Intranasal insulin in Alzheimer’s disease: Food for thought

Accumulating evidence suggests that disrupted brain insulin signaling promotes the development and progression of Alzheimer’s disease (AD), driving clinicians to target this circuitry. While both traditional and more modern antidiabetics show promise in combating insulin resistance, intranasal insulin appears to be the most efficient method of boosting brain insulin. Furthermore, intranasal delivery elegantly avoids adverse effects from peripheral insulin administration. However, there remain significant open questions regarding intranasal insulin’s efficacy, safety, and potential as an adjunct or mono-therapy. Thus, this review aims to critically evaluate the present evidence and future potential of intranasal insulin as a meaningful treatment for AD. This article is part of the Special Issue entitled ‘Metabolic Impairment as Risk Factors for Neurodegenerative Disorders.’

• Publication year

  2017

• Venue

  Neuropharmacology

• Publication date

  2017-11-24

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.neuropharm.2017.11.037PMID 29180222PMCID 10523803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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