Natural products for glycaemic control: Polyphenols as inhibitors of alpha-amylase

Abstract Background α-Amylase plays an important role in starch digestion, the main source of exogenous glucose in the human diet. Retarding glucose absorption through delaying digestion of starchy foods by inhibiting α-amylase in the digestive tract has potential as a management and/or therapeutic approach to type II diabetes. Polyphenols have been reported to have inhibitory activity against the enzyme. Scope and approach This review provides an overview of structure-activity relationships of dietary polyphenols inhibiting α-amylase and the underlying mechanisms. The methods applied to characterize binding interactions between polyphenols and α-amylase, as well as the relationships between the constants obtained from these methods are discussed. As polyphenols can interact with both polysaccharides and α-amylase, the potential effects of polysaccharides on the binding of polyphenols with α-amylase are also summarised. Key findings and conclusions The inhibition of α-amylase by polyphenols results from binding interactions between the enzyme and polyphenols. The galloyl moiety in polyphenols plays an important role. IC50, inhibition kinetics, fluorescence quenching, differential scanning calorimetry, isothermal titration calorimetry and molecular docking can be comprehensively combined to analyze the binding interactions, as the constants obtained from these methods can be correlated. Soluble polysaccharides may reduce the binding and inhibitory action of polyphenols against α-amylase. Most work reported in this review is from in vitro studies, so if and how the binding interactions affect starch digestion in vivo need to be further studied.

• Publication year

  2019

• Venue

  Trends in Food Science & Technology

• Publication date

  2019-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/J.TIFS.2019.07.009
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The involvement of phenolic-rich extracts from Galician autochthonous extra-virgin olive oils against the α-glucosidase and α-amylase inhibition.

  2019cited by this paper
• Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

  2018cited by this paper
• Corrigendum to "Interactions between polyphenols in thinned young apples and porcine pancreatic α-amylase: Inhibition, detailed kinetics and fluorescence quenching" [Food Chem. 208 (2016) 51-60].

  2018cited by this paper
• Inhibition studies on α-amylase using isothermal titration calorimetry

  2018cited by this paper
• Study on interaction between human salivary α-amylase and sorghum procyanidin tetramer: Binding characteristics and structural analysis.

  2018cited by this paper
• Dietary polyphenols and type 2 diabetes: Human Study and Clinical Trial

  2018cited by this paper
• In Vitro and In Vivo Inhibition of Intestinal Glucose Transport by Guava (Psidium Guajava) Extracts

  2018cited by this paper
• Inhibition of α-glucosidase and α-amylase by flavonoid glycosides from Lu'an GuaPian tea: molecular docking and interaction mechanism.

  2018cited by this paper
• Investigation the interaction between procyanidin dimer and α-amylase: Spectroscopic analyses and molecular docking simulation.

  2018cited by this paper
• Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response

  2018cited by this paper
• Do marine algal polyphenols have antidiabetic, antihyperlipidemic or anti-inflammatory effects in humans? A systematic review

  2018cited by this paper
• Soluble polysaccharides reduce binding and inhibitory activity of tea polyphenols against porcine pancreatic α-amylase

  2018cited by this paper
• The Mechanisms of Alpha-Amylase Inhibition by Flavan-3-Ols and the Possible Impacts of Drinking Green Tea on Starch Digestion.

  2018cited by this paper
• Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins

  2017cited by this paper
• Green and Chamomile Teas, but not Acarbose, Attenuate Glucose and Fructose Transport via Inhibition of GLUT2 and GLUT5.

  2017cited by this paper
• Inhibition study of red rice polyphenols on pancreatic α-amylase activity by kinetic analysis and molecular docking

  2017cited by this paper
• Interactions between polyphenols and polysaccharides: Mechanisms and consequences in food processing and digestion

  2017cited by this paper
• Inhibitory effect of chlorogenic acid on digestion of potato starch.

