Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2006-03-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.0600065103PMID 16501043PMCID PMC1450156
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

  2005cited by this paper
• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

  2005cited by this paper
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  2005cited by this paper
• High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.

  2005cited by this paper
• Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.

  2004cited by this paper
• Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

  2004cited by this paper
• Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

  2004cited by this paper
• Wnt Signaling and Breast Cancer

  2004cited by this paper
• The Non-transmembrane Form of Delta1, but Not of Jagged1, Induces Normal Migratory Behavior Accompanied by Fibroblast Growth Factor Receptor 1-dependent Transformation*

  2004cited by this paper
• A divergent canonical WNT-signaling pathway regulates microtubule dynamics

  2004cited by this paper
• The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

  2004cited by this paper
• Comparative biology of mouse versus human cells: modelling human cancer in mice

  2003cited by this paper
• Pathology and Genetics of Tumours of the Breast and Female Genital Organs

  2003cited by this paper
• ATM and related protein kinases: safeguarding genome integrity

  2003cited by this paper
• TP53 and breast cancer

  2003cited by this paper
• Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

  2003cited by this paper
• Amplification, up‐regulation and over‐expression of DVL‐1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers

  2003cited by this paper
• Molecular biology and genetics of breast cancer development: a clinical perspective.

  2002cited by this paper
• Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway

  2002cited by this paper
• Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

  2002cited by this paper
• Wnt-3A/β-Catenin Signaling Induces Transcription from the LEF-1 Promoter* 210

  2002cited by this paper
• Contributions of mouse biology to breast cancer research.

  2002cited by this paper
• WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type

  2001cited by this paper
• Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

  2001cited by this paper
• Real-time quantitative telomeric repeat amplification protocol assay for the detection of telomerase activity.

  2001cited by this paper
• Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

  2001cited by this paper
• Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation.

  2001cited by this paper
• β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

  2001cited by this paper
• Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/β-catenin signaling is activated in human colon tumors

  2001cited by this paper
• The Hallmarks of Cancer Review

  2000cited by this paper
• Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

  2000cited by this paper
• Wnt signaling and cancer.

  2000cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Creation of human tumour cells with defined genetic elements

  1999cited by this paper
• Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes

  1999cited by this paper
• p53 mutation as a genetic trait of typical medullary breast carcinoma.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis*

  1999cited by this paper
• Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.

  1998cited by this paper
• Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney.

  1998cited by this paper
• Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

  1998cited by this paper
• Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

  1998cited by this paper
• DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*

  1998cited by this paper
• Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2

  1997cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• Conservation of the Notch signalling pathway in mammalian neurogenesis.

  1997cited by this paper
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.

  1997cited by this paper
• Transformation by Wnt family proteins correlates with regulation of beta-catenin.

  1997cited by this paper
• Functional interaction of β-catenin with the transcription factor LEF-1

  1996cited by this paper
• Functional interaction of beta-catenin with the transcription factor LEF-1.

  1996cited by this paper
• Induction of kidney epithelial morphogenesis by cells expressing Wnt-1.

  1994cited by this paper
• Versatile retroviral vectors for potential use in gene therapy.

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.

  1992cited by this paper
• Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.

  1988cited by this paper
• Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors

  1987cited by this paper
• Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

  1985cited by this paper
• Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

  1982cited by this paper

• Role of KCTD12 in Ovarian Tumor Progression and Chemo Resistance Via Regulation of WNT and NOTCH Pathways

  2026cites this paper
• Harnessing the connection of the Wnt/beta-catenin pathway and other signaling pathways in glioblastoma multiforme.

  2026cites this paper
• Targeting DLL3: Innovative Strategies for Tumor Treatment

  2025cites this paper
• Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

  2025cites this paper
• Breast Morphogenesis: From Normal Development to Cancer.

  2025cites this paper
• Natural bioactive compounds as notch signaling modulators: cutting-edge strategies for cancer therapy

  2025cites this paper
• Understanding Susceptibility to Breast Cancer: From Risk Factors to Prevention Strategies

  2025cites this paper
• High glucose promotes cisplatin chemoresistance in MDA-MB-231 breast cancer derived cells through changes in gene expression and multiple signaling pathways

  2025cites this paper
• Transcriptional Regulation of Lipid Metabolism by Wnt Signaling and Hox Protein Cues.

