REGULATION OF LYMPHOCYTE RESPONSES IN VITRO

DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T-deprived spleen. We conclude that two mechanisms of suppression are at work: a direct effect of macrophages and a macrophage-dependent "suppressor T cell" effect.

• Publication year

  1972

• Venue

  Journal of Experimental Medicine

• Publication date

  1972-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.136.4.956PMID 4560346PMCID 2139268
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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