  2017cited by this paper
• The mechanism of interactions between tea polyphenols and porcine pancreatic alpha‐amylase: Analysis by inhibition kinetics, fluorescence quenching, differential scanning calorimetry and isothermal titration calorimetry

  2017cited by this paper
• Interactions between polyphenols in thinned young apples and porcine pancreatic α-amylase: Inhibition, detailed kinetics and fluorescence quenching.

  2016cited by this paper
• 3 or 3’-Galloyl substitution plays an important role in association of catechins and theaflavins with porcine pancreatic α-amylase: The kinetics of inhibition of α-amylase by tea polyphenols

  2016cited by this paper
• A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior*

  2016cited by this paper
• Changes of porcine pancreas α-amylase in activity and secondary conformations under inhibition of tea polyphenols

  2016cited by this paper
• Binding of an Oligomeric Ellagitannin Series to Bovine Serum Albumin (BSA): Analysis by Isothermal Titration Calorimetry (ITC).

  2015cited by this paper
• Interactions of polyphenols with carbohydrates, lipids and proteins.

  2015cited by this paper
• Interaction mechanism between green tea extract and human α-amylase for reducing starch digestion.

  2015cited by this paper
• The mechanism study in the interactions of sorghum procyanidins trimer with porcine pancreatic α-amylase.

  2015cited by this paper
• Four flavonoid compounds from Phyllostachys edulis leaf extract retard the digestion of starch and its working mechanisms.

  2014cited by this paper
• Effects of Oolong tea polyphenols, EGCG, and EGCG3″Me on pancreatic α-amylase activity in vitro.

  2014cited by this paper
• Neutral sugar side chains of pectins limit interactions with procyanidins.

  2014cited by this paper
• Characterization of binding interactions of (-)-epigallocatechin-3-gallate from green tea and lipase.

  2013cited by this paper
• Elucidation of structural difference in theaflavins for modulation of starch digestion

  2013cited by this paper
• Structure of flavones and flavonols. Part I: Role of substituents on the planarity of the system

  2013cited by this paper
• Critical Reviews in Food Science and Nutrition

  2013cited by this paper
• Inhibition of α-amylase and glucoamylase by tannins extracted from cocoa, pomegranates, cranberries, and grapes.

  2013cited by this paper
• Enhancement of the antioxidant activity of orange and lime juices by flavonoid enzymatic de-glycosylation

  2013cited by this paper
• A Review on Structure–Activity Relationship of Dietary Polyphenols Inhibiting α-Amylase

  2013cited by this paper
• Interactions between pectic compounds and procyanidins are influenced by methylation degree and chain length.

  2013cited by this paper
• Carbohydrates inhibit salivary proteins precipitation by condensed tannins.

  2012cited by this paper
• Isolation of a new phlorotannin, a potent inhibitor of carbohydrate-hydrolyzing enzymes, from the brown alga Sargassum patens.

  2012cited by this paper
• Changes in polyphenol and polysaccharide content of grape seed extract and grape pomace after enzymatic treatment.

  2012cited by this paper
• Interactions between Polyphenols and Macromolecules: Quantification Methods and Mechanisms

  2012cited by this paper
• Inhibitory effects of chlorogenic acids from green coffee beans and cinnamate derivatives on the activity of porcine pancreas α-amylase isozyme I

  2011cited by this paper
• Binding interactions of α-amylase with starch granules: The influence of supramolecular structure and surface area

  2011cited by this paper
• α-Glucosidase and α-Amylase Inhibitory Activity of Common Constituents from Traditional Chinese Medicine Used for Diabetes Mellitus

  2010cited by this paper
• α-Glucosidase and α-amylase inhibitory activities of guava leaves

  2010cited by this paper
• Interaction of 3'-O-caffeoyl D-quinic acid with human serum albumin.

  2009cited by this paper
• Study on the interaction between 3 flavonoid compounds and alpha-amylase by fluorescence spectroscopy and enzymatic kinetics.

  2009cited by this paper
• Mechanistic approach by which polysaccharides inhibit α-amylase/procyanidin aggregation.

  2009cited by this paper
• Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II.