  2025cites this paper
• Inhibition of DDX3 modulates immune signaling in aggressive breast cancers.

  2025cites this paper
• On the mechanisms of epidermal stemness and differentiation

  2025cites this paper
• Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer

  2024cites this paper
• FOXO1 promotes the expression of canonical WNT target genes in examined basal‐like breast and glioblastoma multiforme cancer cells

  2023cites this paper
• Anaplastic Large Cell Lymphomas With The 6p25.3 Rearrangement Are A Heterogeneous Group Of Tumours With A Diverse Molecular Background.

  2023cites this paper
• Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy

  2023cites this paper
• LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells

  2023cites this paper
• Identification of DLL3-related genes affecting the prognosis of patients with colon adenocarcinoma

  2023cites this paper
• Implications of Axis Inhibition Protein 2 in Breast Cancer Progression

  2023cites this paper
• Targeted therapies against breast cancer: Clinical perspectives, obstacles and new opportunities

  2023cites this paper
• Advances in new targets for immunotherapy of small cell lung cancer

  2023cites this paper
• The role of epigenetic modifications in drug resistance and treatment of breast cancer

  2022cites this paper
• Research progress on RNA-binding proteins in breast cancer

  2022cites this paper
• A genome-wide cell-free DNA methylation analysis identifies an episignature associated with metastatic luminal B breast cancer

  2022cites this paper
• Herbal Ingredients in the Prevention of Breast Cancer: Comprehensive Review of Potential Molecular Targets and Role of Natural Products

  2022cites this paper
• Wnt Signaling in the Breast: From Development to Disease

  2022cites this paper
• Hyperactive WNT/CTNNB1 signaling induces a competing cell proliferation and epidermal differentiation response in the mouse mammary epithelium

  2021cites this paper
• Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/β-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment.

  2021cites this paper
• The Relevance of Notch Signaling in Cancer Progression.

  2021cites this paper
• Notch in Head and Neck Cancer.

  2021cites this paper
• Notch Signalling in Breast Development and Cancer

  2021cites this paper
• Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: A brief overview

  2021cites this paper
• Progesterone Receptor Signaling in the Breast Tumor Microenvironment.

  2021cites this paper
• Elevated DLL3 in stomach cancer by tumor-associated macrophages enhances cancer-cell proliferation and cytokine secretion of macrophages

  2021cites this paper
• Notch Signaling in Embryology and Cancer: Notch Signaling in Cancer

  2021cites this paper
• Mammary Development and Breast Cancer: a Notch Perspective

  2021cites this paper
• Notch in Human Cancers—A Complex Tale

  2021cites this paper
• Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues—A Comprehensive Review With Analysis

  2020cites this paper
• Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

  2020cites this paper
• Novel strategies to target chemoresistant triple-negative breast cancer

  2020cites this paper
• Inhibition of the Wnt Signalling Pathway: An Avenue to Control Breast Cancer Aggressiveness

  2020cites this paper
• Targeting Notch Trafficking and Processing in Cancers

  2020cites this paper
• Shaping of the Tumor Microenvironment by Notch Signaling.

  2020cites this paper
• Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence

  2020cites this paper
• PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination

  2020cites this paper
• Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells

  2020cites this paper
• Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review

  2020cites this paper
• Heat Killed Salmonella typhimurium Protects Intestine Against Radiation Injury Through Wnt Signaling Pathway

  2020cites this paper
• DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile.

  2019cites this paper
• Targeting the crosstalks of Wnt pathway with Hedgehog and Notch for cancer therapy

  2019cites this paper
• Convergence of Wnt and Notch signaling controls ovarian cancer cell survival

  2019cites this paper
• In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties.

  2019cites this paper
• DLL3 is regulated by LIN28B and miR-518d-5p and regulates cell proliferation, migration and chemotherapy response in advanced small cell lung cancer.

  2019cites this paper
• Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin

  2019cites this paper
• The Wnt Signaling Landscape of Mammary Stem Cells and Breast Tumors.

  2018cites this paper
• Dishevelled: A masterful conductor of complex Wnt signals.

