tyrosine kinase activity.

  1990cited by this paper

• The mechanism by which FGF23/FGFR-1 activates NOX2-ROS in vascular endothelial cells in the context of severe heat stroke-induced acute lung injury

  2025cites this paper
• EphA2 regulates vascular permeability and prostate cancer metastasis via modulation of cell junction protein phosphorylation

  2024cites this paper
• Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium

  2023cites this paper
• FGF18.

  2023cites this paper
• Potential roles of FGF5 as a candidate therapeutic target in prostate cancer.

  2023cites this paper
• Elimination of endogenous high molecular weight FGF2 prevents pressure-overload-induced systolic dysfunction, linked to increased FGFR1 activity and NR1D1 expression

  2021cites this paper
• The canonical FGF-FGFR signaling system at the molecular level

  2021cites this paper
• Biological Significance and Targeting of the FGFR Axis in Cancer

  2021cites this paper
• Fibroblast Growth Factor in Diabetic Foot Ulcer: Progress and Therapeutic Prospects

  2021cites this paper
• Molecular and genetic studies in high-risk neuroblastoma

  2021cites this paper
• FGFR regulation of dendrite elaboration in adult-born granule cells depends on intracellular mediator and proximity to the soma.

  2020cites this paper
• TAS‐120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

  2019cites this paper
• Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

  2019cites this paper
• TAS-120 covalent complex with FGFR1

  2019cites this paper
• Establishment of a three-dimensional model to study human uterine angiogenesis

  2018cites this paper
• MAPK and PI3K signaling: At the crossroads of neural crest development.

  2018cites this paper
• Editors’ note: Novel ocular toxicity associated with fibroblast growth factor receptor (FGFR) inhibitors in cancer treatment: observational case series

  2017cites this paper
• SH2 domain–containing adaptor protein B expressed in dendritic cells is involved in T-cell homeostasis by regulating dendritic cell–mediated Th2 immunity

  2017cites this paper
• MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC

  2016cites this paper
• SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways

  2016cites this paper
• Les récepteurs venus kinase (VKRs) de schistosoma mansoni : étude des voies de signalisation de SmVKR1 et rôle de la protéine adaptatrice SmShb

  2016cites this paper
• Genetic insights into the mechanisms of Fgf signaling

  2016cites this paper
• The role of the Src Homology-2 domain containing protein B (SHB) in β cells.

  2016cites this paper
• Focal adhesion kinase (FAK1) regulates SHB phosphorylation and its binding with a range of signaling proteins.

  2016cites this paper
• The impact of polyphenols on chondrocyte growth and survival: a preliminary report

  2015cites this paper
• The FGFR Inhibitor NVP-BGJ398 Induces NSCLC Cell Death by Activating Caspase-dependent Pathways as well as Caspase-independent Apoptosis.

  2015cites this paper
• EFFECTS OF FYN-RELATED-KINASE ACTIVITY ON BREAST CANCER CELL PROLIFERATION, MIGRATION, INVASION AND COLONY FORMATION

  2015cites this paper
• The Fibroblast Growth Factor signaling pathway

  2015cites this paper
• The involvement of phosphoinositide 3-kinase in murine lung branching morphogenesis and insights into protein mediated drug delivery

  2014cites this paper
• Biological Markers of Fertility

  2014cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1048 Biological Markers of Fertility

  2014cites this paper
• The Signaling Adapter, FRS2, Facilitates Neuronal Branching in Primary Cortical Neurons via Both Grb2- and Shp2-Dependent Mechanisms

  2014cites this paper
• Phosphorylation of Serine 779 in Fibroblast Growth Factor Receptor 1 and 2 by Protein Kinase Cϵ Regulates Ras/Mitogen-activated Protein Kinase Signaling and Neuronal Differentiation*

  2013cites this paper
• Consequences of Shb Deficiency on Hematopoietic Cell Function

  2013cites this paper
• The LMP2A protein of Epstein-Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases.

  2013cites this paper
• Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers

  2013influential citation
• SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome

  2012cites this paper
• Heterogeneity among RIP‐Tag2 insulinomas allows vascular endothelial growth factor‐A independent tumor expansion as revealed by studies in Shb mutant mice: Implications for tumor angiogenesis

  2012cites this paper
• Phospho-Signaling at Oocyte Maturation and Fertilization: Set Up for Embryogenesis and Beyond Part II. Kinase Regulators and Substrates

  2012influential citation
• Fibronectin Induces Endothelial Cell Migration through β1 Integrin and Src-dependent Phosphorylation of Fibroblast Growth Factor Receptor-1 at Tyrosines 653/654 and 766*

  2012cites this paper
• FGFs: Neurodevelopment’s Jack-of-all-Trades – How Do They Do it?

  2011cites this paper
• Embryonic Stem Cells as a Model System to Elucidate Early Events in Cardiac Specification and Determination

  2011cites this paper
• Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation).

  2011cites this paper
• Signalling pathways that regulate endothelial differentiation from stem cells.

  2011cites this paper
• lymphoma that subsequently progressed to AML mediated through PI3-K in a T-cell TEL-FGFR3 Transforming property of

  2010cites this paper
• Signaling from Fibroblast Growth Factor Receptors in Development and Disease

  2010cites this paper
• SH2B1--the adaptor protein that could.

  2010cites this paper
• Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo.