  2009cited by this paper
• Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase.

  2008cited by this paper
• Interactions between flavan-3-ols and poly(L-proline) studied by isothermal titration calorimetry: effect of the tannin structure.

  2007cited by this paper
• Mechanism of inhibition of rice bran lipase by polyphenols: a case study with chlorogenic acid and caffeic acid.

  2007cited by this paper
• Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary alpha-amylase (HSA) by fluorescence quenching.

  2007cited by this paper
• Inhibition of alpha-glucosidase and alpha-amylase by flavonoids.

  2006cited by this paper
• Antioxidant and α-Amylase Inhibitory Compounds from Aerial Parts of Varthemia iphionoides Boiss

  2006cited by this paper
• Isothermal titration calorimetry study of epicatechin binding to serum albumin.

  2006cited by this paper
• Characterization by LC-MS(n) of four new classes of chlorogenic acids in green coffee beans: dimethoxycinnamoylquinic acids, diferuloylquinic acids, caffeoyl-dimethoxycinnamoylquinic acids, and feruloyl-dimethoxycinnamoylquinic acids.

  2006cited by this paper
• Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase.

  2005cited by this paper
• Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase

  2005cited by this paper
• Inhibitory effects of tannin on human salivary α-amylase

  2004cited by this paper
• Microencapsulation of capsaicin by the complex coacervation of gelatin, acacia and tannins

  2004cited by this paper
• Study of carbohydrate influence on protein–tannin aggregation by nephelometry

  2003cited by this paper
• Identification of Anti-α-Amylase Components from Olive Leaf Extracts

  2003cited by this paper
• Use of DSC to detect the heterogeneity of hydrothermal stability in the polyphenol-treated collagen matrix.

  2003cited by this paper
• New approach to stability assessment of protein solution formulations by differential scanning calorimetry.

  2003cited by this paper
• Effects of non-covalent interactions with 5-O-caffeoylquinic acid (chlorogenic acid) on the heat denaturation and solubility of globular proteins.

  2003cited by this paper
• Structural changes induced in bovine serum albumin by covalent attachment of chlorogenic acid

  2002cited by this paper
• The determinants of α-amylase pH–activity profiles

  2001cited by this paper
• Relationship of sequence and structure to specificity in the α-amylase family of enzymes

  2001cited by this paper
• Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid

  2000cited by this paper
• Production and biochemical characterization of an alpha-amylase from the moderate halophile Halomonas meridiana.

  2000cited by this paper
• Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition

  1999cited by this paper
• Characterization of a fungal amylase from Mucor sp. associated with the marine sponge Spirastrella sp.

  1998cited by this paper
• Structure and Molecular Model Refinement of Pig Pancreatic α-Amylase at 2·1 Å Resolution

  1993cited by this paper
• WHAT IF: a molecular modeling and drug design program.

  1990cited by this paper
• Kinetic study of the irreversible thermal denaturation of Bacillus licheniformis alpha-amylase.

  1989cited by this paper
• Three dimensional structure of porcine pancreatic alpha‐amylase at 2.9 A resolution. Role of calcium in structure and activity.

  1987cited by this paper
• REVERSAL BY PHENOLIC COMPOUNDS OF ABSCISIC ACID-INDUCED INHIBITION OF IN VITRO ACTIVITY OF AMYLASE FROM SEEDS OF TRITICUM AESTIVUM L.

  1986cited by this paper
• Selective expression of a probable amylase/protease inhibitor in barley aleurone cells: Comparison to the barley amylase/subtilisin inhibitor

  1986cited by this paper
• Statistical considerations in the estimation of enzyme kinetic parameters by the direct linear plot andother methods.

  1974cited by this paper
• Conformation Changes of Proteins

  1954cited by this paper
• The Determination of Enzyme Dissociation Constants

  1934cited by this paper

• Construction of a gelatinized starch-based chlorogenic acid emulsion: Transcriptomic insights into antibacterial mechanism and application in cod preservation

  2026cites this paper
• Inhibition effect of vitamin B6 on α-glucosidase and mechanism of its synergistic inhibition with liquiritigenin.

