The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Cell Biology

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncb1822PMID 19151708
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MDA-MB-435 cells are from melanoma, not from breast cancer

  2009cited by this paper
• AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

  2008cited by this paper
• ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitor

  2008cited by this paper
• Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1

  2007cited by this paper
• The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

  2007cited by this paper
• PIN1, the cell cycle and cancer

  2007cited by this paper
• Notch emerges as new cancer drug target.

  2007cited by this paper
• The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

  2007cited by this paper
• The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

  2007cited by this paper
• Tumorigenesis and Neoplastic Progression Notch2 Signaling Induces Apoptosis and Inhibits Human MDA-MB-231 Xenograft Growth

  2007cited by this paper
• MDA-MB-435 cells are derived from M14 Melanoma cells––a loss for breast cancer, but a boon for melanoma research

  2007cited by this paper
• Aberrant Activation of Notch Signaling in Human Breast Cancer

  2006cited by this paper
• Notch signaling in cancer.

  2006cited by this paper
• The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

  2006cited by this paper
• Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

  2006cited by this paper
• The gamma-secretase complex: membrane-embedded proteolytic ensemble.

  2006cited by this paper
• Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.

  2006cited by this paper
• The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble

  2006cited by this paper
• Notch signalling: a simple pathway becomes complex

  2006cited by this paper
• The roles of receptor and ligand endocytosis in regulating Notch signaling

  2005cited by this paper
• Pin1 promotes production of Alzheimer's amyloid beta from beta-cleaved amyloid precursor protein.

  2005cited by this paper
• The Notch pathway in ovarian carcinomas and adenomas

  2005cited by this paper
• Pin1 links the activities of c-Abl and p300 in regulating p73 function.

  2004cited by this paper
• p53 regulates thymic Notch1 activation

  2004cited by this paper
• Notch signaling: a different sort makes the cut.

  2004cited by this paper
• Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

  2004cited by this paper
• Prevalent overexpression of prolyl isomerase Pin1 in human cancers.

  2004cited by this paper
• Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

  2004cited by this paper
• Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium.

  2004cited by this paper
• Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

  2004cited by this paper
• Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation.

  2003cited by this paper
• The role of Notch in tumorigenesis: oncogene or tumour suppressor?

  2003cited by this paper
• A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

  2003cited by this paper
• Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

  2003cited by this paper
• The prolyl isomerase Pin1 in breast development and cancer

  2003cited by this paper
• Activated Notch1 associates with a presenilin‐1/γ‐secretase docking site

  2003cited by this paper
• Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.

  2003cited by this paper
• Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

  2002cited by this paper
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

  2002cited by this paper
• Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling

  2002cited by this paper
• Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

  2002cited by this paper
• Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC.

  2001cited by this paper
• Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC

  2001cited by this paper
• Phosphorylation of Ser2078 Modulates the Notch2 Function in 32D Cell Differentiation*

  2001cited by this paper
• Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins.

  2000cited by this paper
• Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

  2000cited by this paper
• Notchic-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation

  2000cited by this paper
• Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes.

  2000cited by this paper
• Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium.

  2000cited by this paper
• Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

  2000cited by this paper
• A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

  1999cited by this paper
• Function of WW domains as phosphoserine- or phosphothreonine-binding modules.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Tissue microarrays for high-throughput molecular profiling of tumor specimens

  1998cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998cited by this paper
• Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription*

  1997cited by this paper
• Signalling downstream of activated mammalian Notch

  1995cited by this paper
• UKCCCR Guidelines for the welfare of animals in experimental neoplasia

  1989cited by this paper
• UKCCCR guidelines for the welfare of animals in experimental neoplasia.

  1989cited by this paper

• Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer.

  2026cites this paper
• Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery

  2024cites this paper
• Pin1 Downregulation Is Involved in Excess Retinoic Acid-Induced Failure of Neural Tube Closure

  2024cites this paper
• Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation

  2024cites this paper
• Unraveling the Dual Role of ADAM10: Bridging the Gap between Cancer and Alzheimer's Disease.

  2024cites this paper
• The role of the master cancer regulator Pin1 in the development and treatment of cancer

  2024cites this paper
• The mechanisms of Pin1 as targets for cancer therapy

  2024cites this paper
• NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells

  2024cites this paper
• Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma

  2023cites this paper
• Molecular pathways and therapeutic targets linked to triple-negative breast cancer (TNBC)

  2023cites this paper
• Molecular biological mechanism of action in cancer therapies: Juglone and its derivatives, the future of development.

  2022cites this paper
• Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics

  2022cites this paper
• Reduced chromatin accessibility correlates with resistance to Notch activation

  2022cites this paper
• Resveratrol attenuates atherosclerotic endothelial injury through the Pin1/Notch1 pathway.

  2022cites this paper
• Targeting peptidyl-prolyl isomerase 1 in experimental pulmonary arterial hypertension

  2022cites this paper
• The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy

  2022cites this paper
• Correlation between Pin1 and Bladder Cancer

  2022cites this paper
• Expression, Purification, Structural and Functional Characterization of Recombinant Human Parvulin 17

  2022cites this paper
• Targeting Notch to Maximize Chemotherapeutic Benefits: Rationale, Advanced Strategies, and Future Perspectives

  2021cites this paper
• The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

  2021cites this paper
• Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

  2021cites this paper
• Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2.

  2021cites this paper
• Roles of peptidyl-prolyl isomerase Pin1 in disease pathogenesis

  2021cites this paper
• Notch Signaling and the Breast Cancer Microenvironment.

