The molecular biology of esophageal and gastric cancer and their precursors: oncogenes, tumor suppressor genes, and growth factors.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Human Pathology

• Publication date

  1994-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0046-8177(94)90056-6PMID 7927320
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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• Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.

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• [Role of the expression of c-Met receptor in the progression of gastric cancer].

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  2005cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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  2001cites this paper
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  2000cites this paper
• [Morphological and molecular bases of digestive tract carcinogenesis].

  2000cites this paper
• Genetische Heterogenität in Adenokarzinomen des Ösophagus (Barrettkarzinom)

  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1999cites this paper
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  1998cites this paper
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  1998cites this paper
• Interphase cytogenetics of esophageal adenocarcinoma and precursor lesions.

  1998cites this paper
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  1998cites this paper