  2026cites this paper
• Lichen Parmotrema perlatum derived constituents as natural metabolic interveners: mechanistic insights based on integration of bioactivities, molecular docking and fuzzy logic to develop a functional green tea beverage.

  2026cites this paper
• Rheological, thermal, pasting, structural and in-vitro digestibility properties on complex of physically modified Kodo millet starch with quercetin.

  2026cites this paper
• Innovative strategies for producing diabetes-friendly cereal-based products: Mechanism, Application, and Challenges

  2026cites this paper
• Three Polyphenolic Compounds from Inonotus obliquus: Antioxidant Activity, Xanthine Oxidase Inhibition, and Regulatory Effects on MyD88/TLR4/NF-κB Pathway in MSU-Induced RAW 264.7 Macrophages.

  2026cites this paper
• Exploring the inhibitory mechanism of icaritin on α-glucosidase and synergistic effect with acarbose by inhibition kinetics, molecular docking, multi-spectroscopic methods and in vivo hypoglycemic model

  2026cites this paper
• Kinetic Analysis and Starch Digestion Product Composition Reveal the Subtle Relationship between the Anthocyanidin Structure and Inhibitory Activity on Pancreatic α-Amylase.

  2025cites this paper
• Revealing the inhibition mechanism of ultrasound-assisted purified dried apricot polyphenols on α-amylase: Insights from multispectral and computational analyses

  2025cites this paper
• Two novel phosvitin peptides FGTEPDAK and IWGR: The dual effects and associated mechanisms for inhibiting α-amylase and alleviating insulin resistance in IR-HepG2 cells.

  2025cites this paper
• Optimization of Extraction Process, Structural Characterization, and Antioxidant and Hypoglycemic Activity Evaluation of Polysaccharides From the Medicinal and Edible Plant: Cistanche deserticola Ma

  2025cites this paper
• Italian Biodiversity: A Source of Edible Plant Extracts with Protective Effects Against Advanced Glycation End Product-Related Diseases

  2025cites this paper
• Enhancing stability and catalytic activity of urate oxidase using natural deep eutectic solvent: insights from experimental and computational approaches.

  2025cites this paper
• Rice with a healthier glycaemic profile: Unveiling the molecular mechanisms and breeding strategies for the future.

  2025cites this paper
• Rice bran peptides with α-glucosidase inhibition activity delay the in vitro starch digestion of different rice foods.

  2025cites this paper
• Effect of Sugarcane Polyphenol Extract on α-Amylase Inhibition and Mechanism Exploration

  2025cites this paper
• Ultrasound-optimized phenolic recovery from feijoa (Acca sellowiana) peel: Cultivar variability, antioxidant capacity, and in vitro starch digestion.

  2025cites this paper
• Spectral analysis and computational simulation to investigate the synergistic mechanism of L-theanine and epigallocatechin gallate in inhibiting α-glucosidase activity.

  2025cites this paper
• Enzymatic resistance of starch-polyphenol inclusion complexes: polyphenol inhibition and structural changes during in vitro digestion.

  2025cites this paper
• The synergy between Empodisma minus and microbial enzymes in carbon storage and nutrient turnover in the peatlands of K’gari (Fraser Island), Australia

  2025cites this paper
• Electrospun Quercetin-Loaded PLA and PLA/Polyethylene Glycol Fibers: Preparation, Characterization, and In Vitro Evaluation

  2025cites this paper
• Inhibition effects of xanthohumol on α-amylase and α-glucosidase: Kinetics, multi-spectral and molecular docking.

  2025cites this paper
• The combination of epigallocatechin gallate with exopolysaccharides from Bacillus subtilis STB22 enhances α-amylase inhibitory activity.

  2025cites this paper
• Citrus sinensis enriched polyphenols loaded alginate microspheres: Characterization, stability, in vitro release, bio-accessibility, and biological activities.