  2010cites this paper
• De-regulated FGF receptors as therapeutic targets in cancer.

  2010cites this paper
• Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries.

  2010cites this paper
• Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer

  2010cites this paper
• Supresión de la angiogénesis tumoral a través de anticuerpos monoclonales

  2010cites this paper
• Role of Rap1 in angiogenesis and tumor invasion

  2009influential citation
• Prostaglandin E2 Primes the Angiogenic Switch via a Synergic Interaction With the Fibroblast Growth Factor-2 Pathway

  2009cites this paper
• Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish

  2009cites this paper
• SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.

  2009cites this paper
• Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth.

  2009cites this paper
• Fibroblast growth factor receptor-1 phosphorylation requirement for cardiomyocyte differentiation in murine embryonic stem cells

  2009cites this paper
• Non-canonical fibroblast growth factor signalling in angiogenesis.

  2008cites this paper
• Formation of Composite Endothelial Cell–Mesenchymal Stem Cell Islets

  2008cites this paper
• Interdependent fibroblast growth factor and activin A signaling promotes the expression of endodermal genes in differentiating mouse embryonic stem cells expressing Src Homology 2-domain inactive Shb.

  2008cites this paper
• Rap1a Is a Key Regulator of Fibroblast Growth Factor 2-Induced Angiogenesis and Together with Rap1b Controls Human Endothelial Cell Functions

  2008cites this paper
• Fibroblast Growth Factor Receptor 2 Phosphorylation on Serine 779 Couples to 14-3-3 and Regulates Cell Survival and Proliferation

  2008cites this paper
• P2Y receptors activated by diadenosine polyphosphates reestablish Ca(2+) transients in achondroplasic chondrocytes.

  2008cites this paper
• Fibroblast Growth Factor-2 in Angiogenesis

  2008cites this paper
• The role of Shb in ES cell differentiation, angiogenesis and tumor growth

  2008cites this paper
• Bisindolylmaleimide I Suppresses Fibroblast Growth Factor-mediated Activation of Erk MAP Kinase in Chondrocytes by Preventing Shp2 Association with the Frs2 and Gab1 Adaptor Proteins*

  2007cites this paper
• Synergistic anti-tumor effect of recombinant chicken fibroblast growth factor receptoreate eate ant angogeness anlowose gectabnen aouse colon aenocarcnoaoel

  2007cites this paper
• Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells

  2007influential citation
• Enhanced efficacy in anti-tumour activity by combined therapy of recombinant FGFR-1 related angiogenesis and low-dose cytotoxic agent.

  2007cites this paper
• Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies.

  2007cites this paper
• Phospholipase D1 activation through Src and Ras is involved in basic fibroblast growth factor‐induced neurite outgrowth of H19‐7 cells

  2007influential citation
• Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero

  2007cites this paper
• The role and mechanism of fibroblast growth factor receptor 2 in cellular transformation

  2007cites this paper
• Synergistic anti-tumor effect of recombinant chicken fibroblast growth factor receptor-1-mediated anti-angiogenesis and low-dose gemcitabine in a mouse colon adenocarcinoma model.

  2007cites this paper
• Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development

  2006cites this paper
• Anti-diabetic and beta-cell protective actions of imatinib mesylate.

  2006cites this paper
• The Role of the SHB Adapter Protein in Cell Differentiation and Development

  2006cites this paper
• The SHB Adapter Protein Is Required for Normal Maturation of Mesoderm during in Vitro Differentiation of Embryonic Stem Cells*

  2006cites this paper
• Fibroblast growth factor 2 applied to the optic nerve after axotomy up‐regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways

  2006cites this paper
• Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization.

  2006cites this paper
• Ligand concentration is a driver of divergent signaling and pleiotropic cellular responses to FGF

  2006cites this paper
• Signal transduction in angiogenesis.

  2005cites this paper
• Mechanisms of Angiogenesis

  2005cites this paper
• Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis.

  2005cites this paper
• Development of Novel Therapy for Achondroplasia: Use of Parathyroid Hormone

  2005cites this paper
• Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor-2 and platelet-derived growth factor receptor-beta signaling.

  2005cites this paper
• Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML.

  2005cites this paper
• Fibroblast Growth Factor Receptor-1 Expression Is Required for Hematopoietic but not Endothelial Cell Development

  2005cites this paper
• Tyrosine Hydroxylase Induction by Basic Fibroblast Growth Factor and Cyclic AMP Analogs in Striatal Neural Stem Cells: Role of ERK1/ERK2 Mitogen-activated Protein Kinase and Protein Kinase C

  2004cites this paper
• Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1318 The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

  2004cites this paper
• Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML

  2004cites this paper
• Roles of main pro- and anti-angiogenic factors in tumor angiogenesis.

  2004cites this paper
• Signaling, internalization, and intracellular activity of fibroblast growth factor.

  2004cites this paper
• EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

  2004cites this paper
• The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration*

  2004cites this paper
• The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation.

  2003cites this paper
• Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1270 Roles of the Shb and Cbl Proteins in Signal Transduction and Blood Vessel Formation

  2003cites this paper
• Local factors regulating growth and function of human thyroid cells in vitro and in vivo.

  2003cites this paper
• Heparan sulfate regulation of fibroblast growth factor (FGF) receptor-1 signal transduction.

  2003influential citation