MAP4K4 associates with BIK1 to regulate plant innate immunity

To perceive pathogens, plants employ pattern recognition receptor (PRR) complexes, which then transmit these signals via the receptor‐like cytoplasmic kinase BIK1 to induce defense responses. How BIK1 activity and stability are controlled is still not completely understood. Here, we show that the Hippo/STE20 homolog MAP4K4 regulates BIK1‐mediated immune responses. MAP4K4 associates and phosphorylates BIK1 at Ser233, Ser236, and Thr242 to ensure BIK1 stability and activity. Furthermore, MAP4K4 phosphorylates PP2C38 at Ser77 to enable flg22‐induced BIK1 activation. Our results uncover that a Hippo/STE20 homolog, MAP4K4, maintains the homeostasis of the central immune component BIK1.

• Publication year

  2019

• Venue

  EMBO Reports

• Publication date

  2019-09-02

• Fields of study

  Biology, Medicine, Engineering, Environmental Science

• Identifiers
  DOI 10.15252/embr.201947965PMID 31475431PMCID PMC6832008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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