  2025cites this paper
• Iodoquinoline-Biofortified Lettuce as a Safe and Bioavailable Dietary Iodine Source: In Vivo Study in Rats

  2025cites this paper
• Flavor perception and biological activities of bitter compounds in food.

  2025cites this paper
• Polyphenol -based controllable assembly platforms for reducing the risk of nonspecific adhesion in vivo for cancer therapy.

  2025cites this paper
• Pea starch complexation with lipids and phenolic compounds for enhanced resistant starch content

  2025cites this paper
• Applying Isothermal Titration Calorimetry and Saturation Transfer Difference-NMR to Study the Mode of Interaction of Flavan-3-ols with α-Amylase to Understand Their Impact on Starch Hydrolysis

  2025cites this paper
• Digestibility modulating and 3D printing of gliadin/resveratrol nanoparticle-filled starch gels.

  2025cites this paper
• Self-assembled cinnamon essential oil-coffee polyphenol colloidal dispersion integrated into oat milk: Effects on stability and digestive characteristics.

  2025cites this paper
• Ultrasonic and thermal effect on the preparation and properties of starch-chlorogenic acid complexes.

  2025cites this paper
• Antioxidant, Antidiabetic, Anti-Obesity, and Anti-Inflammatory Activity of Tomato-Based Functional Snack Bars Enriched with Pea and RuBisCO Proteins

  2025cites this paper
• Efficient Recovery of Phenolic Compounds from Pomegranate (Punica granatum L.) Peel Using Mechanochemical-Assisted Extraction for In Vitro Biological Activities

  2025cites this paper
• Current extraction techniques, biological activities, bioavailability, and patents of rambutan (Nephelium lappaceum L.) peel polyphenols: An updated review

  2025cites this paper
• Evaluating the in vitro anti-diabetic activity of Bryonia dioica root extracts supported by molecular docking analysis

  2025cites this paper
• Application of Subcritical Water Extraction and Enzymatic Hydrolysis as a Combination Green Extraction Technique for Rambutan (Nephelium lappaceum L.) Peel Polyphenol

  2025cites this paper
• Qingke (Highland Barley) from Qinghai-Tibet Plateau: nutritional composition, phenolics profiles, antioxidant activity and hypoglycemic activity

  2025cites this paper
• Aging alleviates the negative impact of citrus peel polysaccharides on the inhibitory effect of EGCG against α-Amylase

  2025cites this paper
• Co-gelatinization with rutin nanoparticles for regulating rice starch digestibility

  2025cites this paper
• Invitro Investigation for Valorization of Kigelia africana (Lam.) Benth. Fruit Fibre Extraction Hydrolysate as a Potential Bioactive Finishing Agent for Diabetic Foot Ulcer Wound Dressing

  2025cites this paper
• Sustainable valorization of citrus by-products: natural deep eutectic solvents for bioactive extraction and biological applications of Citrus sinensis peel

  2025cites this paper
• Reinventing Southern Thai dessert ‘Khanom-La’ via starch-phenolic complex-induced resistant starch: Physicochemical transitions and functional enhancement

  2025cites this paper
• Influence of Onion Peel Extract on the Dough Characteristics of High-Gluten Wheat Flour and the Quality of Bread

  2025cites this paper
• Modulating the multiscale structure and digestibility of OSA starch by phenolic acid substituents and heating process.

  2025cites this paper
• Inhibition mechanism of α-amylase and amyloglucosidase by spherical nanocrystalline cellulose with varying particle sizes.

  2025cites this paper
• Maturity-dependent enzyme inhibition in grape seeds: Urease, α-amylase, and lipase inhibitory activities with lipase docking insights and antimicrobial properties.

  2025cites this paper
• Mechanistic study of phenolic acid inhibition of α-amylase: combining enzyme assays, spectroscopy, and molecular docking

  2025cites this paper
• Mechanism of the synergistic enhancement of digestive resistance in steamed cold noodles by V-type starch-tea polyphenols interactions

  2025cites this paper
• Ligand-enzyme thermodynamic bindings provide an efficient and microscale evaluating approach for α-amylase inhibition of polyphenols.