  2021cites this paper
• Notch Signaling in Embryology and Cancer: Notch Signaling in Cancer

  2021cites this paper
• Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

  2020cites this paper
• Notch1 switches progenitor competence in inducing medulloblastoma

  2020cites this paper
• Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways

  2020cites this paper
• PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals

  2020cites this paper
• Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells.

  2020cites this paper
• Pro-metastatic functions of Notch signaling is mediated by CYR61 in breast cells.

  2020cites this paper
• A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer

  2020cites this paper
• FASN Negatively Regulates NF-kB/P65 Expression in Breast Cancer Cells by Disrupting Its Stability

  2020cites this paper
• Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

  2020cites this paper
• Pinning Down the Transcription: A Role for Peptidyl-Prolyl cis-trans Isomerase Pin1 in Gene Expression

  2020cites this paper
• The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers

  2020cites this paper
• Deficiency of microRNA-628-5p promotes the progression of gastric cancer by upregulating PIN1

  2020cites this paper
• Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance

  2020cites this paper
• Development of a Notch pathway assay and quantification of functional Notch pathway activity in T-cell acute lymphoblastic leukemia

  2020cites this paper
• The Proteomic Analysis of Exosomes from Breast Cell Lines Reveals Potential Biomarkers of Breast Cancer

  2020cites this paper
• Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression

  2019cites this paper
• Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis

  2019cites this paper
• Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors

  2019cites this paper
• Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 as a molecular target in breast cancer: a therapeutic perspective of gynecological cancer

  2019cites this paper
• A Guide to PIN1 Function and Mutations Across Cancers

  2019cites this paper
• Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype

  2019cites this paper
• MicroRNA Biogenesis is Enhanced by Liposome-Encapsulated Pin1 Inhibitor in Hepatocellular Carcinoma

  2019cites this paper
• Oncogenic Hijacking of the PIN1 Signaling Network

  2019cites this paper
• Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

  2019cites this paper
• Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

  2018cites this paper
• Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

  2018cites this paper
• Pin1 impairs microRNA biogenesis by mediating conformation change of XPO5 in hepatocellular carcinoma

  2018cites this paper
• Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1

  2018influential citation
• Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis.

  2018cites this paper
• Structure and function of the human parvulins Pin1 and Par14/17

  2018cites this paper
• The Notch3 Receptor and Its Intracellular Signaling-Dependent Oncogenic Mechanisms.

  2018cites this paper
• Pin1 Modulation in Physiological Status and Neurodegeneration. Any Contribution to the Pathogenesis of Type 3 Diabetes?

  2018cites this paper
• PIN1 isomerisation of BRCA1 promotes replication fork protection

  2018cites this paper
• NOTCH1 modulates activity of DNA-PKcs.

  2018cites this paper
• Cytoplasmic Pin1 expression is correlated with poor prognosis in colorectal cancer.

  2018cites this paper
• PIN1 in Cell Cycle Control and Cancer

  2018cites this paper
• Cytoplasmic Pin1 expression is increased in human cutaneous melanoma and predicts poor prognosis

  2018cites this paper
• Exploring the Regulatory Mechanism of the Notch Ligand Receptor Jagged1 Via the Aryl Hydrocarbon Receptor in Breast Cancer

  2018cites this paper
• Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1.

  2018cites this paper
• Peptidyl-prolyl isomerase (PPIase): an emerging area in tumor biology

  2017cites this paper
• Mechanistic Insight Into PIN1 Regulation On MYC: A New Interaction Pattern & The Association With The Nuclear Pore

  2017cites this paper
• Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways

  2017cites this paper
• YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

  2017cites this paper
• The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module

  2017cites this paper
• Dynamic regulation of Pin1 expression and function during zebrafish development

  2017cites this paper
• A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

  2017cites this paper
• Notch Shapes the Innate Immunophenotype in Breast Cancer.

  2017cites this paper
• Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway.

  2017cites this paper
• The Pin1 orthologue Dodo regulates heterochromatin formation and activity of transposable elements in Drosophila germline and neural tissue

  2017cites this paper
• Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis1

  2017cites this paper
• The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

  2016cites this paper
• Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

  2016cites this paper
• NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

  2016cites this paper
• Understanding the role of PIN1 in hepatocellular carcinoma

  2016cites this paper
• PIN1 in breast development and cancer: a clinical perspective

  2016influential citation
• Title Understanding the role of PIN 1 in hepatocellular carcinoma

  2016cites this paper
• ROLE OF IRF 6 IN NOTCH REGULATED APOPTOSIS , CELL CYCLE AND DIFFERENTIATION IN BREAST EPITHELIAL CELLS

  2016cites this paper
• Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells

  2016cites this paper
• Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression

  2016cites this paper
• The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways.

  2016cites this paper
• Neighboring phosphoSer‐Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding

  2016cites this paper
• Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

  2016cites this paper
• The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

  2016cites this paper
• A Presenilin-2–ARF4 trafficking axis modulates Notch signaling during epidermal differentiation

  2016cites this paper
• Notch Signaling in Neuroendocrine Tumors

  2016cites this paper
• Gr upSM Pharmacological Inhibition of Pin 1 for Cancer Therapy

  2016influential citation
• Targeting Peptidyl-Prolyl Isomerase Pin1 to Inhibit Tumor Cell Aggressiveness

  2016cites this paper
• Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

  2016cites this paper
• Targeting Notch as a Therapeutic Approach for Human Malignancies.

  2016cites this paper
• 肽基脯氨酰顺反异构酶 Pin1 在阿尔茨海默病 发生发展中的作用 王敬章

  2015cites this paper
• Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain

  2015influential citation
• Investigation of PIN1 as a Genetic Modifier in Li-Fraumeni Syndrome

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Landscape of Pin1 in the cell cycle

  2015cites this paper