  2018cites this paper
• Review on the molecular signaling pathways involved in controlling cancer stem cells and treatment

  2018cites this paper
• The Homeotic Protein SIX3 Suppresses Carcinogenesis and Metastasis through Recruiting the LSD1/NuRD(MTA3) Complex

  2018cites this paper
• Moving Breast Cancer Therapy up a Notch

  2018cites this paper
• Notch Signaling in the Tumor Microenvironment.

  2018cites this paper
• Bioinformatics functional analysis of let-7a, miR-34a, and miR-199a/b reveals novel insights into immune system pathways and cancer hallmarks for hepatocellular carcinoma

  2018cites this paper
• The Notch Pathway in Breast Cancer Progression

  2018cites this paper
• High-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas

  2018cites this paper
• Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer

  2018cites this paper
• Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

  2018cites this paper
• Targeting Stemness: Implications for Precision Medicine in Breast Cancer.

  2017cites this paper
• The Two Faces of Notch in Solid Cancers

  2017cites this paper
• Le phénotype mésenchymateux et la réponse aux agents anti-VEGF dans le cancer colorectal

  2017cites this paper
• Cancer stem cells and homologous recombination deficiency in serous ovarian and endometrial carcinoma

  2017cites this paper
• Correction: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

  2017cites this paper
• Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

  2017cites this paper
• Potential therapeutic targets of Guggulsterone in cancer

  2017cites this paper
• The role of Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets

  2017cites this paper
• Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity

  2017cites this paper
• Notch Signaling

  2017cites this paper
• The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas

  2017cites this paper
• Endocrine Therapy of Estrogen Receptor-Positive Breast Cancer Cells: Early Differential Effects on Stem Cell Markers

  2017cites this paper
• The role of Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets.

  2017cites this paper
• Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance

  2016cites this paper
• Downregulation of Notch Signaling Pathway as an Effective Chemosensitizer for Cancer Treatment

  2016cites this paper
• Novel Cancer Therapies by Molecular Targeting Distinct Growth Factor Pathways and Drug Resistance-Associated Molecules in Cancer- and Metastasis-Initiating Cells

  2016cites this paper
• Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells

  2016cites this paper
• Discovery and characterization of miRNAs in mouse thymus responses to ionizing radiation by deep sequencing

  2016cites this paper
• Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

  2016cites this paper
• Notch signaling in prostate cancer: refining a therapeutic opportunity.

  2016cites this paper
• TARGETING NOTCH TRAFFICKING IN HUMAN CANCER CELLS: A.PHARMACOLOGIC INHIBITION OF THE VACUOLAR H+ ATPASE REDUCES PHYSIOLOGIC AND ONCOGENIC NOTCH SIGNALING. B.HIGH CONTENT SCREEN FOR NOVEL MODULATORS OF THE NOTCH PATHWAY.

  2016cites this paper
• Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer

  2016cites this paper
• Chronic lymphocytic leukemia: Time to go past genomics?

  2016influential citation
• Targeting Notch as a Therapeutic Approach for Human Malignancies.

  2016cites this paper
• Mathematical modeling of bone marrow - peripheral blood dynamics in the disease state based on current emerging paradigms, part II.

  2016cites this paper
• Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway

  2016cites this paper
• Mathematical modeling of bone marrow--peripheral blood dynamics in the disease state based on current emerging paradigms, part I.

  2016cites this paper
• Cancer Stem Cells — Perspectives and How to Target Them

  2016cites this paper
• KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties

  2016cites this paper
• Hypodontia, a prospective predictive marker for tumor?

  2016cites this paper
• Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis

  2016cites this paper
• ROLE OF IRF 6 IN NOTCH REGULATED APOPTOSIS , CELL CYCLE AND DIFFERENTIATION IN BREAST EPITHELIAL CELLS

  2016cites this paper
• Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells.

  2016cites this paper
• Regulation of Monocarboxylic Acid Transporter 1 Trafficking by the Canonical Wnt/β-Catenin Pathway in Rat Brain Endothelial Cells Requires Cross-talk with Notch Signaling*

  2016cites this paper
• The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies

  2015cites this paper
• Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer

  2015cites this paper