  2025cites this paper
• In vitro assessment of antidiabetic, anti-obesogenic, and antioxidant potential of pulp and seed extracts from Eugenia involucrata fruits.

  2025cites this paper
• Exploring the effect of L-theanine synergised with EGCG on starch digestibility in ultrasonic field from different perspectives.

  2025cites this paper
• A Review on Healthier Bread Making: Focusing on the Underlying Mechanisms for Decreasing Glycemic Index

  2025influential citation
• Investigation of Crinum solapurense leaves extract for antidiabetic activity and histopathological evaluation in an in-vivo experimental model

  2025cites this paper
• Green coffee and green tea as alternative medicines for the treatment of hyperglycemia

  2024cites this paper
• Inhibition mechanism of α-glucosidase by three geranylated compounds: Kinetic, spectroscopic and molecular docking

  2024cites this paper
• Advances in the treatment of type 2 diabetes mellitus by natural plant polysaccharides through regulation of gut microbiota and metabolism: A review.

  2024cites this paper
• Strategic exploration of whole grain cereals in modulating the glycaemic response

  2024cites this paper
• Comprehensive Identification of Costus pictus Rhizome Extract as a Potent Plant Food: Unveiling Anti-Diabetic, Antimicrobial, Anticancer, and Anti-Inflammatory Properties

  2024cites this paper
• Unveiling the Anti-Diabetic Potential: A Comparative Study on the Vitamin and Amino Acid Profiles of Bioactive Compounds in Fermented and Raw Tamarind (Tamarindus indica L) Seeds

  2024cites this paper
• Turning Wastes into Resources: Red Grape Pomace-Enriched Biscuits with Potential Health-Promoting Properties

  2024cites this paper
• Insights into one drug, multi-target aspects of polyphenols for diabetes management: in vitro, in vivo, and clinical evidence

  2024cites this paper
• Comparative Analysis of Sustainable Extraction Methods and Green Solvents for Olive Leaf Extracts with Antioxidant and Antihyperglycemic Activities

  2024cites this paper
• A review of endogenous non-starch components in cereal matrix: spatial distribution and mechanisms for inhibiting starch digestion

  2024cites this paper
• Antioxidant, α-amylase, and α-glucosidase inhibitory activities of onion (Allium cepa) and shallot (Allium oscalonicum L.) in food ingredients

  2024cites this paper
• Sustainable management of rosemary wastewater and essential oil in agri-environmental bioprocessing

  2024cites this paper
• Hypoglycemic Effects of Extracts Obtained from Endemic Betonica bulgarica Degen and Neič

  2024cites this paper
• Formation and Application of Starch–Polyphenol Complexes: Influencing Factors and Rapid Screening Based on Chemometrics

  2024cites this paper
• White mulberry leaf (Morus alba L.) infusion as a strategy to reduce starch digestibility: The influence of particle size of leaf powder

  2024cites this paper
• Dietary effects of Sclerocarya birrea caffra seed cake replacing soyabean meal on physiology, meat and bone quality of indigenous chickens

  2024cites this paper
• Enhancing physicochemical, rheological properties, and in vitro rumen fermentation of starch with Melastoma candidum D. Don fruit extract.

  2024cites this paper
• Functional Model Beverages of Saffron Floral By-Products: Polyphenolic Composition, Inhibition of Digestive Enzymes, and Rheological Characterization

  2024cites this paper
• Milk casein hydrolysate peptides regulate starch digestion through inhibition of α-glucosidase: An insight into the active oligopeptide screening, enzyme inhibition behaviors, and oligopeptide-enzyme binding interactions

  2024cites this paper
• New insights into the reduction of protein degradation in freshwater fish by proanthocyanidins: Inhibition mechanism and the conformational changes of endogenous cathepsin B.

  2024cites this paper
• Orange passion fruit (Passiflora caerulea L.) as a new raw material for acetic fermentation: evaluation of organic acids and phenolic profile, in vitro digestion, and biological activities.

