Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?

Type 2 diabetes mellitus (T2D), which is often accompanied by hyperinsulinemia and insulin resistance, is associated with an increased risk for developing mild cognitive impairment and Alzheimer’s disease (AD); however, the underlying mechanisms for this association are still unclear. Recent findings have shown that hyperinsulinemia and insulin resistance can coexist or be independent events. This makes it imperative to determine the contribution of these individual conditions in impacting AD. This literature review highlights the recent developments of hyperinsulinemia and insulin resistance involvement in the progression and pathogenesis of AD.

• Publication year

  2019

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2019-11-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.3233/JAD-190808PMID 31744006
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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