  2024cites this paper
• Antioxidant, Enzyme Inhibitory, and Protective Effect of Amelanchier lamarckii Extract

  2024cites this paper
• Advances in microbial exopolysaccharides as α-amylase inhibitors: Effects, structure-activity relationships, and anti-diabetic effects in vivo.

  2024cites this paper
• Assessment of polyphenols in purple and red rice bran: Phenolic profiles, antioxidant activities, and mechanism of inhibition against amylolytic enzymes

  2024cites this paper
• Molecular interactions between polyphenols and porcine α-amylase: An inhibition study on starch granules probed by kinetic, spectroscopic, calorimetric and in silico techniques

  2024cites this paper
• Enzymolysis Modes Trigger Diversity in Inhibitor‐α‐Amylase Aggregating Behaviors and Activity Inhibition: A New Insight Into Enzyme Inhibition

  2024cites this paper
• Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review

  2024cites this paper
• Enrichment of polyphenols from Cinnamomum camphora seed kernel by macroporous adsorption resins and evaluation of its antioxidant and enzyme inhibitory activities

  2024cites this paper
• Integrated deep eutectic solvent extraction and resin adsorption for recovering polyphenols from citrus reticulata Blanco peels: Process optimization, compositional analysis, and activity determination

  2024cites this paper
• Investigation of synergistic effect and mechanism of green tea extract and coffee extract on α‐amylase and α‐glucosidase inhibition

  2024cites this paper
• Probiotics intervention for type 2 diabetes mellitus therapy: a review from proposed mechanisms to future prospects

  2024cites this paper
• Antidiabetic, antioxidant, and phytochemical profile of Pennisetum glaucum cultivated in central-southern Morocco and imported from India

  2024cites this paper
• The Influence of Different Polyphenols on the Digestibility of Various Kinds of Starch and the Value of the Estimated Glycemic Index

  2024cites this paper
• Effect of tea polyphenols supplement on growth performance, antioxidation, and gut microbiota in squabs

  2024cites this paper
• Onion (Allium cepa L.) Skin Waste Valorization: Unveiling the Phenolic Profile and Biological Potential for the Creation of Bioactive Agents through Subcritical Water Extraction

  2024cites this paper
• Quercetin slow-release system delays starch digestion via inhibiting transporters and enzymes.

  2024cites this paper
• Health-Promoting Potential of Mandarin Pomace Extracts Enriched with Phenolic Compounds

  2024cites this paper
• Alpha-glucosidase and α-amylase inhibitory activity of Pistacia atlantica Desf. gall extracts and identification of putative bioactives using a combined UPLC fingerprinting and molecular docking approach

  2024cites this paper
• Moringa oleifera flowers: insights into their aroma chemistry, anti-inflammatory, antioxidant, and enzyme inhibitory properties

  2024cites this paper
• Monitoring Enzymatic Reaction Kinetics and Activity Assays in Confined Nanospace.

  2024cites this paper
• Challenges and opportunities in developing low glycemic index foods with white kidney bean α-amylase inhibitor

  2024cites this paper
• Exploration of phenolic profile from mangosteen (Garcinia mangostana L.) pericarp and their contribution to inhibitory effects on α-amylase and α-glucosidase

  2024cites this paper
• Assessment of the germination power and α-amylase activity in the soil rhizospheric compartment amended with olive mill waste waters

  2024cites this paper
• Purification and Characterization of Proteinaceous Thermostable α-Amylase Inhibitor from Sardinian Common Bean Nieddone Cultivar (Phaseolus vulgaris L.)

  2024cites this paper
• The impact of sour cherry juice (Prunus cerasus) on reducing glucose release during in vitro starch digestion

  2024cites this paper
• Proteins Make Tea Polyphenol EGCG Not Always Develop Satisfactory α-Glucosidase Inhibition: The Influences of Three Proteins on α-Glucosidase Inhibitory Activity of EGCG

  2024cites this paper